FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156359315> ?p ?o ?g. }

• W2156359315 endingPage "4300" @default.
• W2156359315 startingPage "4293" @default.
• W2156359315 abstract "ABSTRACT Rapid detection of resistance in Mycobacterium tuberculosis can optimize the efficacy of antituberculous therapy and control the transmission of resistant M. tuberculosis strains. Real-time PCR has minimized the time required to obtain the susceptibility pattern of M. tuberculosis strains, but little effort has been made to adapt this rapid technique to the direct detection of resistance from clinical samples. In this study, we adapted and evaluated a real-time PCR design for direct detection of resistance mutations in clinical respiratory samples. The real-time PCR was evaluated with (i) 11 clinical respiratory samples harboring bacilli resistant to isoniazid (INH) and/or rifampin (RIF), (ii) 10 culture-negative sputa spiked with a set of strains encoding 14 different resistance mutations in 10 independent codons, and (iii) 16 sputa harboring susceptible strains. The results obtained with this real-time PCR design completely agreed with DNA sequencing data. In all sputa harboring resistant M. tuberculosis strains, the mutation encoding resistance was successfully detected. No mutation was detected in any of the susceptible sputa. The test was applied only to smear-positive specimens and succeeded in detecting a bacterial load equivalent to 10 3 CFU/ml in sputum samples (10 acid-fast bacilli/line). The analytical specificity of this method was proved with a set of 14 different non- M. tuberculosis bacteria. This real-time PCR design is an adequate method for the specific and rapid detection of RIF and INH resistance in smear-positive clinical respiratory samples." @default.
• W2156359315 created "2016-06-24" @default.
• W2156359315 creator A5006005815 @default.
• W2156359315 creator A5065136130 @default.
• W2156359315 creator A5075222232 @default.
• W2156359315 creator A5089827499 @default.
• W2156359315 date "2004-11-01" @default.
• W2156359315 modified "2023-10-18" @default.
• W2156359315 title "Rapid Direct Detection of Multiple Rifampin and Isoniazid Resistance Mutations in <i>Mycobacterium tuberculosis</i> in Respiratory Samples by Real-Time PCR" @default.
• W2156359315 cites W1982473418 @default.
• W2156359315 cites W1984486728 @default.
• W2156359315 cites W2018037118 @default.
• W2156359315 cites W2052422622 @default.
• W2156359315 cites W2070172124 @default.
• W2156359315 cites W2105628174 @default.
• W2156359315 cites W2109751189 @default.
• W2156359315 cites W2110078566 @default.
• W2156359315 cites W2110928713 @default.
• W2156359315 cites W2120659509 @default.
• W2156359315 cites W2120820054 @default.
• W2156359315 cites W2122712703 @default.
• W2156359315 cites W2123319934 @default.
• W2156359315 cites W2124229831 @default.
• W2156359315 cites W2127852954 @default.
• W2156359315 cites W2132102084 @default.
• W2156359315 cites W2135117136 @default.
• W2156359315 cites W2150843895 @default.
• W2156359315 cites W2152489884 @default.
• W2156359315 cites W2157364615 @default.
• W2156359315 cites W2159266386 @default.
• W2156359315 cites W2160103842 @default.
• W2156359315 cites W2404713551 @default.
• W2156359315 cites W2418210342 @default.
• W2156359315 cites W3144608771 @default.
• W2156359315 cites W4247874374 @default.
• W2156359315 doi "https://doi.org/10.1128/aac.48.11.4293-4300.2004" @default.
• W2156359315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/525444" @default.
• W2156359315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15504855" @default.
• W2156359315 hasPublicationYear "2004" @default.
• W2156359315 type Work @default.
• W2156359315 sameAs 2156359315 @default.
• W2156359315 citedByCount "67" @default.
• W2156359315 countsByYear W21563593152012 @default.
• W2156359315 countsByYear W21563593152013 @default.
• W2156359315 countsByYear W21563593152014 @default.
• W2156359315 countsByYear W21563593152015 @default.
• W2156359315 countsByYear W21563593152016 @default.
• W2156359315 countsByYear W21563593152017 @default.
• W2156359315 countsByYear W21563593152019 @default.
• W2156359315 countsByYear W21563593152021 @default.
• W2156359315 countsByYear W21563593152022 @default.
• W2156359315 countsByYear W21563593152023 @default.
• W2156359315 crossrefType "journal-article" @default.
• W2156359315 hasAuthorship W2156359315A5006005815 @default.
• W2156359315 hasAuthorship W2156359315A5065136130 @default.
• W2156359315 hasAuthorship W2156359315A5075222232 @default.
• W2156359315 hasAuthorship W2156359315A5089827499 @default.
• W2156359315 hasBestOaLocation W21563593152 @default.
• W2156359315 hasConcept C104317684 @default.
• W2156359315 hasConcept C114851261 @default.
• W2156359315 hasConcept C142724271 @default.
• W2156359315 hasConcept C159047783 @default.
• W2156359315 hasConcept C2776301714 @default.
• W2156359315 hasConcept C2776870249 @default.
• W2156359315 hasConcept C2776967927 @default.
• W2156359315 hasConcept C2777975735 @default.
• W2156359315 hasConcept C2778340795 @default.
• W2156359315 hasConcept C2781069245 @default.
• W2156359315 hasConcept C49105822 @default.
• W2156359315 hasConcept C523546767 @default.
• W2156359315 hasConcept C54355233 @default.
• W2156359315 hasConcept C71924100 @default.
• W2156359315 hasConcept C86803240 @default.
• W2156359315 hasConcept C89423630 @default.
• W2156359315 hasConceptScore W2156359315C104317684 @default.
• W2156359315 hasConceptScore W2156359315C114851261 @default.
• W2156359315 hasConceptScore W2156359315C142724271 @default.
• W2156359315 hasConceptScore W2156359315C159047783 @default.
• W2156359315 hasConceptScore W2156359315C2776301714 @default.
• W2156359315 hasConceptScore W2156359315C2776870249 @default.
• W2156359315 hasConceptScore W2156359315C2776967927 @default.
• W2156359315 hasConceptScore W2156359315C2777975735 @default.
• W2156359315 hasConceptScore W2156359315C2778340795 @default.
• W2156359315 hasConceptScore W2156359315C2781069245 @default.
• W2156359315 hasConceptScore W2156359315C49105822 @default.
• W2156359315 hasConceptScore W2156359315C523546767 @default.
• W2156359315 hasConceptScore W2156359315C54355233 @default.
• W2156359315 hasConceptScore W2156359315C71924100 @default.
• W2156359315 hasConceptScore W2156359315C86803240 @default.
• W2156359315 hasConceptScore W2156359315C89423630 @default.
• W2156359315 hasIssue "11" @default.
• W2156359315 hasLocation W21563593151 @default.
• W2156359315 hasLocation W21563593152 @default.
• W2156359315 hasLocation W21563593153 @default.
• W2156359315 hasLocation W21563593154 @default.
• W2156359315 hasOpenAccess W2156359315 @default.
• W2156359315 hasPrimaryLocation W21563593151 @default.
• W2156359315 hasRelatedWork W2040963208 @default.

• next