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- W2156097130 abstract "Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been recognized as a promising treatment strategy for cocaine overdose and addiction, because CocE is the most efficient native enzyme for metabolizing the naturally occurring cocaine yet identified. A major obstacle to the clinical application of CocE is the thermoinstability of native CocE with a half-life of only a few minutes at physiological temperature (37 degrees C). Here we report thermostable variants of CocE developed through rational design using a novel computational approach followed by in vitro and in vivo studies. This integrated computational-experimental effort has yielded a CocE variant with a approximately 30-fold increase in plasma half-life both in vitro and in vivo. The novel design strategy can be used to develop thermostable mutants of any protein." @default.
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- W2156097130 date "2008-11-05" @default.
- W2156097130 modified "2023-10-09" @default.
- W2156097130 title "Thermostable Variants of Cocaine Esterase for Long-Time Protection against Cocaine Toxicity" @default.
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- W2156097130 doi "https://doi.org/10.1124/mol.108.049486" @default.
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