Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156500667> ?p ?o ?g. }
- W2156500667 endingPage "6256" @default.
- W2156500667 startingPage "6250" @default.
- W2156500667 abstract "Abstract Both IgG and IgA Abs have been implicated in host defense against bacterial infections, although their relative contributions remain unclear. We generated a unique panel of human chimeric Abs of all human IgG and IgA subclasses with identical V genes against porin A, a major subcapsular protein Ag of Neisseria meningitidis and a vaccine candidate. Chimeric Abs were produced in baby hamster kidney cells, and IgA-producing clones were cotransfected with human J chain and/or human secretory component. Although IgG (isotypes IgG1–3) mediated efficient complement-dependent lysis, IgA was unable to. However, IgA proved equally active to IgG in stimulating polymorphonuclear leukocyte respiratory burst. Remarkably, although porin-specific monomeric, dimeric, and polymeric IgA triggered efficient phagocytosis, secretory IgA did not. These studies reveal unique and nonoverlapping roles for IgG and IgA Abs in defense against meningococcal infections." @default.
- W2156500667 created "2016-06-24" @default.
- W2156500667 creator A5001994531 @default.
- W2156500667 creator A5011769862 @default.
- W2156500667 creator A5026032024 @default.
- W2156500667 creator A5031605509 @default.
- W2156500667 creator A5042692933 @default.
- W2156500667 creator A5051006769 @default.
- W2156500667 creator A5060480065 @default.
- W2156500667 creator A5061315678 @default.
- W2156500667 creator A5067063383 @default.
- W2156500667 creator A5076243271 @default.
- W2156500667 creator A5089492935 @default.
- W2156500667 date "2001-05-15" @default.
- W2156500667 modified "2023-10-18" @default.
- W2156500667 title "Activity of Human IgG and IgA Subclasses in Immune Defense Against <i>Neisseria meningitidis</i> Serogroup B" @default.
- W2156500667 cites W1533677953 @default.
- W2156500667 cites W1595519258 @default.
- W2156500667 cites W1965562708 @default.
- W2156500667 cites W1973109814 @default.
- W2156500667 cites W1977011387 @default.
- W2156500667 cites W1984041785 @default.
- W2156500667 cites W1984276314 @default.
- W2156500667 cites W1991192668 @default.
- W2156500667 cites W1991844560 @default.
- W2156500667 cites W1993552295 @default.
- W2156500667 cites W1994411591 @default.
- W2156500667 cites W2022660570 @default.
- W2156500667 cites W2023324449 @default.
- W2156500667 cites W2036053465 @default.
- W2156500667 cites W204218960 @default.
- W2156500667 cites W2042304536 @default.
- W2156500667 cites W2043372168 @default.
- W2156500667 cites W2044099387 @default.
- W2156500667 cites W2044128581 @default.
- W2156500667 cites W2046267384 @default.
- W2156500667 cites W2056814311 @default.
- W2156500667 cites W2064074509 @default.
- W2156500667 cites W2068057044 @default.
- W2156500667 cites W2106833014 @default.
- W2156500667 cites W2112071807 @default.
- W2156500667 cites W2112987098 @default.
- W2156500667 cites W2115350923 @default.
- W2156500667 cites W2116130694 @default.
- W2156500667 cites W2128813598 @default.
- W2156500667 cites W2134640618 @default.
- W2156500667 cites W2138489941 @default.
- W2156500667 cites W2139887355 @default.
- W2156500667 cites W2160899789 @default.
- W2156500667 cites W2275214593 @default.
- W2156500667 cites W2323159543 @default.
- W2156500667 cites W4250688128 @default.
- W2156500667 cites W4313311152 @default.
- W2156500667 cites W4320800378 @default.
- W2156500667 doi "https://doi.org/10.4049/jimmunol.166.10.6250" @default.
- W2156500667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11342648" @default.
- W2156500667 hasPublicationYear "2001" @default.
- W2156500667 type Work @default.
- W2156500667 sameAs 2156500667 @default.
- W2156500667 citedByCount "121" @default.
- W2156500667 countsByYear W21565006672012 @default.
- W2156500667 countsByYear W21565006672013 @default.
- W2156500667 countsByYear W21565006672014 @default.
- W2156500667 countsByYear W21565006672015 @default.
- W2156500667 countsByYear W21565006672016 @default.
- W2156500667 countsByYear W21565006672017 @default.
- W2156500667 countsByYear W21565006672018 @default.
- W2156500667 countsByYear W21565006672019 @default.
- W2156500667 countsByYear W21565006672020 @default.
- W2156500667 countsByYear W21565006672021 @default.
- W2156500667 countsByYear W21565006672022 @default.
- W2156500667 countsByYear W21565006672023 @default.
- W2156500667 crossrefType "journal-article" @default.
- W2156500667 hasAuthorship W2156500667A5001994531 @default.
- W2156500667 hasAuthorship W2156500667A5011769862 @default.
- W2156500667 hasAuthorship W2156500667A5026032024 @default.
- W2156500667 hasAuthorship W2156500667A5031605509 @default.
- W2156500667 hasAuthorship W2156500667A5042692933 @default.
- W2156500667 hasAuthorship W2156500667A5051006769 @default.
- W2156500667 hasAuthorship W2156500667A5060480065 @default.
- W2156500667 hasAuthorship W2156500667A5061315678 @default.
- W2156500667 hasAuthorship W2156500667A5067063383 @default.
- W2156500667 hasAuthorship W2156500667A5076243271 @default.
- W2156500667 hasAuthorship W2156500667A5089492935 @default.
- W2156500667 hasBestOaLocation W21565006671 @default.
- W2156500667 hasConcept C104317684 @default.
- W2156500667 hasConcept C146587185 @default.
- W2156500667 hasConcept C159047783 @default.
- W2156500667 hasConcept C159654299 @default.
- W2156500667 hasConcept C203014093 @default.
- W2156500667 hasConcept C2777317804 @default.
- W2156500667 hasConcept C2778458888 @default.
- W2156500667 hasConcept C2779102806 @default.
- W2156500667 hasConcept C2780898057 @default.
- W2156500667 hasConcept C523546767 @default.
- W2156500667 hasConcept C54355233 @default.
- W2156500667 hasConcept C547475151 @default.
- W2156500667 hasConcept C86803240 @default.