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• W2156233431 abstract "The anti-cancer potential of vitamin K2 (VK2) in hepatoma has gained considerable attention but the underlying mechanisms are unclear. Treatment of HuH7 hepatoma cells with VK2 produced a normal liver phenotype. Following treatment of cells with VK2, there was an increase in gap junctional intercellular communication activity, accompanied by up-regulation of connexin 32 (Cx32), dominantly expressed in normal hepatocyte. In contrast, Cx43 expression was inhibited. Moreover, the effect of VK2 on Cx32 was abolished by over-expression of Cx43. Taken together, we propose that the anti-tumor effect of VK2 is at least partly due to a decrease in Cx43 promoter activity." @default.
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• W2156233431 date "2008-05-01" @default.
• W2156233431 modified "2023-10-11" @default.
• W2156233431 title "Vitamin K2 suppresses malignancy of HuH7 hepatoma cells via inhibition of connexin 43" @default.
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• W2156233431 doi "https://doi.org/10.1016/j.canlet.2007.12.019" @default.
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