FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156429510> ?p ?o ?g. }

• W2156429510 endingPage "H1646" @default.
• W2156429510 startingPage "H1638" @default.
• W2156429510 abstract "The present study tested the hypotheses that 1) nitric oxide (NO) is involved in attenuated responses to ANG II in female mice, and 2) there is differential expression of neuronal NO synthase (nNOS) in the subfornical organ (SFO) and paraventricular nucleus (PVN) in response to systemic infusions of ANG II in males vs. females. Aortic blood pressure (BP) was measured in conscious mice with telemetry implants. N G -nitro-l-arginine methyl ester (l-NAME; 100 μg·kg ·−1 day −1 ), an inhibitor of NOS, was administrated into the lateral cerebral ventricle for 14 days before and during ANG II pump implantation. Central infusion of l-NAME augmented the pressor effects of systemic ANG II in females (Δ21.5 ± 2.2 vs. Δ9.2 ± 1.5 mmHg) but not in males (Δ29.4 ± 2.5 vs. Δ30.1 ± 2.5 mmHg). Central administration of N 5 -(1-imino-3-butenyl)-l-ornithine (l-VNIO), a selective nNOS inhibitor, also significantly potentiated the increase in BP induced by ANG II in females (Δ17.5 ± 3.2 vs. Δ9.2 ± 1.5 mmHg). In gonadectomized mice, central l-NAME infusion did not affect the pressor response to ANG II in either males or females. Ganglionic blockade after ANG II infusion resulted in a greater reduction in BP in central l-NAME- or l-VNIO-treated females compared with control females. Western blot analysis of nNOS protein expression indicated that levels were ∼12-fold higher in both the SFO and PVN of intact females compared with those in intact males. Seven days of ANG II treatment resulted in a further increase in nNOS protein expression only in intact females (PVN, to ∼51-fold). Immunohistochemical studies revealed colocalization of nNOS and estrogen receptors in the SFO and PVN. These results suggest that NO attenuates the increase in BP induced by ANG II through reduced sympathetic outflow in females and that increased nNOS protein expression associated with the presence of female sex hormones plays a protective role against ANG II-induced hypertension in female mice." @default.
• W2156429510 created "2016-06-24" @default.
• W2156429510 creator A5001684211 @default.
• W2156429510 creator A5009964656 @default.
• W2156429510 creator A5028103234 @default.
• W2156429510 creator A5055756006 @default.
• W2156429510 creator A5076419479 @default.
• W2156429510 date "2009-11-01" @default.
• W2156429510 modified "2023-10-17" @default.
• W2156429510 title "Protective actions of estrogen on angiotensin II-induced hypertension: role of central nitric oxide" @default.
• W2156429510 cites W1480042661 @default.
• W2156429510 cites W1569744162 @default.
• W2156429510 cites W1595314541 @default.
• W2156429510 cites W1598217995 @default.
• W2156429510 cites W1858498970 @default.
• W2156429510 cites W1967662494 @default.
• W2156429510 cites W1971673570 @default.
• W2156429510 cites W1978998472 @default.
• W2156429510 cites W1997084645 @default.
• W2156429510 cites W1999117743 @default.
• W2156429510 cites W1999266358 @default.
• W2156429510 cites W2002419588 @default.
• W2156429510 cites W2007619703 @default.
• W2156429510 cites W2009452775 @default.
• W2156429510 cites W2011835020 @default.
• W2156429510 cites W2014441685 @default.
• W2156429510 cites W2016595396 @default.
• W2156429510 cites W2029193046 @default.
• W2156429510 cites W2035216511 @default.
• W2156429510 cites W2035464530 @default.
• W2156429510 cites W2038507265 @default.
• W2156429510 cites W2038516051 @default.
• W2156429510 cites W2038573539 @default.
• W2156429510 cites W2047136594 @default.
• W2156429510 cites W2050062696 @default.
• W2156429510 cites W2063109117 @default.
• W2156429510 cites W2068415432 @default.
• W2156429510 cites W2076657893 @default.
• W2156429510 cites W2079141739 @default.
• W2156429510 cites W2083552793 @default.
• W2156429510 cites W2087426603 @default.
• W2156429510 cites W2089466052 @default.
• W2156429510 cites W2089648796 @default.
• W2156429510 cites W2098385297 @default.
• W2156429510 cites W2101220115 @default.
• W2156429510 cites W2107487588 @default.
• W2156429510 cites W2108534782 @default.
• W2156429510 cites W2113438957 @default.
• W2156429510 cites W2113932471 @default.
• W2156429510 cites W2114993802 @default.
• W2156429510 cites W2116127384 @default.
• W2156429510 cites W2117864163 @default.
• W2156429510 cites W2118997371 @default.
• W2156429510 cites W2130930589 @default.
• W2156429510 cites W2136964355 @default.
• W2156429510 cites W2138538255 @default.
• W2156429510 cites W2142242002 @default.
• W2156429510 cites W2150771326 @default.
• W2156429510 cites W2169584791 @default.
• W2156429510 cites W2170544506 @default.
• W2156429510 cites W2238783729 @default.
• W2156429510 cites W2323152300 @default.
• W2156429510 cites W2399796525 @default.
• W2156429510 cites W4238722368 @default.
• W2156429510 doi "https://doi.org/10.1152/ajpheart.00502.2009" @default.
• W2156429510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2781378" @default.
• W2156429510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19734362" @default.
• W2156429510 hasPublicationYear "2009" @default.
• W2156429510 type Work @default.
• W2156429510 sameAs 2156429510 @default.
• W2156429510 citedByCount "46" @default.
• W2156429510 countsByYear W21564295102012 @default.
• W2156429510 countsByYear W21564295102013 @default.
• W2156429510 countsByYear W21564295102014 @default.
• W2156429510 countsByYear W21564295102015 @default.
• W2156429510 countsByYear W21564295102016 @default.
• W2156429510 countsByYear W21564295102017 @default.
• W2156429510 countsByYear W21564295102018 @default.
• W2156429510 countsByYear W21564295102019 @default.
• W2156429510 countsByYear W21564295102020 @default.
• W2156429510 countsByYear W21564295102021 @default.
• W2156429510 countsByYear W21564295102022 @default.
• W2156429510 countsByYear W21564295102023 @default.
• W2156429510 crossrefType "journal-article" @default.
• W2156429510 hasAuthorship W2156429510A5001684211 @default.
• W2156429510 hasAuthorship W2156429510A5009964656 @default.
• W2156429510 hasAuthorship W2156429510A5028103234 @default.
• W2156429510 hasAuthorship W2156429510A5055756006 @default.
• W2156429510 hasAuthorship W2156429510A5076419479 @default.
• W2156429510 hasBestOaLocation W21564295102 @default.
• W2156429510 hasConcept C126322002 @default.
• W2156429510 hasConcept C134018914 @default.
• W2156429510 hasConcept C185592680 @default.
• W2156429510 hasConcept C2775857624 @default.
• W2156429510 hasConcept C2777622882 @default.
• W2156429510 hasConcept C2778921608 @default.
• W2156429510 hasConcept C2908929049 @default.
• W2156429510 hasConcept C519581460 @default.

• next