Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156305854> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2156305854 endingPage "436" @default.
- W2156305854 startingPage "431" @default.
- W2156305854 abstract "In 36 epileptic children treated with primidone alone or in combination with additional anticonvulsants, salivary drug levels were compared in resting (I) and in flow-stimulated (II) saliva and were related to the corresponding serum levels. Primidone levels in saliva I and saliva II were highly correlated (r = 0.97) but were significantly (p less than 0.001) lower in saliva II; the mean difference was -38%. Serum primidone levels were highly correlated to salivary primidone levels both in saliva I (r = 0.92) and in salvia II (r = 0.91). A significant negative correlation could be established between the salivary flow rate and the saliva/serum ratio of primidone, especially in saliva I (r = 0.61; p less than 0.001). The mean saliva I/serum ratio was 1.115, reflecting drug accumulation in resting saliva. The reason primidone accumulates remains unclear. When salivary flow was stimulated, the mean saliva/serum ratio decreased to 0.7, indicating the development of a drug concentration slope from blood to saliva. This is explained by the limited permeation of the drug through cellular membranes due to its rather low lipid solubility. From the data it can be concluded that saliva is suitable for monitoring primidone levels provided the conditions of sample collection are standardized." @default.
- W2156305854 created "2016-06-24" @default.
- W2156305854 creator A5018414802 @default.
- W2156305854 creator A5018452381 @default.
- W2156305854 creator A5042938414 @default.
- W2156305854 date "1979-08-01" @default.
- W2156305854 modified "2023-09-26" @default.
- W2156305854 title "Flow-Dependent Salivary Primidone Levels in Epileptic Children" @default.
- W2156305854 cites W1974935276 @default.
- W2156305854 cites W1991884352 @default.
- W2156305854 cites W2017902123 @default.
- W2156305854 cites W2047386492 @default.
- W2156305854 cites W2061145382 @default.
- W2156305854 cites W2063494721 @default.
- W2156305854 cites W2066584998 @default.
- W2156305854 cites W2067567914 @default.
- W2156305854 cites W2068029838 @default.
- W2156305854 cites W2267732882 @default.
- W2156305854 cites W2270179303 @default.
- W2156305854 cites W2318506057 @default.
- W2156305854 cites W2397471034 @default.
- W2156305854 cites W2885381995 @default.
- W2156305854 doi "https://doi.org/10.1111/j.1528-1157.1979.tb04824.x" @default.
- W2156305854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/477634" @default.
- W2156305854 hasPublicationYear "1979" @default.
- W2156305854 type Work @default.
- W2156305854 sameAs 2156305854 @default.
- W2156305854 citedByCount "17" @default.
- W2156305854 countsByYear W21563058542013 @default.
- W2156305854 countsByYear W21563058542014 @default.
- W2156305854 countsByYear W21563058542018 @default.
- W2156305854 countsByYear W21563058542021 @default.
- W2156305854 countsByYear W21563058542022 @default.
- W2156305854 crossrefType "journal-article" @default.
- W2156305854 hasAuthorship W2156305854A5018414802 @default.
- W2156305854 hasAuthorship W2156305854A5018452381 @default.
- W2156305854 hasAuthorship W2156305854A5042938414 @default.
- W2156305854 hasConcept C118552586 @default.
- W2156305854 hasConcept C126322002 @default.
- W2156305854 hasConcept C134018914 @default.
- W2156305854 hasConcept C185592680 @default.
- W2156305854 hasConcept C2775858608 @default.
- W2156305854 hasConcept C2777992146 @default.
- W2156305854 hasConcept C2778186239 @default.
- W2156305854 hasConcept C504460877 @default.
- W2156305854 hasConcept C71924100 @default.
- W2156305854 hasConceptScore W2156305854C118552586 @default.
- W2156305854 hasConceptScore W2156305854C126322002 @default.
- W2156305854 hasConceptScore W2156305854C134018914 @default.
- W2156305854 hasConceptScore W2156305854C185592680 @default.
- W2156305854 hasConceptScore W2156305854C2775858608 @default.
- W2156305854 hasConceptScore W2156305854C2777992146 @default.
- W2156305854 hasConceptScore W2156305854C2778186239 @default.
- W2156305854 hasConceptScore W2156305854C504460877 @default.
- W2156305854 hasConceptScore W2156305854C71924100 @default.
- W2156305854 hasIssue "4" @default.
- W2156305854 hasLocation W21563058541 @default.
- W2156305854 hasLocation W21563058542 @default.
- W2156305854 hasOpenAccess W2156305854 @default.
- W2156305854 hasPrimaryLocation W21563058541 @default.
- W2156305854 hasRelatedWork W1966504330 @default.
- W2156305854 hasRelatedWork W1979139803 @default.
- W2156305854 hasRelatedWork W2030889776 @default.
- W2156305854 hasRelatedWork W2037631372 @default.
- W2156305854 hasRelatedWork W2040058909 @default.
- W2156305854 hasRelatedWork W2132898409 @default.
- W2156305854 hasRelatedWork W2156305854 @default.
- W2156305854 hasRelatedWork W2748952813 @default.
- W2156305854 hasRelatedWork W2899084033 @default.
- W2156305854 hasRelatedWork W4249176446 @default.
- W2156305854 hasVolume "20" @default.
- W2156305854 isParatext "false" @default.
- W2156305854 isRetracted "false" @default.
- W2156305854 magId "2156305854" @default.
- W2156305854 workType "article" @default.