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- W2156024903 abstract "Folpet and captan are fungicides whose genotoxicity depends on their chemical reaction with thiols. Multiple mutagenicity tests have been conducted on these compounds due to their positive activity in vitro and their association with gastrointestinal tumors in mice. A review of the collective data shows that these compounds have in vitro mutagenic activity but are not genotoxic in vivo. This dichotomy is primarily due to the rapid degradation of folpet and captan in the presence of thiol-rich matrices typically found in vivo. Genotoxicity has not been found in the duodenum, the mouse tumor target tissue. It is concluded that folpet like captan presents an unlikely risk of genotoxic effects in humans." @default.
- W2156024903 created "2016-06-24" @default.
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- W2156024903 creator A5012174989 @default.
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- W2156024903 date "2010-06-23" @default.
- W2156024903 modified "2023-10-17" @default.
- W2156024903 title "Genetic toxicology of folpet and captan" @default.
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- W2156024903 doi "https://doi.org/10.3109/10408444.2010.481663" @default.
- W2156024903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20569196" @default.
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