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- W2156355313 abstract "Some 2′-deoxy-1′,2′-seco-D-ribosyl (5′→3′)oligonucleotides (= 1′,2′-seco-DNA), differing from natural DNA only by a bond scission between the centers C(1′) and C(2′), were synthesized and studied in order to compare their structure properties and pairing behavior with those of corresponding natural DNA and homo-DNA oligonucleotides (2′,3′-dideoxy-β-D-glucopyranosyl oligonucleotides). Starting from (−)-D-tartaric acid, 2′-deoxy-1′,2′-secoadenosine derivative 9a and 1′,2′-secothymidine (9b) were obtained in pure crystalline form. Using the phosphoramidite variant of the phosphite-triester method, a dinucleotide monophosphate 1′,2′-seco-d(T2) was synthesized in solution, while oligonucleotides 1′,2′-seco-d[(AT)6], 1′,2′-seco-d(A10) and 1′,2′-seco-d(T10) were prepared on solid phase with either automated or manual techniques. Results of UV- and CD-spectroscopic as well as gel-electrophoretic studies indicated that neither adenine-thymine base pairing (as observed in natural DNA and homo-DNA), nor the adenine-adenine base pairing (as observed in homo-DNA) was effective in 1′,2′-seco-DNA, Furthermore, hybrid pairing was observed neither between 1′.2′-seco-DNA and natural DNA nor between 1′,2′-seco-DNA and homo-DNA." @default.
- W2156355313 created "2016-06-24" @default.
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- W2156355313 date "1997-08-11" @default.
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- W2156355313 title "Synthesis and Properties of 2?-Deoxy-1?,2?-seco-D-ribosyl (5? ? 3?)oligonucleotides (= 1?,2?-seco-DNA) containing adenine and thymine" @default.
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- W2156355313 doi "https://doi.org/10.1002/hlca.19970800513" @default.
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