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• W2156171330 abstract "Biochanin-A, a major dietary isoflavone in soy and red clover, possesses anticancer and chemopreventive properties. Induction of apoptosis by naturally occurring dietary agents is an important event for cancer chemoprevention. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis selectively in cancer cells but not in normal cells. Soluble or expressed in immune cells, molecules TRAIL plays a significant role in surveillance and defense mechanisms against tumours. Prostate cancer is an ideal disease for nutritional prevention. The TRAIL-mediated apoptosis pathway in prostate cancer cells is an attractive target for chemopreventive activities of dietary agents. LNCaP and DU145 prostate cancer cells are resistant to TRAIL-induced apoptosis. We showed that biochanin-A markedly augmented TRAIL-induced cytotoxicity and apoptosis in both prostate cancer cell lines. Then, we investigated the mechanisms by which biochanin-A enhanced TRAIL-mediated apoptosis using the LNCaP cell line. The isoflavone sensitized the TRAIL-resistant LNCaP cells through the inhibition of transcription factor NF-κB(p65) activity, increased the expression of the death receptor TRAIL-R2 (DR5), and disrupted mitochondrial membrane potential (ΔΨm). Our study confirmed that biochanin-A overcame TRAIL-resistance by engaging both intrinsic and extrinsic apoptotic pathways and by regulating the NF-κB activity. The results suggested a potential role of biochanin-A in prostate cancer chemoprevention through the enhancement of TRAIL-mediated apoptosis." @default.
• W2156171330 created "2016-06-24" @default.
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• W2156171330 date "2013-04-01" @default.
• W2156171330 modified "2023-10-16" @default.
• W2156171330 title "The dietary isoflavone biochanin-A sensitizes prostate cancer cells to TRAIL-induced apoptosis" @default.
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• W2156171330 cites W1976754594 @default.
• W2156171330 cites W1979603257 @default.
• W2156171330 cites W1992189334 @default.
• W2156171330 cites W1994159353 @default.
• W2156171330 cites W1996621261 @default.
• W2156171330 cites W2002037818 @default.
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• W2156171330 cites W2029000583 @default.
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• W2156171330 cites W2039271361 @default.
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• W2156171330 doi "https://doi.org/10.1016/j.urolonc.2011.01.019" @default.
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