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• W2156179625 startingPage "a009258" @default.
• W2156179625 abstract "Parkinsonism, the clinical term for a disorder with prominent bradykinesia and variable associated extrapyramidal signs and symptoms, is accompanied by degeneration of the nigrostriatal dopaminergic system, with neuronal loss and reactive gliosis in the substantia nigra found at autopsy. Parkinsonism is pathologically heterogeneous, with the most common pathologic substrates related to abnormalities in the presynaptic protein α-synuclein or the microtubule binding protein tau. In idiopathic Parkinson's disease (PD), α-synuclein accumulates in neuronal perikarya (Lewy bodies) and neuronal processes (Lewy neurites). The disease process is multifocal and involves select central nervous system neurons and peripheral autonomic nervous system neurons. The particular set of neurons affected determines nonmotor clinical presentations. Multiple system atrophy (MSA) is the other major α-synucleinopathy. It is also associated with autonomic dysfunction and in some cases with cerebellar signs. The hallmark histopathologic feature of MSA is accumulation of α-synuclein within glial cytoplasmic inclusions (GCI). The most common of the Parkinsonian tauopathies is progressive supranuclear palsy (PSP), which is clinically associated with severe postural instability leading to early falls. The tau pathology of PSP also affects both neurons and glia. Given the population frequency of PD, α-synuclein pathology similar to that in PD, but not accompanied by neuronal loss, is relatively common (10% of people over 65 years of age) in neurologically normal individuals, leading to proposed staging schemes for PD progression. Although MSA-like and PSP-like pathology can be detected in neurologically normal individuals, such cases are too infrequent to permit assessment of patterns of disease progression." @default.
• W2156179625 created "2016-06-24" @default.
• W2156179625 creator A5009533777 @default.
• W2156179625 date "2012-06-20" @default.
• W2156179625 modified "2023-10-14" @default.
• W2156179625 title "Parkinson's Disease and Parkinsonism: Neuropathology" @default.
• W2156179625 cites W114737604 @default.
• W2156179625 cites W1237068170 @default.
• W2156179625 cites W152096304 @default.
• W2156179625 cites W1526946111 @default.
• W2156179625 cites W1541170462 @default.
• W2156179625 cites W1584916210 @default.
• W2156179625 cites W1596038879 @default.
• W2156179625 cites W1880687202 @default.
• W2156179625 cites W191741448 @default.
• W2156179625 cites W1963912731 @default.
• W2156179625 cites W1966760295 @default.
• W2156179625 cites W1968324269 @default.
• W2156179625 cites W1968536863 @default.
• W2156179625 cites W1969541118 @default.
• W2156179625 cites W1972009458 @default.
• W2156179625 cites W1974924674 @default.
• W2156179625 cites W1977315218 @default.
• W2156179625 cites W1979345939 @default.
• W2156179625 cites W1980579913 @default.
• W2156179625 cites W1982866540 @default.
• W2156179625 cites W1983768810 @default.
• W2156179625 cites W1983791859 @default.
• W2156179625 cites W1986748953 @default.
• W2156179625 cites W1991354131 @default.
• W2156179625 cites W1994583626 @default.
• W2156179625 cites W1999385317 @default.
• W2156179625 cites W2002838989 @default.
• W2156179625 cites W2006797111 @default.
• W2156179625 cites W2008704732 @default.
• W2156179625 cites W2010648364 @default.
• W2156179625 cites W2014875179 @default.
• W2156179625 cites W2015628955 @default.
• W2156179625 cites W2015872530 @default.
• W2156179625 cites W2016109926 @default.
• W2156179625 cites W2016863672 @default.
• W2156179625 cites W2019254928 @default.
• W2156179625 cites W2020520661 @default.
• W2156179625 cites W2023048174 @default.
• W2156179625 cites W2023992844 @default.
• W2156179625 cites W2027958854 @default.
• W2156179625 cites W2029704191 @default.
• W2156179625 cites W2033827101 @default.
• W2156179625 cites W2034210468 @default.
• W2156179625 cites W2035318781 @default.
• W2156179625 cites W2037470187 @default.
• W2156179625 cites W2039422672 @default.
• W2156179625 cites W2039449904 @default.
• W2156179625 cites W204017299 @default.
• W2156179625 cites W2044407202 @default.
• W2156179625 cites W2046014998 @default.
• W2156179625 cites W2049801544 @default.
• W2156179625 cites W2050252352 @default.
• W2156179625 cites W2054848243 @default.
• W2156179625 cites W2056539459 @default.
• W2156179625 cites W2059860906 @default.
• W2156179625 cites W2063019912 @default.
• W2156179625 cites W2067439875 @default.
• W2156179625 cites W2075964404 @default.
• W2156179625 cites W2076078146 @default.
• W2156179625 cites W2081325915 @default.
• W2156179625 cites W2085022353 @default.
• W2156179625 cites W2085803660 @default.
• W2156179625 cites W2085875718 @default.
• W2156179625 cites W2090187118 @default.
• W2156179625 cites W2093977564 @default.
• W2156179625 cites W2095436835 @default.
• W2156179625 cites W2099860862 @default.
• W2156179625 cites W2112581313 @default.
• W2156179625 cites W2116832835 @default.
• W2156179625 cites W2120539591 @default.
• W2156179625 cites W2124680543 @default.
• W2156179625 cites W2125619124 @default.
• W2156179625 cites W2127108053 @default.
• W2156179625 cites W2128011583 @default.
• W2156179625 cites W2141483618 @default.
• W2156179625 cites W2143547926 @default.
• W2156179625 cites W2145294211 @default.
• W2156179625 cites W2158817049 @default.
• W2156179625 cites W2165465283 @default.
• W2156179625 cites W2165536207 @default.
• W2156179625 cites W2165976376 @default.
• W2156179625 cites W2168396089 @default.
• W2156179625 cites W2169854709 @default.
• W2156179625 cites W2330566976 @default.
• W2156179625 cites W2400982232 @default.
• W2156179625 cites W2411774636 @default.
• W2156179625 cites W2422132909 @default.
• W2156179625 cites W69591616 @default.
• W2156179625 cites W2112442563 @default.
• W2156179625 doi "https://doi.org/10.1101/cshperspect.a009258" @default.
• W2156179625 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3405828" @default.
• W2156179625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22908195" @default.

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