Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156507154> ?p ?o ?g. }
- W2156507154 endingPage "3111" @default.
- W2156507154 startingPage "3104" @default.
- W2156507154 abstract "Membrane protein insertion and topogenesis generally occur at the Sec61 translocon in the endoplasmic reticulum membrane. During this process, membrane spanning segments may adopt two distinct orientations with either their N- or C-terminus translocated into the ER lumen. While different topogenic determinants in membrane proteins, such as flanking charges, polypeptide folding, and hydrophobicity, have been identified, it is not well understood how the translocon and/or associated components decode them. Here we present evidence that the translocon-associated protein (TRAP) complex is involved in membrane protein topogenesis in vivo. Small interfering RNA (siRNA)-mediated silencing of the TRAP complex in HeLa cells enhanced the topology effect of mutating the flanking charges of a signal-anchor, but not of increasing signal hydrophobicity. The results suggest a role of the TRAP complex in moderating the 'positive-inside' rule." @default.
- W2156507154 created "2016-06-24" @default.
- W2156507154 creator A5014731366 @default.
- W2156507154 creator A5048312131 @default.
- W2156507154 creator A5058554199 @default.
- W2156507154 creator A5061756250 @default.
- W2156507154 creator A5075659873 @default.
- W2156507154 date "2013-12-01" @default.
- W2156507154 modified "2023-10-12" @default.
- W2156507154 title "TRAP assists membrane protein topogenesis at the mammalian ER membrane" @default.
- W2156507154 cites W1636142535 @default.
- W2156507154 cites W1640153047 @default.
- W2156507154 cites W1966308807 @default.
- W2156507154 cites W1971447046 @default.
- W2156507154 cites W1981610784 @default.
- W2156507154 cites W1982573893 @default.
- W2156507154 cites W1982590931 @default.
- W2156507154 cites W1983178254 @default.
- W2156507154 cites W1985899857 @default.
- W2156507154 cites W1990054050 @default.
- W2156507154 cites W1991467177 @default.
- W2156507154 cites W1998092533 @default.
- W2156507154 cites W1999031532 @default.
- W2156507154 cites W2000456126 @default.
- W2156507154 cites W2017498808 @default.
- W2156507154 cites W2017648725 @default.
- W2156507154 cites W2020258831 @default.
- W2156507154 cites W2020558560 @default.
- W2156507154 cites W2022300284 @default.
- W2156507154 cites W2025859600 @default.
- W2156507154 cites W2035621280 @default.
- W2156507154 cites W2037666736 @default.
- W2156507154 cites W2039904880 @default.
- W2156507154 cites W2047524608 @default.
- W2156507154 cites W2059043988 @default.
- W2156507154 cites W2061492608 @default.
- W2156507154 cites W2062918974 @default.
- W2156507154 cites W2073726493 @default.
- W2156507154 cites W2075922914 @default.
- W2156507154 cites W2077345869 @default.
- W2156507154 cites W2079114119 @default.
- W2156507154 cites W2083979787 @default.
- W2156507154 cites W2086481638 @default.
- W2156507154 cites W2087069728 @default.
- W2156507154 cites W2107369553 @default.
- W2156507154 cites W2107586670 @default.
- W2156507154 cites W2108193414 @default.
- W2156507154 cites W2110097278 @default.
- W2156507154 cites W2114792768 @default.
- W2156507154 cites W2116023885 @default.
- W2156507154 cites W2118016880 @default.
- W2156507154 cites W2121277080 @default.
- W2156507154 cites W2128207929 @default.
- W2156507154 cites W2130370138 @default.
- W2156507154 cites W2132046610 @default.
- W2156507154 cites W2135593976 @default.
- W2156507154 cites W2139037625 @default.
- W2156507154 cites W2141300290 @default.
- W2156507154 cites W2145932631 @default.
- W2156507154 cites W2156163052 @default.
- W2156507154 cites W2156574575 @default.
- W2156507154 cites W2158019890 @default.
- W2156507154 cites W2158397184 @default.
- W2156507154 cites W2162824898 @default.
- W2156507154 cites W2167124550 @default.
- W2156507154 cites W2171147265 @default.
- W2156507154 cites W2171903383 @default.
- W2156507154 cites W245256937 @default.
- W2156507154 doi "https://doi.org/10.1016/j.bbamcr.2013.08.018" @default.
- W2156507154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24013069" @default.
- W2156507154 hasPublicationYear "2013" @default.
- W2156507154 type Work @default.
- W2156507154 sameAs 2156507154 @default.
- W2156507154 citedByCount "53" @default.
- W2156507154 countsByYear W21565071542013 @default.
- W2156507154 countsByYear W21565071542014 @default.
- W2156507154 countsByYear W21565071542015 @default.
- W2156507154 countsByYear W21565071542016 @default.
- W2156507154 countsByYear W21565071542017 @default.
- W2156507154 countsByYear W21565071542018 @default.
- W2156507154 countsByYear W21565071542019 @default.
- W2156507154 countsByYear W21565071542020 @default.
- W2156507154 countsByYear W21565071542021 @default.
- W2156507154 countsByYear W21565071542022 @default.
- W2156507154 countsByYear W21565071542023 @default.
- W2156507154 crossrefType "journal-article" @default.
- W2156507154 hasAuthorship W2156507154A5014731366 @default.
- W2156507154 hasAuthorship W2156507154A5048312131 @default.
- W2156507154 hasAuthorship W2156507154A5058554199 @default.
- W2156507154 hasAuthorship W2156507154A5061756250 @default.
- W2156507154 hasAuthorship W2156507154A5075659873 @default.
- W2156507154 hasBestOaLocation W21565071541 @default.
- W2156507154 hasConcept C104317684 @default.
- W2156507154 hasConcept C10858879 @default.
- W2156507154 hasConcept C12554922 @default.
- W2156507154 hasConcept C144647389 @default.
- W2156507154 hasConcept C158617107 @default.
- W2156507154 hasConcept C162740809 @default.