FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156088513> ?p ?o ?g. }

• W2156088513 endingPage "301" @default.
• W2156088513 startingPage "294" @default.
• W2156088513 abstract "Recently, the Daf-16 gene has been shown to regulate the lifespan of nematodes and flies. In mammals, the Daf-16 homologues are forkhead (FOXO) transcription factors, of which specific functions have been identified for Foxo1a and Foxo3a. Despite that, their influence on human age-related trajectories and lifespan is unknown. Here, we analysed the effect of genetic variance in Foxo1a and Foxo3a on metabolic profile, age-related diseases, fertility, fecundity and mortality. This study was carried out in the prospective population-based Leiden 85-plus Study, which includes 1245 participants, aged 85 years or more. The mean follow-up time was 4.4 years. Haplotype analyses of Foxo1a revealed that carriers of haplotype 3 'TCA' have higher HbA1c levels (P=0.025) and a 1.14-fold higher all-cause mortality risk (P=0.021). This increase in mortality was attributable to death from diabetes, for which a 2.43-fold increase was observed (P=0.025). The analyses with Foxo3a haplotypes revealed no differences in metabolic profile, fertility or fecundity. However, increased risks of stroke were observed for Foxo3a block-A haplotype 2 'GAGC' (P=0.007) and haplotype 4 'AAAT' (P=0.014) carriers. In addition, the haplotype 2 'GAGC' carriers had a 1.13-fold increased risk for all-cause mortality (P=0.036) and 1.19-fold increased risk for cardiovascular mortality (P=0.052). In conclusion, this study shows that genetic variation in evolutionarily conserved Foxo1a and Foxo3a genes influences lifespan in our study population." @default.
• W2156088513 created "2016-06-24" @default.
• W2156088513 creator A5018565194 @default.
• W2156088513 creator A5035860380 @default.
• W2156088513 creator A5037459627 @default.
• W2156088513 creator A5068163296 @default.
• W2156088513 creator A5071478025 @default.
• W2156088513 creator A5089551782 @default.
• W2156088513 date "2007-01-24" @default.
• W2156088513 modified "2023-10-14" @default.
• W2156088513 title "Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age" @default.
• W2156088513 cites W1572512950 @default.
• W2156088513 cites W1631908837 @default.
• W2156088513 cites W1812816875 @default.
• W2156088513 cites W1966828006 @default.
• W2156088513 cites W2007597705 @default.
• W2156088513 cites W2012134243 @default.
• W2156088513 cites W201521563 @default.
• W2156088513 cites W2016534176 @default.
• W2156088513 cites W2037100222 @default.
• W2156088513 cites W2037341437 @default.
• W2156088513 cites W2038988941 @default.
• W2156088513 cites W2062629127 @default.
• W2156088513 cites W2063098376 @default.
• W2156088513 cites W2065552408 @default.
• W2156088513 cites W2067799923 @default.
• W2156088513 cites W2081359005 @default.
• W2156088513 cites W2084986953 @default.
• W2156088513 cites W2086913931 @default.
• W2156088513 cites W2114338526 @default.
• W2156088513 cites W2114927063 @default.
• W2156088513 cites W2116404316 @default.
• W2156088513 cites W2138665617 @default.
• W2156088513 cites W2149124673 @default.
• W2156088513 cites W2157443158 @default.
• W2156088513 cites W2162434225 @default.
• W2156088513 cites W2162530578 @default.
• W2156088513 cites W2166146113 @default.
• W2156088513 cites W2166693978 @default.
• W2156088513 cites W2170269651 @default.
• W2156088513 cites W2217809488 @default.
• W2156088513 cites W2309376506 @default.
• W2156088513 cites W2315858463 @default.
• W2156088513 cites W4245378753 @default.
• W2156088513 doi "https://doi.org/10.1038/sj.ejhg.5201766" @default.
• W2156088513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17245409" @default.
• W2156088513 hasPublicationYear "2007" @default.
• W2156088513 type Work @default.
• W2156088513 sameAs 2156088513 @default.
• W2156088513 citedByCount "99" @default.
• W2156088513 countsByYear W21560885132012 @default.
• W2156088513 countsByYear W21560885132013 @default.
• W2156088513 countsByYear W21560885132014 @default.
• W2156088513 countsByYear W21560885132015 @default.
• W2156088513 countsByYear W21560885132016 @default.
• W2156088513 countsByYear W21560885132017 @default.
• W2156088513 countsByYear W21560885132018 @default.
• W2156088513 countsByYear W21560885132019 @default.
• W2156088513 countsByYear W21560885132020 @default.
• W2156088513 countsByYear W21560885132021 @default.
• W2156088513 countsByYear W21560885132022 @default.
• W2156088513 crossrefType "journal-article" @default.
• W2156088513 hasAuthorship W2156088513A5018565194 @default.
• W2156088513 hasAuthorship W2156088513A5035860380 @default.
• W2156088513 hasAuthorship W2156088513A5037459627 @default.
• W2156088513 hasAuthorship W2156088513A5068163296 @default.
• W2156088513 hasAuthorship W2156088513A5071478025 @default.
• W2156088513 hasAuthorship W2156088513A5089551782 @default.
• W2156088513 hasBestOaLocation W21560885131 @default.
• W2156088513 hasConcept C104317684 @default.
• W2156088513 hasConcept C144024400 @default.
• W2156088513 hasConcept C149923435 @default.
• W2156088513 hasConcept C180754005 @default.
• W2156088513 hasConcept C197754878 @default.
• W2156088513 hasConcept C2908647359 @default.
• W2156088513 hasConcept C54355233 @default.
• W2156088513 hasConcept C67283656 @default.
• W2156088513 hasConcept C68873052 @default.
• W2156088513 hasConcept C86803240 @default.
• W2156088513 hasConceptScore W2156088513C104317684 @default.
• W2156088513 hasConceptScore W2156088513C144024400 @default.
• W2156088513 hasConceptScore W2156088513C149923435 @default.
• W2156088513 hasConceptScore W2156088513C180754005 @default.
• W2156088513 hasConceptScore W2156088513C197754878 @default.
• W2156088513 hasConceptScore W2156088513C2908647359 @default.
• W2156088513 hasConceptScore W2156088513C54355233 @default.
• W2156088513 hasConceptScore W2156088513C67283656 @default.
• W2156088513 hasConceptScore W2156088513C68873052 @default.
• W2156088513 hasConceptScore W2156088513C86803240 @default.
• W2156088513 hasIssue "3" @default.
• W2156088513 hasLocation W21560885131 @default.
• W2156088513 hasLocation W21560885132 @default.
• W2156088513 hasOpenAccess W2156088513 @default.
• W2156088513 hasPrimaryLocation W21560885131 @default.
• W2156088513 hasRelatedWork W17862870 @default.
• W2156088513 hasRelatedWork W1965237847 @default.
• W2156088513 hasRelatedWork W1979095403 @default.
• W2156088513 hasRelatedWork W2060631033 @default.

• next