FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156049473> ?p ?o ?g. }

• W2156049473 endingPage "1276" @default.
• W2156049473 startingPage "1265" @default.
• W2156049473 abstract "Previously, we have suggested that vascular cell adhesion molecule-1 (VCAM-1) and its integrin receptor α4β1 mediate cell–cell interactions important for skeletal myogenesis. Expression of the receptors subsequently subsides in muscle after birth. Here, we examine the mechanism regulating VCAM-1 gene expression in muscle. An enhancer located between the TATA box and the transcriptional start site is responsible for VCAM-1 gene expression in muscle—this element is inactive in endothelial cells where VCAM-1 expression is dependent on nuclear factor κB sites and inflammatory cytokines. We identify interferon regulatory factor-2 (IRF-2), a member of the interferon regulatory factor family, as the enhancer-binding transcription factor and show that expression of IRF-2 parallels that of VCAM-1 during mouse skeletal myogenesis. IRF-2 is not dependent upon cytokines for expression or activity, and it has been shown to act as a repressor in other nonmuscle cell types. We show that the basic repressor motif located near the COOH-terminal of IRF-2 is not active in muscle cells, but instead an acidic region in the center of the molecule functions as a transactivating domain. Although IRF-2 and VCAM-1 expression diminishes on adult muscle fiber, they are retained on myogenic stem cells (satellite cells). These satellite cells proliferate and fuse to regenerate muscle fiber after injury or disease. We present evidence that VCAM-1 on satellite cells mediates their interaction with α4β1(+) leukocytes that invade the muscle after injury or disease. We propose that VCAM-1 on endothelium generally recruits leukocytes to muscle after injury, whereas subsequent interaction with VCAM-1 on regenerating muscle cells focuses the invading leukocytes specifically to the sites of regeneration." @default.
• W2156049473 created "2016-06-24" @default.
• W2156049473 creator A5011923368 @default.
• W2156049473 creator A5016976508 @default.
• W2156049473 creator A5030399664 @default.
• W2156049473 creator A5058951640 @default.
• W2156049473 date "1998-03-09" @default.
• W2156049473 modified "2023-10-01" @default.
• W2156049473 title "Interferon Regulatory Factor-2 Is a Transcriptional Activator in Muscle Where It Regulates Expression of Vascular Cell Adhesion Molecule-1" @default.
• W2156049473 cites W1506569093 @default.
• W2156049473 cites W1545898053 @default.
• W2156049473 cites W1548015936 @default.
• W2156049473 cites W1561486819 @default.
• W2156049473 cites W1581763952 @default.
• W2156049473 cites W172605609 @default.
• W2156049473 cites W1794193241 @default.
• W2156049473 cites W1820553734 @default.
• W2156049473 cites W1857506864 @default.
• W2156049473 cites W1865315112 @default.
• W2156049473 cites W1932606735 @default.
• W2156049473 cites W1939326986 @default.
• W2156049473 cites W1968165158 @default.
• W2156049473 cites W1971755644 @default.
• W2156049473 cites W1974054883 @default.
• W2156049473 cites W1975259832 @default.
• W2156049473 cites W1978624555 @default.
• W2156049473 cites W1982274138 @default.
• W2156049473 cites W1993243592 @default.
• W2156049473 cites W1995213686 @default.
• W2156049473 cites W2001720727 @default.
• W2156049473 cites W2025517694 @default.
• W2156049473 cites W2030528311 @default.
• W2156049473 cites W2038473251 @default.
• W2156049473 cites W2046972996 @default.
• W2156049473 cites W2053049123 @default.
• W2156049473 cites W2054132042 @default.
• W2156049473 cites W2054729189 @default.
• W2156049473 cites W2058964758 @default.
• W2156049473 cites W2061653974 @default.
• W2156049473 cites W2066678496 @default.
• W2156049473 cites W2074079796 @default.
• W2156049473 cites W2086487142 @default.
• W2156049473 cites W2094868974 @default.
• W2156049473 cites W2109478329 @default.
• W2156049473 cites W2126088081 @default.
• W2156049473 cites W2136690547 @default.
• W2156049473 cites W2142678320 @default.
• W2156049473 cites W2153987432 @default.
• W2156049473 cites W2155412985 @default.
• W2156049473 cites W2160796211 @default.
• W2156049473 cites W2163250803 @default.
• W2156049473 cites W2163666397 @default.
• W2156049473 cites W2409963229 @default.
• W2156049473 cites W2423441565 @default.
• W2156049473 cites W4238792058 @default.
• W2156049473 doi "https://doi.org/10.1083/jcb.140.5.1265" @default.
• W2156049473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2132685" @default.
• W2156049473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9490737" @default.
• W2156049473 hasPublicationYear "1998" @default.
• W2156049473 type Work @default.
• W2156049473 sameAs 2156049473 @default.
• W2156049473 citedByCount "155" @default.
• W2156049473 countsByYear W21560494732012 @default.
• W2156049473 countsByYear W21560494732013 @default.
• W2156049473 countsByYear W21560494732014 @default.
• W2156049473 countsByYear W21560494732015 @default.
• W2156049473 countsByYear W21560494732016 @default.
• W2156049473 countsByYear W21560494732017 @default.
• W2156049473 countsByYear W21560494732018 @default.
• W2156049473 countsByYear W21560494732019 @default.
• W2156049473 countsByYear W21560494732020 @default.
• W2156049473 countsByYear W21560494732021 @default.
• W2156049473 countsByYear W21560494732022 @default.
• W2156049473 countsByYear W21560494732023 @default.
• W2156049473 crossrefType "journal-article" @default.
• W2156049473 hasAuthorship W2156049473A5011923368 @default.
• W2156049473 hasAuthorship W2156049473A5016976508 @default.
• W2156049473 hasAuthorship W2156049473A5030399664 @default.
• W2156049473 hasAuthorship W2156049473A5058951640 @default.
• W2156049473 hasBestOaLocation W21560494731 @default.
• W2156049473 hasConcept C104317684 @default.
• W2156049473 hasConcept C111936080 @default.
• W2156049473 hasConcept C134018914 @default.
• W2156049473 hasConcept C1491633281 @default.
• W2156049473 hasConcept C153911025 @default.
• W2156049473 hasConcept C16224149 @default.
• W2156049473 hasConcept C207200792 @default.
• W2156049473 hasConcept C2779959927 @default.
• W2156049473 hasConcept C3763915 @default.
• W2156049473 hasConcept C54355233 @default.
• W2156049473 hasConcept C85789140 @default.
• W2156049473 hasConcept C86339819 @default.
• W2156049473 hasConcept C86803240 @default.
• W2156049473 hasConcept C95444343 @default.
• W2156049473 hasConceptScore W2156049473C104317684 @default.
• W2156049473 hasConceptScore W2156049473C111936080 @default.
• W2156049473 hasConceptScore W2156049473C134018914 @default.
• W2156049473 hasConceptScore W2156049473C1491633281 @default.

• next