Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156184123> ?p ?o ?g. }
- W2156184123 endingPage "878" @default.
- W2156184123 startingPage "873" @default.
- W2156184123 abstract "Background: The ability to measure glucose concentration through noninvasive approaches would impact the treatment of diabetes significantly. Polarization-based optical approaches have received considerable interest because of their potential medical applications. Glucose, a chiral molecule, has the ability to rotate the plane of linearly polarized light, commonly referred to as optical activity, as well as changing the refractive index of the media, which therefore affects the overall scattering coefficient in a given media. The magnitude of each effect is related to the concentration of glucose. Although most previous studies have reported on the use of polarimetry in the aqueous humor of the eye because of its nonscattering nature, one would also expect that glucose concentration could be measured in more turbid media such as tissue through a similar approach. This study investigated how each of these effects is correlated to glucose concentration in a physiological range for highly scattering biological media. Methods: A custom-designed imaging polarimeter was used to image highly scattering Intralipid-based media containing different concentrations of glucose. Model formation and glucose prediction were performed through the use of partial least squares (PLS) regression. Further insight into the differences between polarization-based image measurements and encoding of glucose information was provided through the use of principal component analysis (PCA). Results: When coupled with PLS regression, in vitro polarization measurements yielded highly correlated glucose predictions in both calibration and independent validation, 0.999 and 0.998, respectively. Through the use of PCA, it appears that the majority of the image-based signal yielding the most significant glucose information is attributable to changes in the overall scattering coefficient due to glucose concentration and, to a lesser degree, effects of optical activity. Conclusions: This study showed how polarimetric-based imaging coupled with PLS regression can be used to quantify glucose concentration in highly scattering media. Such methods may potentially be able to extend the use of noninvasive in vivo polarimetric measurements, normally acquired in the anterior chamber of the eye, to other preferred sensing sites such as the skin." @default.
- W2156184123 created "2016-06-24" @default.
- W2156184123 creator A5011021642 @default.
- W2156184123 creator A5068242622 @default.
- W2156184123 date "2007-11-01" @default.
- W2156184123 modified "2023-09-24" @default.
- W2156184123 title "Polarization-Based Diffuse Reflectance Imaging for Noninvasive Measurement of Glucose" @default.
- W2156184123 cites W1985323714 @default.
- W2156184123 cites W2020267609 @default.
- W2156184123 cites W2025106282 @default.
- W2156184123 cites W2035553739 @default.
- W2156184123 cites W2038266291 @default.
- W2156184123 cites W2083364983 @default.
- W2156184123 cites W2083963596 @default.
- W2156184123 cites W2092380916 @default.
- W2156184123 cites W2132672139 @default.
- W2156184123 cites W2132992425 @default.
- W2156184123 cites W2144892017 @default.
- W2156184123 cites W2177891231 @default.
- W2156184123 doi "https://doi.org/10.1177/193229680700100611" @default.
- W2156184123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2769677" @default.
- W2156184123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19885159" @default.
- W2156184123 hasPublicationYear "2007" @default.
- W2156184123 type Work @default.
- W2156184123 sameAs 2156184123 @default.
- W2156184123 citedByCount "14" @default.
- W2156184123 countsByYear W21561841232013 @default.
- W2156184123 countsByYear W21561841232014 @default.
- W2156184123 countsByYear W21561841232015 @default.
- W2156184123 countsByYear W21561841232016 @default.
- W2156184123 countsByYear W21561841232017 @default.
- W2156184123 countsByYear W21561841232018 @default.
- W2156184123 countsByYear W21561841232019 @default.
- W2156184123 crossrefType "journal-article" @default.
- W2156184123 hasAuthorship W2156184123A5011021642 @default.
- W2156184123 hasAuthorship W2156184123A5068242622 @default.
- W2156184123 hasBestOaLocation W21561841231 @default.
- W2156184123 hasConcept C105795698 @default.
- W2156184123 hasConcept C120456961 @default.
- W2156184123 hasConcept C120665830 @default.
- W2156184123 hasConcept C121332964 @default.
- W2156184123 hasConcept C134018914 @default.
- W2156184123 hasConcept C136229726 @default.
- W2156184123 hasConcept C147789679 @default.
- W2156184123 hasConcept C154945302 @default.
- W2156184123 hasConcept C156328458 @default.
- W2156184123 hasConcept C161790260 @default.
- W2156184123 hasConcept C185592680 @default.
- W2156184123 hasConcept C186060115 @default.
- W2156184123 hasConcept C191486275 @default.
- W2156184123 hasConcept C192562407 @default.
- W2156184123 hasConcept C205049153 @default.
- W2156184123 hasConcept C22354355 @default.
- W2156184123 hasConcept C27438332 @default.
- W2156184123 hasConcept C28493345 @default.
- W2156184123 hasConcept C33923547 @default.
- W2156184123 hasConcept C41008148 @default.
- W2156184123 hasConcept C42067758 @default.
- W2156184123 hasConcept C48921125 @default.
- W2156184123 hasConcept C55493867 @default.
- W2156184123 hasConcept C555293320 @default.
- W2156184123 hasConcept C65165184 @default.
- W2156184123 hasConcept C71924100 @default.
- W2156184123 hasConcept C77530849 @default.
- W2156184123 hasConcept C82261727 @default.
- W2156184123 hasConcept C86803240 @default.
- W2156184123 hasConceptScore W2156184123C105795698 @default.
- W2156184123 hasConceptScore W2156184123C120456961 @default.
- W2156184123 hasConceptScore W2156184123C120665830 @default.
- W2156184123 hasConceptScore W2156184123C121332964 @default.
- W2156184123 hasConceptScore W2156184123C134018914 @default.
- W2156184123 hasConceptScore W2156184123C136229726 @default.
- W2156184123 hasConceptScore W2156184123C147789679 @default.
- W2156184123 hasConceptScore W2156184123C154945302 @default.
- W2156184123 hasConceptScore W2156184123C156328458 @default.
- W2156184123 hasConceptScore W2156184123C161790260 @default.
- W2156184123 hasConceptScore W2156184123C185592680 @default.
- W2156184123 hasConceptScore W2156184123C186060115 @default.
- W2156184123 hasConceptScore W2156184123C191486275 @default.
- W2156184123 hasConceptScore W2156184123C192562407 @default.
- W2156184123 hasConceptScore W2156184123C205049153 @default.
- W2156184123 hasConceptScore W2156184123C22354355 @default.
- W2156184123 hasConceptScore W2156184123C27438332 @default.
- W2156184123 hasConceptScore W2156184123C28493345 @default.
- W2156184123 hasConceptScore W2156184123C33923547 @default.
- W2156184123 hasConceptScore W2156184123C41008148 @default.
- W2156184123 hasConceptScore W2156184123C42067758 @default.
- W2156184123 hasConceptScore W2156184123C48921125 @default.
- W2156184123 hasConceptScore W2156184123C55493867 @default.
- W2156184123 hasConceptScore W2156184123C555293320 @default.
- W2156184123 hasConceptScore W2156184123C65165184 @default.
- W2156184123 hasConceptScore W2156184123C71924100 @default.
- W2156184123 hasConceptScore W2156184123C77530849 @default.
- W2156184123 hasConceptScore W2156184123C82261727 @default.
- W2156184123 hasConceptScore W2156184123C86803240 @default.
- W2156184123 hasIssue "6" @default.
- W2156184123 hasLocation W21561841231 @default.
- W2156184123 hasLocation W21561841232 @default.