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- W2156087859 abstract "Aggression is an aspect of social behavior that can be elevated in some individuals with autism spectrum disorder (ASD) and a concern for peers and caregivers. Mutations in Phosphatase and tensin homolog (PTEN), one of several ASD risk factors encoding negative regulators of the PI3K-Akt-mTOR pathway, have been reported in individuals with ASD and comorbid macrocephaly. We previously showed that a mouse model of Pten germline haploinsufficiency (Pten(+/-) ) has selective deficits, primarily in social behavior, along with broad overgrowth of the brain. Here, we further examine the social behavior of Pten(+/-) male mice in the resident-intruder test of aggression, using a comprehensive behavioral analysis to obtain an overall picture of the agonistic, non-agonistic and non-social behavior patterns of Pten(+/-) mice during a free interaction with a novel conspecific. Pten(+/-) male mice were involved in less aggression than their wild-type littermates. Pten(+/-) mice also performed less social investigation, including anogenital investigation and approaching and/or attending to the intruder, which is consistent with our previous finding of decreased sociability in the social approach test. In contrast to these decreases in social behaviors, Pten(+/-) mice showed increased digging. In summary, we report decreased aggression and increased repetitive behavior in Pten(+/-) mice, thus extending our characterization of this model of an ASD risk factor that features brain overgrowth and social deficits." @default.
- W2156087859 created "2016-06-24" @default.
- W2156087859 creator A5008711772 @default.
- W2156087859 creator A5046696253 @default.
- W2156087859 date "2015-02-01" @default.
- W2156087859 modified "2023-09-29" @default.
- W2156087859 title "Decreased aggression and increased repetitive behavior in<i>Pten</i>haploinsufficient mice" @default.
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- W2156087859 doi "https://doi.org/10.1111/gbb.12192" @default.
- W2156087859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25561290" @default.
- W2156087859 hasPublicationYear "2015" @default.
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