FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156525239> ?p ?o ?g. }

• W2156525239 endingPage "e0142902" @default.
• W2156525239 startingPage "e0142902" @default.
• W2156525239 abstract "Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current study, we show that simvastatin decreased glucose-stimulated insulin secretion in mouse pancreatic MIN6 β-cells by 59% and 79% (p<0.01) at glucose concentration of 5.5 mmol/l and 16.7 mmol/l, respectively, compared to control, whereas pravastatin did not impair insulin secretion. Simvastatin induced decrease in insulin secretion occurred through multiple targets. In addition to its established effects on ATP-sensitive potassium channels (p = 0.004) and voltage-gated calcium channels (p = 0.004), simvastatin suppressed insulin secretion stimulated by muscarinic M3 or GPR40 receptor agonists (Tak875 by 33%, p = 0.002; GW9508 by 77%, p = 0.01) at glucose level of 5.5 mmol/l, and inhibited calcium release from the endoplasmic reticulum. Impaired insulin secretion caused by simvastatin treatment were efficiently restored by GPR119 or GLP-1 receptor stimulation and by direct activation of cAMP-dependent signaling pathways with forskolin. The effects of simvastatin treatment on insulin secretion were not affected by the presence of hyperglycemia. Our observation of the opposite effects of simvastatin and pravastatin on glucose-stimulated insulin secretion is in agreement with previous reports showing that simvastatin, but not pravastatin, was associated with increased risk of incident diabetes." @default.
• W2156525239 created "2016-06-24" @default.
• W2156525239 creator A5007130022 @default.
• W2156525239 creator A5030887232 @default.
• W2156525239 creator A5040473383 @default.
• W2156525239 creator A5051783097 @default.
• W2156525239 creator A5059442267 @default.
• W2156525239 creator A5075407797 @default.
• W2156525239 creator A5078957898 @default.
• W2156525239 date "2015-11-11" @default.
• W2156525239 modified "2023-09-29" @default.
• W2156525239 title "Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells" @default.
• W2156525239 cites W1012070930 @default.
• W2156525239 cites W1530511577 @default.
• W2156525239 cites W1582296909 @default.
• W2156525239 cites W1968498807 @default.
• W2156525239 cites W1969112936 @default.
• W2156525239 cites W1986946948 @default.
• W2156525239 cites W1988196562 @default.
• W2156525239 cites W1993038809 @default.
• W2156525239 cites W2001648811 @default.
• W2156525239 cites W2009672790 @default.
• W2156525239 cites W2015316095 @default.
• W2156525239 cites W2019925176 @default.
• W2156525239 cites W2033526945 @default.
• W2156525239 cites W2033932529 @default.
• W2156525239 cites W2043718702 @default.
• W2156525239 cites W2060476230 @default.
• W2156525239 cites W2065281093 @default.
• W2156525239 cites W2067962261 @default.
• W2156525239 cites W2068858277 @default.
• W2156525239 cites W2077118054 @default.
• W2156525239 cites W2077447504 @default.
• W2156525239 cites W2078668720 @default.
• W2156525239 cites W2089540591 @default.
• W2156525239 cites W2090707240 @default.
• W2156525239 cites W2092933336 @default.
• W2156525239 cites W2094177994 @default.
• W2156525239 cites W2095996114 @default.
• W2156525239 cites W2098789349 @default.
• W2156525239 cites W2103108681 @default.
• W2156525239 cites W2103869501 @default.
• W2156525239 cites W2108628281 @default.
• W2156525239 cites W2113303890 @default.
• W2156525239 cites W2114253024 @default.
• W2156525239 cites W2115169717 @default.
• W2156525239 cites W2128326754 @default.
• W2156525239 cites W2138175677 @default.
• W2156525239 cites W2141063928 @default.
• W2156525239 cites W2151885872 @default.
• W2156525239 cites W2153399820 @default.
• W2156525239 cites W2154718324 @default.
• W2156525239 cites W2156099723 @default.
• W2156525239 cites W2156830026 @default.
• W2156525239 cites W2162348815 @default.
• W2156525239 cites W2163173844 @default.
• W2156525239 cites W2164561590 @default.
• W2156525239 cites W2272687595 @default.
• W2156525239 doi "https://doi.org/10.1371/journal.pone.0142902" @default.
• W2156525239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4641640" @default.
• W2156525239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26561346" @default.
• W2156525239 hasPublicationYear "2015" @default.
• W2156525239 type Work @default.
• W2156525239 sameAs 2156525239 @default.
• W2156525239 citedByCount "37" @default.
• W2156525239 countsByYear W21565252392016 @default.
• W2156525239 countsByYear W21565252392017 @default.
• W2156525239 countsByYear W21565252392018 @default.
• W2156525239 countsByYear W21565252392019 @default.
• W2156525239 countsByYear W21565252392020 @default.
• W2156525239 countsByYear W21565252392021 @default.
• W2156525239 countsByYear W21565252392022 @default.
• W2156525239 countsByYear W21565252392023 @default.
• W2156525239 crossrefType "journal-article" @default.
• W2156525239 hasAuthorship W2156525239A5007130022 @default.
• W2156525239 hasAuthorship W2156525239A5030887232 @default.
• W2156525239 hasAuthorship W2156525239A5040473383 @default.
• W2156525239 hasAuthorship W2156525239A5051783097 @default.
• W2156525239 hasAuthorship W2156525239A5059442267 @default.
• W2156525239 hasAuthorship W2156525239A5075407797 @default.
• W2156525239 hasAuthorship W2156525239A5078957898 @default.
• W2156525239 hasBestOaLocation W21565252391 @default.
• W2156525239 hasConcept C126322002 @default.
• W2156525239 hasConcept C134018914 @default.
• W2156525239 hasConcept C185592680 @default.
• W2156525239 hasConcept C24998067 @default.
• W2156525239 hasConcept C2776329913 @default.
• W2156525239 hasConcept C2776839432 @default.
• W2156525239 hasConcept C2778163477 @default.
• W2156525239 hasConcept C2779276759 @default.
• W2156525239 hasConcept C2779306644 @default.
• W2156525239 hasConcept C2779519902 @default.
• W2156525239 hasConcept C49039625 @default.
• W2156525239 hasConcept C555293320 @default.
• W2156525239 hasConcept C71924100 @default.
• W2156525239 hasConceptScore W2156525239C126322002 @default.
• W2156525239 hasConceptScore W2156525239C134018914 @default.
• W2156525239 hasConceptScore W2156525239C185592680 @default.

• next