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- W2156072936 abstract "Abstract Aim: To prove the hypothesis that exocrine pancreatic function determines resting energy expenditure (REE) in cystic fibrosis (CF). Method: Thirty‐eight CF individuals, 9–34 (19.98 ± 1.0) years, were divided into three groups: Six pancreatic sufficient patients (PS; group A), 21 pancreatic insufficient patients (PI), whose pulmonary function was comparable to that of group A (group B1) and 11 PI patients, whose pulmonary function was significantly worse than that of group A (group B2). REE was estimated by indirect calorimetry. Predicted REE was based on Schofield equations. Measured REE was expressed as % of the predicted. BMI, BMI z‐scores, serum albumin, cholesterol and triglycerides levels were related to REE. Results were expressed as mean ± standard error. Results: Groups B1 and B2 had significantly higher REE% (111.7 ± 2.75% and 119.94 ± 3.8, respectively) as opposed to group A (98.9 ± 3.81%; p = 0.022 and 0.035, respectively) whose REE% was similar to that predicted. REE% between group B1 and B2 was not statistically significant. In groups A, B1 and B, mean FEV1% was 86.33 ± 10.1%, 90.24 ± 4.39%, 44.54 ± 3.47%, respectively, mean BMI was 25.6 ± 2.06, 19.48 ± 0.64 and 20.09 ± 8.8, respectively, BMI z‐scores were 0.75 ± 0.51, –0.52 ± 0.24 and –1.07 ± 0.37, respectively. Significant correlation was demonstrated between REE%, BMI z‐scores and cholesterol levels in group A. Conclusion: Clinically stable CF patients, who had comparable pulmonary function, exhibited increased REE% only in the presence of exocrine pancreatic insufficiency. REE% strongly correlated with BMI z‐scores in pancreatic sufficiency. These findings support the hypothesis that pancreatic rather than pulmonary function may determine nutritional status as well as REE in CF." @default.
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- W2156072936 date "2007-09-14" @default.
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- W2156072936 title "Effect of exocrine pancreatic function on resting energy expenditure in cystic fibrosis" @default.
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- W2156072936 doi "https://doi.org/10.1111/j.1651-2227.2007.00478.x" @default.
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