Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156180868> ?p ?o ?g. }
- W2156180868 endingPage "252" @default.
- W2156180868 startingPage "233" @default.
- W2156180868 abstract "The worldwide distribution and high bioaccumulation potential of pentachlorophenol (PCP) in aquatic organisms imply a high toxicological impact in aquatic systems. Firstly, our investigations show that, similar to mammalian cell lines, PCP can be metabolized to tetrachlorohydroquinone (TCHQ) in the permanent cell line derived from rainbow trout liver cells (RTL-W1). Moreover, we demonstrate that PCP as well as its metabolite TCHQ is capable of influencing the viability of these cells. Three cell viability assays were performed to assess possible cellular targets of these substances. Thus, the cytotoxicity of the PCP-derivative TCHQ was shown for the first time in a fish cell line. Further investigations revealed the involvement of ROS in the cytotoxicity of PCP and its metabolite TCHQ. The observation of oxidative stress provides a plausible explanation for the increased cytotoxicity at higher concentrations especially for PCP and implies possible mechanisms underlying these observations. In addition, antioxidants such as ascorbic acid and quercetin modulate the detrimental effects of PCP and TCHQ whereby both compounds exacerbate the cytotoxic effects of high PCP and TCHQ concentrations." @default.
- W2156180868 created "2016-06-24" @default.
- W2156180868 creator A5020369331 @default.
- W2156180868 creator A5033457189 @default.
- W2156180868 creator A5075200807 @default.
- W2156180868 creator A5088922405 @default.
- W2156180868 date "2014-07-05" @default.
- W2156180868 modified "2023-10-01" @default.
- W2156180868 title "Cytotoxic effects of pentachlorophenol (PCP) and its metabolite tetrachlorohydroquinone (TCHQ) on liver cells are modulated by antioxidants" @default.
- W2156180868 cites W1034850990 @default.
- W2156180868 cites W1153974561 @default.
- W2156180868 cites W129461057 @default.
- W2156180868 cites W1776715443 @default.
- W2156180868 cites W1903245528 @default.
- W2156180868 cites W1963609913 @default.
- W2156180868 cites W1969191668 @default.
- W2156180868 cites W1972144891 @default.
- W2156180868 cites W1980374614 @default.
- W2156180868 cites W1982077281 @default.
- W2156180868 cites W1982348260 @default.
- W2156180868 cites W1988043323 @default.
- W2156180868 cites W1993525331 @default.
- W2156180868 cites W1994419037 @default.
- W2156180868 cites W1995770741 @default.
- W2156180868 cites W1996330566 @default.
- W2156180868 cites W1997518684 @default.
- W2156180868 cites W1997854213 @default.
- W2156180868 cites W2001611840 @default.
- W2156180868 cites W2009455370 @default.
- W2156180868 cites W2014131858 @default.
- W2156180868 cites W2015799647 @default.
- W2156180868 cites W2017528926 @default.
- W2156180868 cites W2021175767 @default.
- W2156180868 cites W2021610255 @default.
- W2156180868 cites W2022501228 @default.
- W2156180868 cites W2022691509 @default.
- W2156180868 cites W2026567232 @default.
- W2156180868 cites W2027282844 @default.
- W2156180868 cites W2029886437 @default.
- W2156180868 cites W2043035748 @default.
- W2156180868 cites W2047734064 @default.
- W2156180868 cites W2056366039 @default.
- W2156180868 cites W2060696438 @default.
- W2156180868 cites W2061476482 @default.
- W2156180868 cites W2082126125 @default.
- W2156180868 cites W2085527914 @default.
- W2156180868 cites W2088686339 @default.
- W2156180868 cites W2089921812 @default.
- W2156180868 cites W2090450248 @default.
- W2156180868 cites W2092595089 @default.
- W2156180868 cites W2092965194 @default.
- W2156180868 cites W2094643555 @default.
- W2156180868 cites W2109867906 @default.
- W2156180868 cites W2110940728 @default.
- W2156180868 cites W21119848 @default.
- W2156180868 cites W2114161898 @default.
- W2156180868 cites W2119399870 @default.
- W2156180868 cites W2130122896 @default.
- W2156180868 cites W2134428402 @default.
- W2156180868 cites W2137529175 @default.
- W2156180868 cites W2147914228 @default.
- W2156180868 cites W2153227556 @default.
- W2156180868 cites W2161511101 @default.
- W2156180868 cites W2168297345 @default.
- W2156180868 cites W2273832281 @default.
- W2156180868 cites W2522912855 @default.
- W2156180868 cites W3188921202 @default.
- W2156180868 doi "https://doi.org/10.1007/s10565-014-9283-4" @default.
- W2156180868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24996998" @default.
- W2156180868 hasPublicationYear "2014" @default.
- W2156180868 type Work @default.
- W2156180868 sameAs 2156180868 @default.
- W2156180868 citedByCount "20" @default.
- W2156180868 countsByYear W21561808682015 @default.
- W2156180868 countsByYear W21561808682016 @default.
- W2156180868 countsByYear W21561808682017 @default.
- W2156180868 countsByYear W21561808682018 @default.
- W2156180868 countsByYear W21561808682019 @default.
- W2156180868 countsByYear W21561808682020 @default.
- W2156180868 countsByYear W21561808682022 @default.
- W2156180868 countsByYear W21561808682023 @default.
- W2156180868 crossrefType "journal-article" @default.
- W2156180868 hasAuthorship W2156180868A5020369331 @default.
- W2156180868 hasAuthorship W2156180868A5033457189 @default.
- W2156180868 hasAuthorship W2156180868A5075200807 @default.
- W2156180868 hasAuthorship W2156180868A5088922405 @default.
- W2156180868 hasBestOaLocation W21561808682 @default.
- W2156180868 hasConcept C107872376 @default.
- W2156180868 hasConcept C109316439 @default.
- W2156180868 hasConcept C1491633281 @default.
- W2156180868 hasConcept C185592680 @default.
- W2156180868 hasConcept C202751555 @default.
- W2156180868 hasConcept C2777477808 @default.
- W2156180868 hasConcept C2779912340 @default.
- W2156180868 hasConcept C53227056 @default.
- W2156180868 hasConcept C54355233 @default.
- W2156180868 hasConcept C55493867 @default.
- W2156180868 hasConcept C81885089 @default.