Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156301166> ?p ?o ?g. }
- W2156301166 endingPage "77" @default.
- W2156301166 startingPage "49" @default.
- W2156301166 abstract "Induction, production, and release of proinflammatory cytokines are essential steps to establish an effective host defense. Cytokines of the interleukin-1 (IL-1) family induce inflammation and regulate T lymphocyte responses while also displaying homeostatic and metabolic activities. With the exception of the IL-1 receptor antagonist, all IL-1 family cytokines lack a signal peptide and require proteolytic processing into an active molecule. One such unique protease is caspase-1, which is activated by protein platforms called the inflammasomes. However, increasing evidence suggests that inflammasomes and caspase-1 are not the only mechanism for processing IL-1 cytokines. IL-1 cytokines are often released as precursors and require extracellular processing for activity. Here we review the inflammasome-independent enzymatic processes that are able to activate IL-1 cytokines, paying special attention to neutrophil-derived serine proteases, which subsequently induce inflammation and modulate host defense. The inflammasome-independent processing of IL-1 cytokines has important consequences for understanding inflammatory diseases, and it impacts the design of IL-1-based modulatory therapies." @default.
- W2156301166 created "2016-06-24" @default.
- W2156301166 creator A5008373339 @default.
- W2156301166 creator A5027955775 @default.
- W2156301166 creator A5028234430 @default.
- W2156301166 creator A5036752858 @default.
- W2156301166 creator A5075304288 @default.
- W2156301166 date "2015-03-21" @default.
- W2156301166 modified "2023-10-06" @default.
- W2156301166 title "Inflammasome-Independent Regulation of IL-1-Family Cytokines" @default.
- W2156301166 cites W136692196 @default.
- W2156301166 cites W1482891313 @default.
- W2156301166 cites W1497331930 @default.
- W2156301166 cites W1502240334 @default.
- W2156301166 cites W1502842924 @default.
- W2156301166 cites W1515994079 @default.
- W2156301166 cites W1519886765 @default.
- W2156301166 cites W1524848610 @default.
- W2156301166 cites W1529674879 @default.
- W2156301166 cites W1533217355 @default.
- W2156301166 cites W1542665725 @default.
- W2156301166 cites W1563133958 @default.
- W2156301166 cites W1573229632 @default.
- W2156301166 cites W1579888339 @default.
- W2156301166 cites W1613736574 @default.
- W2156301166 cites W1777738472 @default.
- W2156301166 cites W1800668800 @default.
- W2156301166 cites W1824528611 @default.
- W2156301166 cites W1927694249 @default.
- W2156301166 cites W1927991005 @default.
- W2156301166 cites W1957948512 @default.
- W2156301166 cites W1964977785 @default.
- W2156301166 cites W1966963462 @default.
- W2156301166 cites W1968564077 @default.
- W2156301166 cites W1968872270 @default.
- W2156301166 cites W1969077093 @default.
- W2156301166 cites W1970278160 @default.
- W2156301166 cites W1972483153 @default.
- W2156301166 cites W1973329998 @default.
- W2156301166 cites W1975032025 @default.
- W2156301166 cites W1976682338 @default.
- W2156301166 cites W1976790296 @default.
- W2156301166 cites W1978007043 @default.
- W2156301166 cites W1979991507 @default.
- W2156301166 cites W1980215718 @default.
- W2156301166 cites W1981837371 @default.
- W2156301166 cites W1982898208 @default.
- W2156301166 cites W1984338631 @default.
- W2156301166 cites W1985538633 @default.
- W2156301166 cites W1987463569 @default.
- W2156301166 cites W1989272448 @default.
- W2156301166 cites W1992841021 @default.
- W2156301166 cites W1993884627 @default.
- W2156301166 cites W1995194119 @default.
- W2156301166 cites W1996729081 @default.
- W2156301166 cites W1997572777 @default.
- W2156301166 cites W1999807078 @default.
- W2156301166 cites W2001946532 @default.
- W2156301166 cites W2003502843 @default.
- W2156301166 cites W2005401885 @default.
- W2156301166 cites W2005529950 @default.
- W2156301166 cites W2007432455 @default.
- W2156301166 cites W2008261126 @default.
- W2156301166 cites W2009004909 @default.
- W2156301166 cites W2011443632 @default.
- W2156301166 cites W2012193854 @default.
- W2156301166 cites W2012270515 @default.
- W2156301166 cites W2012443484 @default.
- W2156301166 cites W2012576192 @default.
- W2156301166 cites W2015449243 @default.
- W2156301166 cites W2019383068 @default.
- W2156301166 cites W2019645050 @default.
- W2156301166 cites W2021064333 @default.
- W2156301166 cites W2021812153 @default.
- W2156301166 cites W2024418426 @default.
- W2156301166 cites W2025355874 @default.
- W2156301166 cites W2025438474 @default.
- W2156301166 cites W2025867998 @default.
- W2156301166 cites W2028193401 @default.
- W2156301166 cites W2028990984 @default.
- W2156301166 cites W2029577492 @default.
- W2156301166 cites W2030023942 @default.
- W2156301166 cites W2031745594 @default.
- W2156301166 cites W2033698154 @default.
- W2156301166 cites W2034490142 @default.
- W2156301166 cites W2035315634 @default.
- W2156301166 cites W2035880703 @default.
- W2156301166 cites W2037472624 @default.
- W2156301166 cites W2039722030 @default.
- W2156301166 cites W2040234391 @default.
- W2156301166 cites W2040675796 @default.
- W2156301166 cites W2042288276 @default.
- W2156301166 cites W2042816890 @default.
- W2156301166 cites W2045015441 @default.
- W2156301166 cites W2046319977 @default.
- W2156301166 cites W2051658957 @default.
- W2156301166 cites W2051771323 @default.
- W2156301166 cites W2052943307 @default.