FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156277612> ?p ?o ?g. }

• W2156277612 endingPage "429" @default.
• W2156277612 startingPage "424" @default.
• W2156277612 abstract "Gamma-hydroxybutyrate (GHB) is a drug of abuse which induces sedation and euphoria. However, overdoses can severely depress the level of consciousness or can be fatal especially when combined with other substances. Studies have suggested that the GHB-effects are mediated via actions on thalamocortical pathways and local neocortical circuits, although the effect of GHB at the level of single neocortical neurons is not clear. Using whole-cell patch-clamp recordings, we studied the effects of GHB on neocortical neurons in brain slices from 12- to 33-day-old mice. We found that GHB depressed the frequency and amplitude of GABAergic and glutamatergic spontaneous inhibitory and excitatory post-synaptic currents (IPSCs and EPSCs) driven by presynaptic action potential firing, while the amplitude and frequency of Ca(2+) entry-independent miniature IPSCs were not affected. Using minimal stimulation, GHB reduced the probability of release at inhibitory synapses onto neocortical layer 2/3 pyramidal cells. Also, GHB directly hyperpolarized layer 2/3 non-pyramidal cells by up to 11 mV and inhibited action potential firing. All these effects of GHB were mediated via GABA(B)-receptors. In conclusion, GHB activates both pre- and postsynaptic GABA(B)-receptors in neocortical neurons participating in fast synaptic transmission, leading to a powerful depression of neocortical network activity. We propose that GABA(B)-receptor antagonists may be useful in the treatment of acute GHB intoxication." @default.
• W2156277612 created "2016-06-24" @default.
• W2156277612 creator A5017700541 @default.
• W2156277612 creator A5039009716 @default.
• W2156277612 date "2001-05-01" @default.
• W2156277612 modified "2023-10-13" @default.
• W2156277612 title "GHB Depresses Fast Excitatory and Inhibitory Synaptic Transmission via GABAB Receptors in Mouse Neocortical Neurons" @default.
• W2156277612 cites W1480770914 @default.
• W2156277612 cites W1545913212 @default.
• W2156277612 cites W1577542220 @default.
• W2156277612 cites W1944562553 @default.
• W2156277612 cites W1969220120 @default.
• W2156277612 cites W1975470508 @default.
• W2156277612 cites W1975784530 @default.
• W2156277612 cites W1978880787 @default.
• W2156277612 cites W1994799682 @default.
• W2156277612 cites W2004093099 @default.
• W2156277612 cites W2008579214 @default.
• W2156277612 cites W2009202604 @default.
• W2156277612 cites W2016167852 @default.
• W2156277612 cites W2021250865 @default.
• W2156277612 cites W2021524647 @default.
• W2156277612 cites W2025229946 @default.
• W2156277612 cites W2025868325 @default.
• W2156277612 cites W2026968086 @default.
• W2156277612 cites W2038702925 @default.
• W2156277612 cites W2060490717 @default.
• W2156277612 cites W2070787360 @default.
• W2156277612 cites W2071019848 @default.
• W2156277612 cites W2075720494 @default.
• W2156277612 cites W2077974310 @default.
• W2156277612 cites W2082329602 @default.
• W2156277612 cites W2090278597 @default.
• W2156277612 cites W2104298848 @default.
• W2156277612 cites W2107103928 @default.
• W2156277612 cites W2120976620 @default.
• W2156277612 cites W2147476070 @default.
• W2156277612 cites W2157909194 @default.
• W2156277612 cites W2203493408 @default.
• W2156277612 cites W2412056671 @default.
• W2156277612 cites W44752123 @default.
• W2156277612 cites W2416420977 @default.
• W2156277612 doi "https://doi.org/10.1093/cercor/11.5.424" @default.
• W2156277612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11313294" @default.
• W2156277612 hasPublicationYear "2001" @default.
• W2156277612 type Work @default.
• W2156277612 sameAs 2156277612 @default.
• W2156277612 citedByCount "47" @default.
• W2156277612 countsByYear W21562776122013 @default.
• W2156277612 countsByYear W21562776122014 @default.
• W2156277612 countsByYear W21562776122017 @default.
• W2156277612 countsByYear W21562776122019 @default.
• W2156277612 countsByYear W21562776122022 @default.
• W2156277612 crossrefType "journal-article" @default.
• W2156277612 hasAuthorship W2156277612A5017700541 @default.
• W2156277612 hasAuthorship W2156277612A5039009716 @default.
• W2156277612 hasBestOaLocation W21562776121 @default.
• W2156277612 hasConcept C101027131 @default.
• W2156277612 hasConcept C112592302 @default.
• W2156277612 hasConcept C168258287 @default.
• W2156277612 hasConcept C169760540 @default.
• W2156277612 hasConcept C170493617 @default.
• W2156277612 hasConcept C17077164 @default.
• W2156277612 hasConcept C185592680 @default.
• W2156277612 hasConcept C200170125 @default.
• W2156277612 hasConcept C2777222312 @default.
• W2156277612 hasConcept C2779177108 @default.
• W2156277612 hasConcept C2780648746 @default.
• W2156277612 hasConcept C55493867 @default.
• W2156277612 hasConcept C61174792 @default.
• W2156277612 hasConcept C86803240 @default.
• W2156277612 hasConceptScore W2156277612C101027131 @default.
• W2156277612 hasConceptScore W2156277612C112592302 @default.
• W2156277612 hasConceptScore W2156277612C168258287 @default.
• W2156277612 hasConceptScore W2156277612C169760540 @default.
• W2156277612 hasConceptScore W2156277612C170493617 @default.
• W2156277612 hasConceptScore W2156277612C17077164 @default.
• W2156277612 hasConceptScore W2156277612C185592680 @default.
• W2156277612 hasConceptScore W2156277612C200170125 @default.
• W2156277612 hasConceptScore W2156277612C2777222312 @default.
• W2156277612 hasConceptScore W2156277612C2779177108 @default.
• W2156277612 hasConceptScore W2156277612C2780648746 @default.
• W2156277612 hasConceptScore W2156277612C55493867 @default.
• W2156277612 hasConceptScore W2156277612C61174792 @default.
• W2156277612 hasConceptScore W2156277612C86803240 @default.
• W2156277612 hasIssue "5" @default.
• W2156277612 hasLocation W21562776121 @default.
• W2156277612 hasLocation W21562776122 @default.
• W2156277612 hasOpenAccess W2156277612 @default.
• W2156277612 hasPrimaryLocation W21562776121 @default.
• W2156277612 hasRelatedWork W2010236637 @default.
• W2156277612 hasRelatedWork W2026303467 @default.
• W2156277612 hasRelatedWork W2033681203 @default.
• W2156277612 hasRelatedWork W2343691154 @default.
• W2156277612 hasRelatedWork W2927622493 @default.
• W2156277612 hasRelatedWork W3049111871 @default.
• W2156277612 hasRelatedWork W3097202211 @default.
• W2156277612 hasRelatedWork W3122088591 @default.

• next