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• W2156169770 abstract "Abstract Aim: To investigate the effect of vitamin K 2 (menatetrenone) treatment on bone mineral density (BMD) and a bone metabolic marker (osteocalcin) in postmenopausal women with osteoporosis living in Indonesia. Methods: A double‐blind randomized placebo‐controlled study of 63 postmenopausal women with osteoporosis. The vitamin K 2 group ( n = 33) received 45 mg menatetrenone and 1500 mg calcium carbonate per day and the control group ( n = 30) received placebo and 1500 mg calcium carbonate per day for 48 weeks. BMD of lumbal spine (L2–L4), osteocalcin (OC) and undercarboxylated OC were measured before, 24 and 48 weeks after initiation of the treatment. Results: After 48 weeks of treatment, the mean percentage change of lumbar BMD in the vitamin K 2 group was significantly higher ( P < 0.05) than that of the control group. The undercarboxylated OC level decreased by 55.9% in the menatetrenone group and 9.3% in the control group compared with the baseline level. The difference between the two groups was significant ( P < 0.01). The adverse events were three minor gastrointestinal cases, which subsided after temporary cessation of therapy. Conclusions: Treatment with 45 mg vitamin K 2 with 1500 mg calcium per day for postmenopausal women with osteoporosis for 48 weeks resulted in a significant increase in lumbar BMD and a significant decrease in undercarboxylated OC levels." @default.
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• W2156169770 date "2006-03-17" @default.
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• W2156169770 title "Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia" @default.
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• W2156169770 doi "https://doi.org/10.1111/j.1447-0756.2006.00386.x" @default.
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