FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156089341> ?p ?o ?g. }

• W2156089341 endingPage "13230" @default.
• W2156089341 startingPage "13218" @default.
• W2156089341 abstract "Dengue virus (DEN) is the most prevalent cause of arthropod-borne viral illness in humans. We determined the influence of cellular growth state on DEN type 2 (DEN2) replication in mosquito and human cells, based on the hypothesis that manipulation of cellular growth state will facilitate identification of viral and cellular determinants of productive infection. Comparison of density-arrested and cycling C6/36 Aedes albopictus cells infected with a low-passage DEN2 isolate revealed that cycling cells generated higher virus titers per cell. When C6/36 cells were stalled in S-phase via a thymidine (THY) block, titers of low-passage DEN2 isolates and a high-passage strain, 16681, were increased approximately 30-fold and 10-fold, respectively. Moreover, virus release was earlier in THY-treated cells than in asynchronously cycling cells. Adsorption, entry, genome uncoating, and translation were not responsible for increased titers of virus from S-phase C6/36 cells. In contrast to the 30-fold increase in virus titers, intracellular levels of viral RNA were increased approximately 2-fold, suggesting that the S-phase-responsive step is late in the DEN2 replication cycle. Analysis of viral RNA and protein released from the cells indicated that enhanced DEN2 assembly is largely responsible for increased virus titers produced during S-phase. In contrast to C6/36 cells, DEN2 titers from S-phase human hepatoma cells or primary human fibroblasts were not increased. These results demonstrate a differential response of DEN2 to the mosquito and human cell cycle and provide a framework for detailed studies into the mechanisms mediating virus assembly." @default.
• W2156089341 created "2016-06-24" @default.
• W2156089341 creator A5014973264 @default.
• W2156089341 creator A5027442064 @default.
• W2156089341 date "2005-11-01" @default.
• W2156089341 modified "2023-10-16" @default.
• W2156089341 title "S-Phase-Dependent Enhancement of Dengue Virus 2 Replication in Mosquito Cells, but Not in Human Cells" @default.
• W2156089341 cites W129436490 @default.
• W2156089341 cites W1483565518 @default.
• W2156089341 cites W1494401243 @default.
• W2156089341 cites W1512101434 @default.
• W2156089341 cites W1535238432 @default.
• W2156089341 cites W1545450687 @default.
• W2156089341 cites W1553465574 @default.
• W2156089341 cites W1578085124 @default.
• W2156089341 cites W169285913 @default.
• W2156089341 cites W1950741423 @default.
• W2156089341 cites W1977653880 @default.
• W2156089341 cites W1977697071 @default.
• W2156089341 cites W1984621096 @default.
• W2156089341 cites W1987670262 @default.
• W2156089341 cites W1995206164 @default.
• W2156089341 cites W1997621092 @default.
• W2156089341 cites W2002771588 @default.
• W2156089341 cites W2011233324 @default.
• W2156089341 cites W2013737543 @default.
• W2156089341 cites W2021985719 @default.
• W2156089341 cites W2023879222 @default.
• W2156089341 cites W2037629156 @default.
• W2156089341 cites W2038068681 @default.
• W2156089341 cites W2045377959 @default.
• W2156089341 cites W2047484137 @default.
• W2156089341 cites W2054767423 @default.
• W2156089341 cites W2070065999 @default.
• W2156089341 cites W2073855398 @default.
• W2156089341 cites W2074951994 @default.
• W2156089341 cites W2076942495 @default.
• W2156089341 cites W2077478536 @default.
• W2156089341 cites W2077508243 @default.
• W2156089341 cites W2078441700 @default.
• W2156089341 cites W2082846001 @default.
• W2156089341 cites W2083053974 @default.
• W2156089341 cites W2083475876 @default.
• W2156089341 cites W2086221905 @default.
• W2156089341 cites W2086472454 @default.
• W2156089341 cites W2088844254 @default.
• W2156089341 cites W2089135460 @default.
• W2156089341 cites W2089728964 @default.
• W2156089341 cites W2094939699 @default.
• W2156089341 cites W2097790240 @default.
• W2156089341 cites W2099685714 @default.
• W2156089341 cites W2100689547 @default.
• W2156089341 cites W2117613022 @default.
• W2156089341 cites W2117936709 @default.
• W2156089341 cites W2121789542 @default.
• W2156089341 cites W2123831265 @default.
• W2156089341 cites W2128789431 @default.
• W2156089341 cites W2131112023 @default.
• W2156089341 cites W2132209533 @default.
• W2156089341 cites W2134717733 @default.
• W2156089341 cites W2142590370 @default.
• W2156089341 cites W2149671007 @default.
• W2156089341 cites W2150157306 @default.
• W2156089341 cites W2151849424 @default.
• W2156089341 cites W2157736393 @default.
• W2156089341 cites W2160026842 @default.
• W2156089341 cites W2165669404 @default.
• W2156089341 cites W2331907770 @default.
• W2156089341 cites W2424643416 @default.
• W2156089341 cites W2462677657 @default.
• W2156089341 cites W53138597 @default.
• W2156089341 doi "https://doi.org/10.1128/jvi.79.21.13218-13230.2005" @default.
• W2156089341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1262621" @default.
• W2156089341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16227245" @default.
• W2156089341 hasPublicationYear "2005" @default.
• W2156089341 type Work @default.
• W2156089341 sameAs 2156089341 @default.
• W2156089341 citedByCount "45" @default.
• W2156089341 countsByYear W21560893412012 @default.
• W2156089341 countsByYear W21560893412013 @default.
• W2156089341 countsByYear W21560893412014 @default.
• W2156089341 countsByYear W21560893412015 @default.
• W2156089341 countsByYear W21560893412016 @default.
• W2156089341 countsByYear W21560893412017 @default.
• W2156089341 countsByYear W21560893412018 @default.
• W2156089341 countsByYear W21560893412019 @default.
• W2156089341 countsByYear W21560893412020 @default.
• W2156089341 countsByYear W21560893412021 @default.
• W2156089341 crossrefType "journal-article" @default.
• W2156089341 hasAuthorship W2156089341A5014973264 @default.
• W2156089341 hasAuthorship W2156089341A5027442064 @default.
• W2156089341 hasBestOaLocation W21560893411 @default.
• W2156089341 hasConcept C140704245 @default.
• W2156089341 hasConcept C159047783 @default.
• W2156089341 hasConcept C173758957 @default.
• W2156089341 hasConcept C196594336 @default.
• W2156089341 hasConcept C2522874641 @default.
• W2156089341 hasConcept C2776853612 @default.

• next