FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156468315> ?p ?o ?g. }

• W2156468315 endingPage "1453" @default.
• W2156468315 startingPage "1445" @default.
• W2156468315 abstract "Vascular smooth muscle cell (VSMC) apoptosis plays an essential role in vascular development and atherosclerosis. Hyperglycemia inhibits VSMC apoptosis, which may contribute to the development of diabetic vasculopathy. In the present study, we analyzed the mechanism of high-glucose–induced anti-apoptotic effect in cultured human aortic smooth muscle cells (HASMCs). Compared with normoglycemia, exposure of HASMCs to hyperglycemia but not mannitol significantly increased sphingosine kinase 1 (SK1) activity but not SK2 activity. This increase was inhibited by protein kinase C (PKC) inhibitor GF109203X, the antioxidant N-acetylcysteine, and the reduced form of glutathione. The mechanism of SK1 activation by high glucose involves plasma membrane translocation. In addition, hyperglycemia markedly inhibited serum withdrawal–induced apoptosis in HASMCs. Importantly, inhibition of SK1 by either a competitive inhibitor N′,N′-dimethylsphingosine or expression of dominant-negative mutant of SK1(G82D) or specific small interference RNA knockdown substantially attenuated hyperglycemia-induced anti-apoptotic effect and anti-apoptotic protein Bcl-2 expression in HASMCs. Moreover, SK1-mediated anti-apoptotic effect requires the intracellular effects of sphingosine-1-phosphate. We conclude that hyperglycemia stimulates SK1 activity via PKC- and oxidative stress–dependent pathways, leading to decreased apoptosis in HASMCs. Taken together, these observations have important implications for understanding the roles of the SK1 signaling pathway in the pathogenesis of diabetic vasculopathy." @default.
• W2156468315 created "2016-06-24" @default.
• W2156468315 creator A5030148992 @default.
• W2156468315 creator A5034547272 @default.
• W2156468315 creator A5054941782 @default.
• W2156468315 creator A5075828988 @default.
• W2156468315 date "2007-05-01" @default.
• W2156468315 modified "2023-10-03" @default.
• W2156468315 title "Activation of Sphingosine Kinase-1 Mediates Inhibition of Vascular Smooth Muscle Cell Apoptosis by Hyperglycemia" @default.
• W2156468315 cites W1546174692 @default.
• W2156468315 cites W1973573934 @default.
• W2156468315 cites W1975304621 @default.
• W2156468315 cites W1981852211 @default.
• W2156468315 cites W1988176697 @default.
• W2156468315 cites W1993449698 @default.
• W2156468315 cites W1994248356 @default.
• W2156468315 cites W1996192399 @default.
• W2156468315 cites W1997819209 @default.
• W2156468315 cites W1997958903 @default.
• W2156468315 cites W2021491454 @default.
• W2156468315 cites W2022770236 @default.
• W2156468315 cites W2035620169 @default.
• W2156468315 cites W2047231993 @default.
• W2156468315 cites W2061672786 @default.
• W2156468315 cites W2070692648 @default.
• W2156468315 cites W2072289636 @default.
• W2156468315 cites W2075468442 @default.
• W2156468315 cites W2077548365 @default.
• W2156468315 cites W2081529705 @default.
• W2156468315 cites W2084654786 @default.
• W2156468315 cites W2089106470 @default.
• W2156468315 cites W2091851800 @default.
• W2156468315 cites W2099436251 @default.
• W2156468315 cites W2105218146 @default.
• W2156468315 cites W2105927444 @default.
• W2156468315 cites W2106643241 @default.
• W2156468315 cites W2108116605 @default.
• W2156468315 cites W2109168147 @default.
• W2156468315 cites W2110388058 @default.
• W2156468315 cites W2111478784 @default.
• W2156468315 cites W2115424453 @default.
• W2156468315 cites W2118174385 @default.
• W2156468315 cites W2136003609 @default.
• W2156468315 cites W2137159939 @default.
• W2156468315 cites W2137302404 @default.
• W2156468315 cites W2139130558 @default.
• W2156468315 cites W2139577664 @default.
• W2156468315 cites W2139881033 @default.
• W2156468315 cites W2142035879 @default.
• W2156468315 cites W2143843643 @default.
• W2156468315 cites W2144535813 @default.
• W2156468315 cites W2146837950 @default.
• W2156468315 cites W2147336880 @default.
• W2156468315 cites W2148049720 @default.
• W2156468315 cites W2150592919 @default.
• W2156468315 cites W2162108926 @default.
• W2156468315 cites W2163493668 @default.
• W2156468315 cites W4254085287 @default.
• W2156468315 doi "https://doi.org/10.2337/db06-1418" @default.
• W2156468315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17325258" @default.
• W2156468315 hasPublicationYear "2007" @default.
• W2156468315 type Work @default.
• W2156468315 sameAs 2156468315 @default.
• W2156468315 citedByCount "26" @default.
• W2156468315 countsByYear W21564683152012 @default.
• W2156468315 countsByYear W21564683152013 @default.
• W2156468315 countsByYear W21564683152014 @default.
• W2156468315 countsByYear W21564683152015 @default.
• W2156468315 countsByYear W21564683152017 @default.
• W2156468315 countsByYear W21564683152018 @default.
• W2156468315 countsByYear W21564683152021 @default.
• W2156468315 countsByYear W21564683152022 @default.
• W2156468315 crossrefType "journal-article" @default.
• W2156468315 hasAuthorship W2156468315A5030148992 @default.
• W2156468315 hasAuthorship W2156468315A5034547272 @default.
• W2156468315 hasAuthorship W2156468315A5054941782 @default.
• W2156468315 hasAuthorship W2156468315A5075828988 @default.
• W2156468315 hasBestOaLocation W21564683151 @default.
• W2156468315 hasConcept C104317684 @default.
• W2156468315 hasConcept C126322002 @default.
• W2156468315 hasConcept C127561419 @default.
• W2156468315 hasConcept C134018914 @default.
• W2156468315 hasConcept C170493617 @default.
• W2156468315 hasConcept C184235292 @default.
• W2156468315 hasConcept C185592680 @default.
• W2156468315 hasConcept C190283241 @default.
• W2156468315 hasConcept C195794163 @default.
• W2156468315 hasConcept C2776596873 @default.
• W2156468315 hasConcept C2777550365 @default.
• W2156468315 hasConcept C2777700496 @default.
• W2156468315 hasConcept C2778703144 @default.
• W2156468315 hasConcept C2779395532 @default.
• W2156468315 hasConcept C2992686903 @default.
• W2156468315 hasConcept C55493867 @default.
• W2156468315 hasConcept C62478195 @default.
• W2156468315 hasConcept C71924100 @default.
• W2156468315 hasConcept C86803240 @default.
• W2156468315 hasConcept C95444343 @default.

• next