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• W2156462017 abstract "Production of reactive oxygen species (ROS) may be increased during hypoxia in pulmonary arteries. In this study, the role of ROS in the effect of hypoxia on endothelin (ET) type B (ET B ) receptor-mediated vasocontraction in lungs was determined. In rat intrapulmonary (∼0.63 mm ID) arteries, contraction induced by IRL-1620 (a selective ET B receptor agonist) was significantly attenuated after 4 h of hypoxia (30 mmHg Po 2 ) compared with normoxic control (140 mmHg Po 2 ). The effect was abolished by tiron, a scavenger of superoxide anions, but not by polyethylene glycol (PEG)-conjugated catalase, which scavenges H 2 O 2 . The hypoxic effect on ET B receptor-mediated vasoconstriction was also abolished by endothelium denudation but not by nitro-l-arginine and indomethacin. Exposure for 4 h to exogenous superoxide anions, but not H 2 O 2 , attenuated the vasoconstriction induced by IRL-1620. Confocal study showed that hypoxia increased ROS production in pulmonary arteries that were scavenged by PEG-conjugated SOD. In endothelium-intact pulmonary arteries, the ET B receptor protein was reduced after 4 h of exposure to hypoxia, exogenous superoxide anions, or ET-1. BQ-788, a selective ET B receptor antagonist, prevented these effects. ET-1 production was stimulated in endothelium-intact arteries after 4 h of exposure to hypoxia or exogenous superoxide anions. This effect was blunted by PEG-conjugated SOD. These results demonstrate that exposure to hypoxia attenuates ET B receptor-mediated contraction of rat pulmonary arteries. A hypoxia-induced production of superoxide anions may increase ET-1 release from the endothelium and result in downregulation of ET B receptors on smooth muscle." @default.
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• W2156462017 date "2006-03-01" @default.
• W2156462017 modified "2023-10-02" @default.
• W2156462017 title "Hypoxia-induced reactive oxygen species downregulate ET_Breceptor-mediated contraction of rat pulmonary arteries" @default.
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• W2156462017 doi "https://doi.org/10.1152/ajplung.00262.2005" @default.
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