FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156011244> ?p ?o ?g. }

• W2156011244 endingPage "2891" @default.
• W2156011244 startingPage "2880" @default.
• W2156011244 abstract "Neurexins are cell adhesion molecules that help to specify and stabilize synapses and provide receptors for neuroligins, neurexophilins, dystroglycans and alpha-latrotoxins. We previously reported significant allele frequency differences for single nucleotide polymorphisms (SNPs) in the neurexin 3 (NRXN3) gene in each of two comparisons between individuals who were dependent on illegal substances and controls. We now report work clarifying details of NRXN3's gene structure and variants and documenting association of NRXN3 SNPs with alcohol dependence. We localize this association signal with the vicinity of the NRXN3 splicing site 5 (SS#5). A splicing site SNP, rs8019381, that is located 23 bp from the SS#5 exon 23 donor site displays association with P = 0.0007 (odds ratio = 2.46). Including or excluding exon 23 at SS#5 produces soluble or transmembrane NRXN3 isoforms. We thus examined expression of these NRXN3 isoforms in postmortem human cerebral cortical brain samples from individuals with varying rs8019381 genotypes. Two of the splice variants that encode transmembrane NRXN3 isoforms were expressed at significantly lower levels in individuals with the addiction-associated rs8019381 'T' allele than in CC homozygotes. Taken together with recent reports of NRXN3 association with nicotine dependence and linkage with opiate dependence, these data support roles for NRXN3 haplotypes that alter expression of specific NRXN3 isoforms in genetic vulnerabilities to dependence on a variety of addictive substances." @default.
• W2156011244 created "2016-06-24" @default.
• W2156011244 creator A5010407734 @default.
• W2156011244 creator A5020912488 @default.
• W2156011244 creator A5020929087 @default.
• W2156011244 creator A5022384896 @default.
• W2156011244 creator A5048570234 @default.
• W2156011244 creator A5050634480 @default.
• W2156011244 creator A5061872948 @default.
• W2156011244 creator A5077200969 @default.
• W2156011244 date "2007-09-04" @default.
• W2156011244 modified "2023-10-15" @default.
• W2156011244 title "Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms" @default.
• W2156011244 cites W1513458886 @default.
• W2156011244 cites W1529309506 @default.
• W2156011244 cites W1546762987 @default.
• W2156011244 cites W1611867296 @default.
• W2156011244 cites W1823225248 @default.
• W2156011244 cites W1966727055 @default.
• W2156011244 cites W1973800056 @default.
• W2156011244 cites W1975861627 @default.
• W2156011244 cites W1975898154 @default.
• W2156011244 cites W1976841572 @default.
• W2156011244 cites W1984795378 @default.
• W2156011244 cites W1989706444 @default.
• W2156011244 cites W1990122129 @default.
• W2156011244 cites W1990865404 @default.
• W2156011244 cites W1993415479 @default.
• W2156011244 cites W1994542213 @default.
• W2156011244 cites W1994882032 @default.
• W2156011244 cites W1997494682 @default.
• W2156011244 cites W2000646669 @default.
• W2156011244 cites W2003217331 @default.
• W2156011244 cites W2008179914 @default.
• W2156011244 cites W2008649252 @default.
• W2156011244 cites W2015262258 @default.
• W2156011244 cites W2016067059 @default.
• W2156011244 cites W2021051417 @default.
• W2156011244 cites W2023179463 @default.
• W2156011244 cites W2030159700 @default.
• W2156011244 cites W2030705868 @default.
• W2156011244 cites W2036879415 @default.
• W2156011244 cites W2037773157 @default.
• W2156011244 cites W2046801718 @default.
• W2156011244 cites W2048361100 @default.
• W2156011244 cites W2051468191 @default.
• W2156011244 cites W2051717152 @default.
• W2156011244 cites W2054235364 @default.
• W2156011244 cites W2059367496 @default.
• W2156011244 cites W2063777298 @default.
• W2156011244 cites W2064352628 @default.
• W2156011244 cites W2067561211 @default.
• W2156011244 cites W2070791340 @default.
• W2156011244 cites W2071746055 @default.
• W2156011244 cites W2079513506 @default.
• W2156011244 cites W2080324921 @default.
• W2156011244 cites W2088839435 @default.
• W2156011244 cites W2092558173 @default.
• W2156011244 cites W2092782657 @default.
• W2156011244 cites W2092932076 @default.
• W2156011244 cites W2094522006 @default.
• W2156011244 cites W2099814519 @default.
• W2156011244 cites W2101407138 @default.
• W2156011244 cites W2112271873 @default.
• W2156011244 cites W2115573224 @default.
• W2156011244 cites W2122253235 @default.
• W2156011244 cites W2123491442 @default.
• W2156011244 cites W2130421403 @default.
• W2156011244 cites W2134012226 @default.
• W2156011244 cites W2145070407 @default.
• W2156011244 cites W2151566815 @default.
• W2156011244 cites W2162530578 @default.
• W2156011244 cites W2171804213 @default.
• W2156011244 cites W2171822179 @default.
• W2156011244 cites W2184338168 @default.
• W2156011244 cites W4230194875 @default.
• W2156011244 doi "https://doi.org/10.1093/hmg/ddm247" @default.
• W2156011244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17804423" @default.
• W2156011244 hasPublicationYear "2007" @default.
• W2156011244 type Work @default.
• W2156011244 sameAs 2156011244 @default.
• W2156011244 citedByCount "97" @default.
• W2156011244 countsByYear W21560112442012 @default.
• W2156011244 countsByYear W21560112442013 @default.
• W2156011244 countsByYear W21560112442014 @default.
• W2156011244 countsByYear W21560112442015 @default.
• W2156011244 countsByYear W21560112442016 @default.
• W2156011244 countsByYear W21560112442017 @default.
• W2156011244 countsByYear W21560112442018 @default.
• W2156011244 countsByYear W21560112442019 @default.
• W2156011244 countsByYear W21560112442020 @default.
• W2156011244 countsByYear W21560112442021 @default.
• W2156011244 countsByYear W21560112442022 @default.
• W2156011244 countsByYear W21560112442023 @default.
• W2156011244 crossrefType "journal-article" @default.
• W2156011244 hasAuthorship W2156011244A5010407734 @default.
• W2156011244 hasAuthorship W2156011244A5020912488 @default.
• W2156011244 hasAuthorship W2156011244A5020929087 @default.

• next