FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156390169> ?p ?o ?g. }

• W2156390169 endingPage "1242" @default.
• W2156390169 startingPage "1235" @default.
• W2156390169 abstract "Spiroplasma, small motile wall-less bacteria, are linked by molecular and serological studies to the transmissible spongiform encephalopathies (TSEs), which include scrapie in sheep, chronic wasting disease (CWD) in deer and Creutzfeldt-Jakob disease in humans. In this study, two experiments were undertaken to determine the role of spiroplasma in the pathogenesis of TSE. In experiment 1, Spiroplasma mirum, a rabbit tick isolate that had previously been shown to experimentally induce spongiform encephalopathy in rodents, was inoculated intracranially (IC) into ruminants. S. mirum-inoculated deer manifested clinical signs of TSE after 1.5 to 5.5 months incubation. The deer, as well as sheep and goats, inoculated with S. mirum developed spongiform encephalopathy in a dose-dependent manner. In experiment 2, spiroplasma closely related to S. mirum were isolated from TSE-affected brains via passage in embryonated eggs, and propagated in cell-free M1D media. Spiroplasma spp. isolates from scrapie-affected sheep brain and from CWD-affected deer brain inoculated IC into sheep and goats induced spongiform encephalopathy closely resembling natural TSE in these animals. These data show spiroplasma to be consistently associated with TSE, and able experimentally to cause TSE in ruminant animal models, therein questioning the validity of studies that have concluded the prion, a miss-folded protease-resistant protein that builds up in TSE brains during the course of the disease, to be the sole causal agent. The spiroplasma infection models reported here will be important for investigating factors involved in the pathogenesis of TSE since ruminants are the natural hosts." @default.
• W2156390169 created "2016-06-24" @default.
• W2156390169 creator A5007586649 @default.
• W2156390169 creator A5038136261 @default.
• W2156390169 creator A5039477407 @default.
• W2156390169 creator A5043798032 @default.
• W2156390169 creator A5050131938 @default.
• W2156390169 creator A5051121327 @default.
• W2156390169 creator A5055567075 @default.
• W2156390169 creator A5078329027 @default.
• W2156390169 date "2007-09-01" @default.
• W2156390169 modified "2023-10-12" @default.
• W2156390169 title "Spiroplasma spp. from transmissible spongiform encephalopathy brains or ticks induce spongiform encephalopathy in ruminants" @default.
• W2156390169 cites W1969592318 @default.
• W2156390169 cites W1976767726 @default.
• W2156390169 cites W1978283620 @default.
• W2156390169 cites W1983292653 @default.
• W2156390169 cites W1985067150 @default.
• W2156390169 cites W2012919487 @default.
• W2156390169 cites W2018675827 @default.
• W2156390169 cites W2030353557 @default.
• W2156390169 cites W2032928801 @default.
• W2156390169 cites W2035837637 @default.
• W2156390169 cites W2053890805 @default.
• W2156390169 cites W2056869234 @default.
• W2156390169 cites W2057293794 @default.
• W2156390169 cites W2060413844 @default.
• W2156390169 cites W2063690703 @default.
• W2156390169 cites W2068645378 @default.
• W2156390169 cites W2093158257 @default.
• W2156390169 cites W2094374858 @default.
• W2156390169 cites W2110516310 @default.
• W2156390169 cites W2115239635 @default.
• W2156390169 cites W2132479870 @default.
• W2156390169 cites W2133307731 @default.
• W2156390169 cites W2138735250 @default.
• W2156390169 cites W2481602610 @default.
• W2156390169 cites W2904676311 @default.
• W2156390169 cites W4243502880 @default.
• W2156390169 cites W4250766279 @default.
• W2156390169 doi "https://doi.org/10.1099/jmm.0.47159-0" @default.
• W2156390169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17761489" @default.
• W2156390169 hasPublicationYear "2007" @default.
• W2156390169 type Work @default.
• W2156390169 sameAs 2156390169 @default.
• W2156390169 citedByCount "48" @default.
• W2156390169 countsByYear W21563901692012 @default.
• W2156390169 countsByYear W21563901692013 @default.
• W2156390169 countsByYear W21563901692014 @default.
• W2156390169 countsByYear W21563901692015 @default.
• W2156390169 countsByYear W21563901692017 @default.
• W2156390169 countsByYear W21563901692018 @default.
• W2156390169 countsByYear W21563901692019 @default.
• W2156390169 countsByYear W21563901692020 @default.
• W2156390169 countsByYear W21563901692021 @default.
• W2156390169 countsByYear W21563901692022 @default.
• W2156390169 crossrefType "journal-article" @default.
• W2156390169 hasAuthorship W2156390169A5007586649 @default.
• W2156390169 hasAuthorship W2156390169A5038136261 @default.
• W2156390169 hasAuthorship W2156390169A5039477407 @default.
• W2156390169 hasAuthorship W2156390169A5043798032 @default.
• W2156390169 hasAuthorship W2156390169A5050131938 @default.
• W2156390169 hasAuthorship W2156390169A5051121327 @default.
• W2156390169 hasAuthorship W2156390169A5055567075 @default.
• W2156390169 hasAuthorship W2156390169A5078329027 @default.
• W2156390169 hasBestOaLocation W21563901691 @default.
• W2156390169 hasConcept C129470801 @default.
• W2156390169 hasConcept C142724271 @default.
• W2156390169 hasConcept C159047783 @default.
• W2156390169 hasConcept C2522874641 @default.
• W2156390169 hasConcept C2775881110 @default.
• W2156390169 hasConcept C2776302332 @default.
• W2156390169 hasConcept C2776735649 @default.
• W2156390169 hasConcept C2776797465 @default.
• W2156390169 hasConcept C2778838687 @default.
• W2156390169 hasConcept C2779134260 @default.
• W2156390169 hasConcept C2779728475 @default.
• W2156390169 hasConcept C2781131914 @default.
• W2156390169 hasConcept C3019804061 @default.
• W2156390169 hasConcept C71924100 @default.
• W2156390169 hasConcept C86803240 @default.
• W2156390169 hasConcept C89423630 @default.
• W2156390169 hasConceptScore W2156390169C129470801 @default.
• W2156390169 hasConceptScore W2156390169C142724271 @default.
• W2156390169 hasConceptScore W2156390169C159047783 @default.
• W2156390169 hasConceptScore W2156390169C2522874641 @default.
• W2156390169 hasConceptScore W2156390169C2775881110 @default.
• W2156390169 hasConceptScore W2156390169C2776302332 @default.
• W2156390169 hasConceptScore W2156390169C2776735649 @default.
• W2156390169 hasConceptScore W2156390169C2776797465 @default.
• W2156390169 hasConceptScore W2156390169C2778838687 @default.
• W2156390169 hasConceptScore W2156390169C2779134260 @default.
• W2156390169 hasConceptScore W2156390169C2779728475 @default.
• W2156390169 hasConceptScore W2156390169C2781131914 @default.
• W2156390169 hasConceptScore W2156390169C3019804061 @default.
• W2156390169 hasConceptScore W2156390169C71924100 @default.
• W2156390169 hasConceptScore W2156390169C86803240 @default.
• W2156390169 hasConceptScore W2156390169C89423630 @default.

• next