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- W2156132248 endingPage "35" @default.
- W2156132248 startingPage "7" @default.
- W2156132248 abstract "Cartilagenous intervertebral discs separate adjacent vertebrae in the spineSpine , allowing modest spinal movements, and distributing compressive load evenly on the vertebral bodies. A central fluid-like nucleus pulposus region is surrounded by a tough laminated annulus fibrosus. Because adult discs lack a blood or nerve supply, cell density is very low and tissue turnover is very slow. Consequently, discs have only a limited ability to heal following injury, and they exhibit a marked and progressive age-related deterioration in material properties. Changes in composition of old discs include fragmentation and loss of proteoglycansProteoglycans , loss of water (especially from the nucleus), and increasing cross-linkingCross-linking of collagensAging Collagen . Functionally, old disc tissues become dry, fibrous, and stiff. Pressure in the nucleus decreases, and stress concentrations grow in the annulus, which becomes more vulnerable to injury and herniation (“slipped disc”). Physical disruption allows nerves and blood vessels to grow into the tissue, which can become a source of chronic back painBack pain . The aging annulus weakens, despite increased collagen cross-linking, because small defects accumulate in its lamellar structure, causing microscopic delamination. Progressive collapse of the annulus can trigger a “degenerative cascade” of events, including spinal osteoarthritis (as load-bearing is transferred to the neural arch), segmental instability, osteophytosis, and senile kyphosis." @default.
- W2156132248 created "2016-06-24" @default.
- W2156132248 creator A5085778643 @default.
- W2156132248 date "2014-10-09" @default.
- W2156132248 modified "2023-10-16" @default.
- W2156132248 title "Intervertebral Disc Tissues" @default.
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