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• W2156342372 abstract "Similar to astrocytes at CNS synapses, perisynaptic Schwann cells (PSCs) surround nerve terminals at the neuromuscular junction (NMJ). These special teloglial cells are sensitive to neurotransmitters and upregulate glial fibrillary acidic protein (GFAP) when deprived of synaptic activity. We found that activation of muscarinic acetylcholine receptors (mAChRs) at PSCs, but not purinergic (ATP and adenosine) or peptidergic [substance P (SP) and calcitonin gene-related peptide (CGRP)] receptors, prevented this upregulation. When applied onto single PSCs, muscarine evoked Ca 2+ responses that fatigued but prevented upregulation of this glial cytoskeletal protein. Application of ATP onto single PSCs evoked Ca 2+ signals that showed little fatigue, and GFAP upregulation occurred. Thus, Ca 2+ signals alone cannot prevent GFAP upregulation in the PSCs. After blockade of cholinergic receptors by gallamine, neuronal activity was not effective in maintaining low GFAP levels in the perisynaptic glia. Last, immunohistochemistry disclosed mAChRs on PSCs and nearby fibroblasts. Thus, acetylcholine secreted by the nerve terminal acts on the PSCs via mAChRs to regulate GFAP. Cytoskeletal changes may influence perisynaptic glial functions, including growth, remodeling, and modulation of the synapse." @default.
• W2156342372 created "2016-06-24" @default.
• W2156342372 creator A5007523838 @default.
• W2156342372 creator A5039064902 @default.
• W2156342372 creator A5076606994 @default.
• W2156342372 date "1999-05-15" @default.
• W2156342372 modified "2023-10-01" @default.
• W2156342372 title "Muscarinic Control of Cytoskeleton in Perisynaptic Glia" @default.
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• W2156342372 doi "https://doi.org/10.1523/jneurosci.19-10-03836.1999" @default.
• W2156342372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6782737" @default.
• W2156342372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10234016" @default.
• W2156342372 hasPublicationYear "1999" @default.
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