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- W2156305087 abstract "Numerous pre-clinical studies and clinical trials demonstrated that induction of antibodies to the β-amyloid peptide of 42 residues (Aβ42) elicits therapeutic effects in Alzheimer's disease (AD). However, an active vaccination strategy based on full length Aβ42 is currently hampered by elicitation of T cell pathological autoreactivity. We attempt to improve vaccine efficacy by creating a novel chimeric flu vaccine expressing the small immunodominant B cell epitope of Aβ42. We hypothesized that in elderly people with pre-existing memory Th cells specific to influenza this dual vaccine will simultaneously boost anti-influenza immunity and induce production of therapeutically active anti-Aβ antibodies.Plasmid-based reverse genetics system was used for the rescue of recombinant influenza virus containing immunodominant B cell epitopes of Aβ42 (Aβ1-7/10).Two chimeric flu viruses expressing either 7 or 10 aa of Aβ42 (flu-Aβ1-7 or flu-Aβ1-10) were generated and tested in mice as conventional inactivated vaccines. We demonstrated that this dual vaccine induced therapeutically potent anti-Aβ antibodies and anti-influenza antibodies in mice.We suggest that this strategy might be beneficial for treatment of AD patients as well as for prevention of development of AD pathology in pre-symptomatic individuals while concurrently boosting immunity against influenza." @default.
- W2156305087 created "2016-06-24" @default.
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- W2156305087 date "2011-08-01" @default.
- W2156305087 modified "2023-10-18" @default.
- W2156305087 title "The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease" @default.
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- W2156305087 doi "https://doi.org/10.1186/1479-5876-9-127" @default.
- W2156305087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3162512" @default.
- W2156305087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21806809" @default.
- W2156305087 hasPublicationYear "2011" @default.
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