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- W2156442575 abstract "Poly(ADP-ribose) polymerase [PARP; NAD + ADP-ribosyltransferase; NAD + : poly(adenosine-diphosphate- d -ribosyl)-acceptor ADP- d -ribosyltransferase, EC 2.4.2.30 ] is a zinc-finger DNA-binding protein that detects specifically DNA strand breaks generated by genotoxic agents. To determine its biological function, we have inactivated both alleles by gene targeting in mice. Treatment of PARP −/− mice either by the alkylating agent N -methyl- N -nitrosourea (MNU) or by γ-irradiation revealed an extreme sensitivity and a high genomic instability to both agents. Following whole body γ-irradiation (8 Gy) mutant mice died rapidly from acute radiation toxicity to the small intestine. Mice-derived PARP −/− cells displayed a high sensitivity to MNU exposure: a G 2 /M arrest in mouse embryonic fibroblasts and a rapid apoptotic response and a p53 accumulation were observed in splenocytes. Altogether these results demonstrate that PARP is a survival factor playing an essential and positive role during DNA damage recovery." @default.
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- W2156442575 date "1997-07-08" @default.
- W2156442575 modified "2023-10-04" @default.
- W2156442575 title "Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells" @default.
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- W2156442575 doi "https://doi.org/10.1073/pnas.94.14.7303" @default.
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