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- W2156388230 abstract "The Heikkinen study is a randomised double-blinded study of the effects of six different continuous combined HRT regimens (Indivina, estradiol valerate and medroxyprogesterone acetate, Orion Pharma Finland). Four-hundred-and-nineteen healthy postmenopausal women received 1 or 2 mg oestradiol valerate (E2V) with either 2.5 or 5 mg medroxyprogesterone acetate (MPA).In two groups, the dose of E2V was increased from 1 to 2 mg after six months of treatment. Women recorded their symptoms and were reviewed by clinic staff at regular intervals. After two years, all treatment arms experienced significant improvements in bleeding patterns and climacteric symptoms. After seven years of therapy, adherence continues to be good, with nearly 78% of the women in the 1 mg E2 V groups and almost 60% of the women in the 2 mg E2 V groups remaining in the study. The majority of the women who discontinued therapy were taking the 2 mg E2 V + 2.5 mg MPA dose combination. Improvements in lipid profile and bone mineral density hav..." @default.
- W2156388230 created "2016-06-24" @default.
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- W2156388230 date "2003-12-01" @default.
- W2156388230 modified "2023-09-25" @default.
- W2156388230 title "Long-term adherence to continuous combined HRT: Seven-year update on the Heikkinen study" @default.
- W2156388230 cites W1989785305 @default.
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- W2156388230 doi "https://doi.org/10.1258/136218003773788727" @default.
- W2156388230 hasPublicationYear "2003" @default.
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