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• W2156118511 abstract "To examine whether promoter polymorphisms associated with variation in interleukin-10 (IL-10) production are relevant to the development of rheumatoid arthritis (RA) or Felty's syndrome (FS).DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The promoter region between -533 and - 1120 was amplified by polymerase chain reaction, and polymorphisms detected by restriction enzyme digest or sequence-specific oligonucleotide probing.We found no significant difference in allele or haplotype frequencies between the groups.There is no association between FS or RA and these recently identified IL-10 promoter polymorphisms. Other genetic or environmental factors could explain the alterations in IL-10 levels seen in these conditions." @default.
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• W2156118511 date "1998-09-01" @default.
• W2156118511 modified "2023-09-27" @default.
• W2156118511 title "Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome" @default.
• W2156118511 cites W2148126661 @default.
• W2156118511 doi "https://doi.org/10.1093/rheumatology/37.9.988" @default.
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