Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156027679> ?p ?o ?g. }
- W2156027679 endingPage "2881" @default.
- W2156027679 startingPage "2866" @default.
- W2156027679 abstract "Chromatin assembly factor-1 (CAF-1) is a three-subunit protein complex conserved throughout eukaryotes that deposits histones during DNA synthesis. Here we present a novel role for the human p150 subunit in regulating nucleolar macromolecular interactions. Acute depletion of p150 causes redistribution of multiple nucleolar proteins and reduces nucleolar association with several repetitive element-containing loci. Of note, a point mutation in a SUMO-interacting motif (SIM) within p150 abolishes nucleolar associations, whereas PCNA or HP1 interaction sites within p150 are not required for these interactions. In addition, acute depletion of SUMO-2 or the SUMO E2 ligase Ubc9 reduces α-satellite DNA association with nucleoli. The nucleolar functions of p150 are separable from its interactions with the other subunits of the CAF-1 complex because an N-terminal fragment of p150 (p150N) that cannot interact with other CAF-1 subunits is sufficient for maintaining nucleolar chromosome and protein associations. Therefore these data define novel functions for a separable domain of the p150 protein, regulating protein and DNA interactions at the nucleolus." @default.
- W2156027679 created "2016-06-24" @default.
- W2156027679 creator A5009385854 @default.
- W2156027679 creator A5026127536 @default.
- W2156027679 creator A5044938342 @default.
- W2156027679 creator A5047125691 @default.
- W2156027679 creator A5051501369 @default.
- W2156027679 creator A5065154340 @default.
- W2156027679 creator A5069076773 @default.
- W2156027679 creator A5091035103 @default.
- W2156027679 date "2014-09-15" @default.
- W2156027679 modified "2023-10-14" @default.
- W2156027679 title "A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli" @default.
- W2156027679 cites W14502254 @default.
- W2156027679 cites W1541379084 @default.
- W2156027679 cites W1620334800 @default.
- W2156027679 cites W1964232579 @default.
- W2156027679 cites W1964541915 @default.
- W2156027679 cites W1968574403 @default.
- W2156027679 cites W1968865001 @default.
- W2156027679 cites W1972029155 @default.
- W2156027679 cites W1975859486 @default.
- W2156027679 cites W1976470213 @default.
- W2156027679 cites W1976604740 @default.
- W2156027679 cites W1977508050 @default.
- W2156027679 cites W1977792673 @default.
- W2156027679 cites W1990299806 @default.
- W2156027679 cites W1990917996 @default.
- W2156027679 cites W1992763575 @default.
- W2156027679 cites W1997589266 @default.
- W2156027679 cites W1999236460 @default.
- W2156027679 cites W2001474414 @default.
- W2156027679 cites W2002653737 @default.
- W2156027679 cites W2006334511 @default.
- W2156027679 cites W2009238064 @default.
- W2156027679 cites W2011068062 @default.
- W2156027679 cites W2014146892 @default.
- W2156027679 cites W2014817033 @default.
- W2156027679 cites W2019600152 @default.
- W2156027679 cites W2026465178 @default.
- W2156027679 cites W2027365572 @default.
- W2156027679 cites W2027894878 @default.
- W2156027679 cites W2031922297 @default.
- W2156027679 cites W2031930595 @default.
- W2156027679 cites W2033619275 @default.
- W2156027679 cites W2037149555 @default.
- W2156027679 cites W2040679179 @default.
- W2156027679 cites W2042749830 @default.
- W2156027679 cites W2044490236 @default.
- W2156027679 cites W2044941418 @default.
- W2156027679 cites W2045240569 @default.
- W2156027679 cites W2052540561 @default.
- W2156027679 cites W2060068054 @default.
- W2156027679 cites W2063683246 @default.
- W2156027679 cites W2068906158 @default.
- W2156027679 cites W2069378046 @default.
- W2156027679 cites W2069681995 @default.
- W2156027679 cites W2070887804 @default.
- W2156027679 cites W2073301516 @default.
- W2156027679 cites W2075732583 @default.
- W2156027679 cites W2076591428 @default.
- W2156027679 cites W2076684722 @default.
- W2156027679 cites W2077052143 @default.
- W2156027679 cites W2077436902 @default.
- W2156027679 cites W2077595353 @default.
- W2156027679 cites W2080791829 @default.
- W2156027679 cites W2081143567 @default.
- W2156027679 cites W2085216777 @default.
- W2156027679 cites W2091546358 @default.
- W2156027679 cites W2095332284 @default.
- W2156027679 cites W2098784640 @default.
- W2156027679 cites W2100139219 @default.
- W2156027679 cites W2102825049 @default.
- W2156027679 cites W2105712639 @default.
- W2156027679 cites W2106895921 @default.
- W2156027679 cites W2107405224 @default.
- W2156027679 cites W2108116072 @default.
- W2156027679 cites W2117438690 @default.
- W2156027679 cites W2123971022 @default.
- W2156027679 cites W2127316404 @default.
- W2156027679 cites W2128703019 @default.
- W2156027679 cites W2131823236 @default.
- W2156027679 cites W2132811240 @default.
- W2156027679 cites W2133139112 @default.
- W2156027679 cites W2134985597 @default.
- W2156027679 cites W2137935883 @default.
- W2156027679 cites W2140627360 @default.
- W2156027679 cites W2143681892 @default.
- W2156027679 cites W2146087376 @default.
- W2156027679 cites W2146446321 @default.
- W2156027679 cites W2149509100 @default.
- W2156027679 cites W2151061636 @default.
- W2156027679 cites W2153132589 @default.
- W2156027679 cites W2154439729 @default.
- W2156027679 cites W2155781667 @default.
- W2156027679 cites W2156875872 @default.
- W2156027679 cites W2157172795 @default.
- W2156027679 cites W2157805013 @default.