Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156461736> ?p ?o ?g. }
- W2156461736 endingPage "6623" @default.
- W2156461736 startingPage "6618" @default.
- W2156461736 abstract "ABSTRACT Transmission-blocking vaccines are one strategy for controlling malaria, whereby sexual-stage parasites are inhibited from infecting mosquitoes by human antibodies. To evaluate whether the recently cloned Plasmodium vivax proteins Pvs25 and Pvs28 are candidates for a transmission-blocking vaccine, the molecules were expressed in yeast as secreted recombinant proteins. Mice vaccinated with these proteins adsorbed to aluminum hydroxide developed strong antibody responses against the immunogens, although for Pvs28, this response was genetically restricted. Antisera against both recombinant Pvs25 and Pvs28 recognized the corresponding molecules expressed by cultured sexual-stage parasites isolated from patients with P. vivax malaria. The development of malaria parasites in mosquitoes was completely inhibited when these antisera were ingested with the infected blood meal. Pvs25 and Pvs28, expressed in Saccharomyces cerevisiae , are as yet the only fully characterized transmission-blocking vaccine candidates against P. vivax that induce such a potent antiparasite response." @default.
- W2156461736 created "2016-06-24" @default.
- W2156461736 creator A5011187406 @default.
- W2156461736 creator A5015508892 @default.
- W2156461736 creator A5031801047 @default.
- W2156461736 creator A5036611116 @default.
- W2156461736 creator A5045861719 @default.
- W2156461736 creator A5047545855 @default.
- W2156461736 creator A5072345714 @default.
- W2156461736 creator A5076468695 @default.
- W2156461736 date "2000-12-01" @default.
- W2156461736 modified "2023-10-11" @default.
- W2156461736 title "Antibodies to Malaria Vaccine Candidates Pvs25 and Pvs28 Completely Block the Ability of<i>Plasmodium vivax</i>To Infect Mosquitoes" @default.
- W2156461736 cites W1474579001 @default.
- W2156461736 cites W1562740958 @default.
- W2156461736 cites W1752933373 @default.
- W2156461736 cites W1794003713 @default.
- W2156461736 cites W1901149525 @default.
- W2156461736 cites W1963164531 @default.
- W2156461736 cites W1968930118 @default.
- W2156461736 cites W1970213967 @default.
- W2156461736 cites W1981360965 @default.
- W2156461736 cites W2005376397 @default.
- W2156461736 cites W2009677037 @default.
- W2156461736 cites W2012221104 @default.
- W2156461736 cites W2027757508 @default.
- W2156461736 cites W2031007089 @default.
- W2156461736 cites W2033555823 @default.
- W2156461736 cites W2041693687 @default.
- W2156461736 cites W2050252862 @default.
- W2156461736 cites W2054025724 @default.
- W2156461736 cites W2064962169 @default.
- W2156461736 cites W2080689553 @default.
- W2156461736 cites W2080956225 @default.
- W2156461736 cites W2093008678 @default.
- W2156461736 cites W2093335944 @default.
- W2156461736 cites W2112106111 @default.
- W2156461736 cites W2143806346 @default.
- W2156461736 cites W2160232002 @default.
- W2156461736 cites W2160654020 @default.
- W2156461736 cites W2160758720 @default.
- W2156461736 cites W2161942147 @default.
- W2156461736 cites W2207116045 @default.
- W2156461736 cites W2222913555 @default.
- W2156461736 cites W2428548301 @default.
- W2156461736 doi "https://doi.org/10.1128/iai.68.12.6618-6623.2000" @default.
- W2156461736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/97758" @default.
- W2156461736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11083773" @default.
- W2156461736 hasPublicationYear "2000" @default.
- W2156461736 type Work @default.
- W2156461736 sameAs 2156461736 @default.
- W2156461736 citedByCount "155" @default.
- W2156461736 countsByYear W21564617362012 @default.
- W2156461736 countsByYear W21564617362013 @default.
- W2156461736 countsByYear W21564617362014 @default.
- W2156461736 countsByYear W21564617362015 @default.
- W2156461736 countsByYear W21564617362016 @default.
- W2156461736 countsByYear W21564617362017 @default.
- W2156461736 countsByYear W21564617362018 @default.
- W2156461736 countsByYear W21564617362019 @default.
- W2156461736 countsByYear W21564617362020 @default.
- W2156461736 countsByYear W21564617362021 @default.
- W2156461736 countsByYear W21564617362022 @default.
- W2156461736 countsByYear W21564617362023 @default.
- W2156461736 crossrefType "journal-article" @default.
- W2156461736 hasAuthorship W2156461736A5011187406 @default.
- W2156461736 hasAuthorship W2156461736A5015508892 @default.
- W2156461736 hasAuthorship W2156461736A5031801047 @default.
- W2156461736 hasAuthorship W2156461736A5036611116 @default.
- W2156461736 hasAuthorship W2156461736A5045861719 @default.
- W2156461736 hasAuthorship W2156461736A5047545855 @default.
- W2156461736 hasAuthorship W2156461736A5072345714 @default.
- W2156461736 hasAuthorship W2156461736A5076468695 @default.
- W2156461736 hasBestOaLocation W21564617362 @default.
- W2156461736 hasConcept C104317684 @default.
- W2156461736 hasConcept C136764020 @default.
- W2156461736 hasConcept C159047783 @default.
- W2156461736 hasConcept C159654299 @default.
- W2156461736 hasConcept C203014093 @default.
- W2156461736 hasConcept C2778048844 @default.
- W2156461736 hasConcept C2778371730 @default.
- W2156461736 hasConcept C2778675580 @default.
- W2156461736 hasConcept C2779997623 @default.
- W2156461736 hasConcept C2781034427 @default.
- W2156461736 hasConcept C40767141 @default.
- W2156461736 hasConcept C41008148 @default.
- W2156461736 hasConcept C55493867 @default.
- W2156461736 hasConcept C71928629 @default.
- W2156461736 hasConcept C86803240 @default.
- W2156461736 hasConcept C89423630 @default.
- W2156461736 hasConcept C91523082 @default.
- W2156461736 hasConceptScore W2156461736C104317684 @default.
- W2156461736 hasConceptScore W2156461736C136764020 @default.
- W2156461736 hasConceptScore W2156461736C159047783 @default.
- W2156461736 hasConceptScore W2156461736C159654299 @default.
- W2156461736 hasConceptScore W2156461736C203014093 @default.
- W2156461736 hasConceptScore W2156461736C2778048844 @default.
- W2156461736 hasConceptScore W2156461736C2778371730 @default.