FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156103653> ?p ?o ?g. }

• W2156103653 endingPage "607" @default.
• W2156103653 startingPage "599" @default.
• W2156103653 abstract "Background We investigated perioperative complications of hepatic arterial infusion chemotherapy preceding major hepatectomy for multiple bilobar colorectal cancer metastases. No consensus exists concerning operative feasibility or perioperative course in patients undergoing major liver resection with neoadjuvant chemotherapy—partly because such chemotherapy is considered hepatotoxic, increasing the risk of postoperative liver failure. Methods Clinicopathologic data were available for 41 consecutive patients with 5 or more bilobar liver metastases from colorectal cancer who underwent major liver resection with or without prior hepatic arterial chemotherapy. Data concerning operative feasibility, postoperative liver function, complication rates, and histologic findings in the non-neoplastic liver were analyzed retrospectively. Results Prehepatectomy and postoperative day 1 platelet counts were lower (P < .01 and P < .05), alkaline phosphatase on postoperative day 3 was higher (P < .01), and prothrombin time on day 1 was more prolonged (P < .01) in the chemotherapy group. No significant difference was seen between groups in intraoperative data, morbidity, or duration of hospitalization. Histologic examination of adjacent non-neoplastic liver confirmed mild to severe fatty degeneration in 91% of the patients undergoing neoadjuvant chemotherapy, compared with 53% in those without neoadjuvant chemotherapy (P = .023). Although the number of neoplasms in chemotherapy patients was greater than that of the other group, overall and disease-free survival rates were comparable between groups. Conclusions Despite mild postoperative liver dysfunction, pre-resection hepatic arterial chemotherapy did not increase morbidity. We investigated perioperative complications of hepatic arterial infusion chemotherapy preceding major hepatectomy for multiple bilobar colorectal cancer metastases. No consensus exists concerning operative feasibility or perioperative course in patients undergoing major liver resection with neoadjuvant chemotherapy—partly because such chemotherapy is considered hepatotoxic, increasing the risk of postoperative liver failure. Clinicopathologic data were available for 41 consecutive patients with 5 or more bilobar liver metastases from colorectal cancer who underwent major liver resection with or without prior hepatic arterial chemotherapy. Data concerning operative feasibility, postoperative liver function, complication rates, and histologic findings in the non-neoplastic liver were analyzed retrospectively. Prehepatectomy and postoperative day 1 platelet counts were lower (P < .01 and P < .05), alkaline phosphatase on postoperative day 3 was higher (P < .01), and prothrombin time on day 1 was more prolonged (P < .01) in the chemotherapy group. No significant difference was seen between groups in intraoperative data, morbidity, or duration of hospitalization. Histologic examination of adjacent non-neoplastic liver confirmed mild to severe fatty degeneration in 91% of the patients undergoing neoadjuvant chemotherapy, compared with 53% in those without neoadjuvant chemotherapy (P = .023). Although the number of neoplasms in chemotherapy patients was greater than that of the other group, overall and disease-free survival rates were comparable between groups. Despite mild postoperative liver dysfunction, pre-resection hepatic arterial chemotherapy did not increase morbidity." @default.
• W2156103653 created "2016-06-24" @default.
• W2156103653 creator A5034453977 @default.
• W2156103653 creator A5043460153 @default.
• W2156103653 creator A5049147704 @default.
• W2156103653 creator A5051132319 @default.
• W2156103653 creator A5060824327 @default.
• W2156103653 creator A5067585940 @default.
• W2156103653 creator A5069641755 @default.
• W2156103653 date "2006-05-01" @default.
• W2156103653 modified "2023-09-27" @default.
• W2156103653 title "Perioperative complications after hepatectomy with or without intra-arterial chemotherapy for bilobar colorectal cancer liver metastases" @default.
• W2156103653 cites W1881505293 @default.
• W2156103653 cites W1907859928 @default.
• W2156103653 cites W1994388745 @default.
• W2156103653 cites W2007267882 @default.
• W2156103653 cites W2009579020 @default.
• W2156103653 cites W2041111833 @default.
• W2156103653 cites W2045316661 @default.
• W2156103653 cites W2046527443 @default.
• W2156103653 cites W2051224942 @default.
• W2156103653 cites W2054265070 @default.
• W2156103653 cites W2066040529 @default.
• W2156103653 cites W2066390717 @default.
• W2156103653 cites W2067482493 @default.
• W2156103653 cites W2073776989 @default.
• W2156103653 cites W2079190855 @default.
• W2156103653 cites W2081183648 @default.
• W2156103653 cites W2084411560 @default.
• W2156103653 cites W2085773264 @default.
• W2156103653 cites W2089653993 @default.
• W2156103653 cites W2105778469 @default.
• W2156103653 cites W2152486489 @default.
• W2156103653 cites W2167265027 @default.
• W2156103653 cites W2171680834 @default.
• W2156103653 cites W2180957408 @default.
• W2156103653 cites W2415533629 @default.
• W2156103653 cites W4366111239 @default.
• W2156103653 cites W88960155 @default.
• W2156103653 doi "https://doi.org/10.1016/j.surg.2005.09.023" @default.
• W2156103653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16701091" @default.
• W2156103653 hasPublicationYear "2006" @default.
• W2156103653 type Work @default.
• W2156103653 sameAs 2156103653 @default.
• W2156103653 citedByCount "19" @default.
• W2156103653 countsByYear W21561036532012 @default.
• W2156103653 countsByYear W21561036532014 @default.
• W2156103653 countsByYear W21561036532016 @default.
• W2156103653 crossrefType "journal-article" @default.
• W2156103653 hasAuthorship W2156103653A5034453977 @default.
• W2156103653 hasAuthorship W2156103653A5043460153 @default.
• W2156103653 hasAuthorship W2156103653A5049147704 @default.
• W2156103653 hasAuthorship W2156103653A5051132319 @default.
• W2156103653 hasAuthorship W2156103653A5060824327 @default.
• W2156103653 hasAuthorship W2156103653A5067585940 @default.
• W2156103653 hasAuthorship W2156103653A5069641755 @default.
• W2156103653 hasConcept C121608353 @default.
• W2156103653 hasConcept C126322002 @default.
• W2156103653 hasConcept C141071460 @default.
• W2156103653 hasConcept C159110652 @default.
• W2156103653 hasConcept C2776694085 @default.
• W2156103653 hasConcept C2776909242 @default.
• W2156103653 hasConcept C2778405590 @default.
• W2156103653 hasConcept C2780434524 @default.
• W2156103653 hasConcept C2992208098 @default.
• W2156103653 hasConcept C31174226 @default.
• W2156103653 hasConcept C526805850 @default.
• W2156103653 hasConcept C71924100 @default.
• W2156103653 hasConcept C81182388 @default.
• W2156103653 hasConcept C90924648 @default.
• W2156103653 hasConceptScore W2156103653C121608353 @default.
• W2156103653 hasConceptScore W2156103653C126322002 @default.
• W2156103653 hasConceptScore W2156103653C141071460 @default.
• W2156103653 hasConceptScore W2156103653C159110652 @default.
• W2156103653 hasConceptScore W2156103653C2776694085 @default.
• W2156103653 hasConceptScore W2156103653C2776909242 @default.
• W2156103653 hasConceptScore W2156103653C2778405590 @default.
• W2156103653 hasConceptScore W2156103653C2780434524 @default.
• W2156103653 hasConceptScore W2156103653C2992208098 @default.
• W2156103653 hasConceptScore W2156103653C31174226 @default.
• W2156103653 hasConceptScore W2156103653C526805850 @default.
• W2156103653 hasConceptScore W2156103653C71924100 @default.
• W2156103653 hasConceptScore W2156103653C81182388 @default.
• W2156103653 hasConceptScore W2156103653C90924648 @default.
• W2156103653 hasIssue "5" @default.
• W2156103653 hasLocation W21561036531 @default.
• W2156103653 hasLocation W21561036532 @default.
• W2156103653 hasOpenAccess W2156103653 @default.
• W2156103653 hasPrimaryLocation W21561036531 @default.
• W2156103653 hasRelatedWork W1979887233 @default.
• W2156103653 hasRelatedWork W2156103653 @default.
• W2156103653 hasRelatedWork W2315696788 @default.
• W2156103653 hasRelatedWork W2321368314 @default.
• W2156103653 hasRelatedWork W2376911415 @default.
• W2156103653 hasRelatedWork W2392134161 @default.
• W2156103653 hasRelatedWork W2474039552 @default.
• W2156103653 hasRelatedWork W2945124548 @default.
• W2156103653 hasRelatedWork W62711790 @default.

• next