FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156451974> ?p ?o ?g. }

• W2156451974 endingPage "6369" @default.
• W2156451974 startingPage "6364" @default.
• W2156451974 abstract "Mantle-cell lymphoma (MCL) is a well-defined subtype of B-cell non-Hodgkin's lymphomas (B-NHL), accounts for approximately 6% of all lymphoid neoplasms, and has a median survival of 3 to 4 years. The genetic hallmark of MCL is the chromosomal translocation t(11;14)(q13;q32) that leads to deregulation and upregulation of Cyclin D1, an important regulator of the G1 phase of the cell cycle. This genetic event is present in virtually all cases of MCL, whereas additional genetic alterations that occur in subsets of MCL have been described. Most of these alterations appear to disturb the cell cycle machinery/interfere with the cellular response to DNA damage, thus making MCL a paradigm for cell cycle and DNA damage response dysregulation in cancer in general. In particular, Cyclin D1 upregulation, genomic amplification of the cyclin-dependent kinase (CDK) -4, deletions of the CDK inhibitor p16(INK4a) and overexpression of BMI-1, a transcriptional repressor of the p16(INK4a) locus, are associated with dysregulation of the cell cycle machinery in MCL. The DNA damage response pathway is affected by frequent alterations of the ataxia-telangiectasia mutated (ATM) kinase as well as occasional inactivation of checkpoint kinase (CHK)-1 and CHK2 that are kinases that act downstream of ATM in response to detection of DNA damage. Moreover, p53 is frequently targeted by alterations in MCL. A recent gene expression profiling study defined the proliferation signature, a quantitative measure of gene expression of proliferation-associated genes as the strongest survival predictor available to date allowing the definition of prognostic MCL subgroups that differ in median survival by more than 5 years." @default.
• W2156451974 created "2016-06-24" @default.
• W2156451974 creator A5022540388 @default.
• W2156451974 creator A5028397596 @default.
• W2156451974 creator A5058191832 @default.
• W2156451974 creator A5059097260 @default.
• W2156451974 creator A5075157221 @default.
• W2156451974 date "2005-09-10" @default.
• W2156451974 modified "2023-10-16" @default.
• W2156451974 title "Pathogenesis of Mantle-Cell Lymphoma: All Oncogenic Roads Lead to Dysregulation of Cell Cycle and DNA Damage Response Pathways" @default.
• W2156451974 cites W1481473039 @default.
• W2156451974 cites W148711857 @default.
• W2156451974 cites W153676044 @default.
• W2156451974 cites W1752089945 @default.
• W2156451974 cites W181471869 @default.
• W2156451974 cites W1974207495 @default.
• W2156451974 cites W1976261939 @default.
• W2156451974 cites W1983348764 @default.
• W2156451974 cites W1986179131 @default.
• W2156451974 cites W1992708996 @default.
• W2156451974 cites W1994066190 @default.
• W2156451974 cites W1994082723 @default.
• W2156451974 cites W2009967055 @default.
• W2156451974 cites W2014170738 @default.
• W2156451974 cites W2029080338 @default.
• W2156451974 cites W2036242721 @default.
• W2156451974 cites W2036861455 @default.
• W2156451974 cites W2039463309 @default.
• W2156451974 cites W2050273277 @default.
• W2156451974 cites W2053839012 @default.
• W2156451974 cites W2059766103 @default.
• W2156451974 cites W2062530202 @default.
• W2156451974 cites W2066848701 @default.
• W2156451974 cites W2076314401 @default.
• W2156451974 cites W2078953772 @default.
• W2156451974 cites W2080459143 @default.
• W2156451974 cites W2082030057 @default.
• W2156451974 cites W2088484198 @default.
• W2156451974 cites W2088498259 @default.
• W2156451974 cites W2104436672 @default.
• W2156451974 cites W2113574608 @default.
• W2156451974 cites W2113576489 @default.
• W2156451974 cites W2118026666 @default.
• W2156451974 cites W2141529421 @default.
• W2156451974 cites W2149362208 @default.
• W2156451974 cites W2159846862 @default.
• W2156451974 cites W2172092345 @default.
• W2156451974 cites W2274928514 @default.
• W2156451974 cites W2303535349 @default.
• W2156451974 cites W2312890915 @default.
• W2156451974 cites W2319826005 @default.
• W2156451974 cites W2342982835 @default.
• W2156451974 cites W2408033184 @default.
• W2156451974 cites W2413121969 @default.
• W2156451974 cites W306697962 @default.
• W2156451974 cites W3149356036 @default.
• W2156451974 cites W4254553660 @default.
• W2156451974 cites W4322701642 @default.
• W2156451974 doi "https://doi.org/10.1200/jco.2005.05.019" @default.
• W2156451974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16155021" @default.
• W2156451974 hasPublicationYear "2005" @default.
• W2156451974 type Work @default.
• W2156451974 sameAs 2156451974 @default.
• W2156451974 citedByCount "186" @default.
• W2156451974 countsByYear W21564519742012 @default.
• W2156451974 countsByYear W21564519742013 @default.
• W2156451974 countsByYear W21564519742014 @default.
• W2156451974 countsByYear W21564519742015 @default.
• W2156451974 countsByYear W21564519742016 @default.
• W2156451974 countsByYear W21564519742017 @default.
• W2156451974 countsByYear W21564519742018 @default.
• W2156451974 countsByYear W21564519742019 @default.
• W2156451974 countsByYear W21564519742020 @default.
• W2156451974 countsByYear W21564519742021 @default.
• W2156451974 countsByYear W21564519742022 @default.
• W2156451974 countsByYear W21564519742023 @default.
• W2156451974 crossrefType "journal-article" @default.
• W2156451974 hasAuthorship W2156451974A5022540388 @default.
• W2156451974 hasAuthorship W2156451974A5028397596 @default.
• W2156451974 hasAuthorship W2156451974A5058191832 @default.
• W2156451974 hasAuthorship W2156451974A5059097260 @default.
• W2156451974 hasAuthorship W2156451974A5075157221 @default.
• W2156451974 hasConcept C105696609 @default.
• W2156451974 hasConcept C124320809 @default.
• W2156451974 hasConcept C143425029 @default.
• W2156451974 hasConcept C1491633281 @default.
• W2156451974 hasConcept C184235292 @default.
• W2156451974 hasConcept C199835354 @default.
• W2156451974 hasConcept C203014093 @default.
• W2156451974 hasConcept C2777525834 @default.
• W2156451974 hasConcept C2779338263 @default.
• W2156451974 hasConcept C29537977 @default.
• W2156451974 hasConcept C50001416 @default.
• W2156451974 hasConcept C502942594 @default.
• W2156451974 hasConcept C54355233 @default.
• W2156451974 hasConcept C552990157 @default.
• W2156451974 hasConcept C86803240 @default.
• W2156451974 hasConcept C95444343 @default.

• next