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• W2156541443 abstract "Primary cerebral lymphoma (PCL) is defined as nonHodgkin’s lymphoma arising in and and confined to the central nervous system (CNS) [1]. PCL represents less than 2% of extranodal non-Hodgkin’s lymphoma and 0.3%–2.5% of intracranial malignancies [2–4]. The incidence of PCL has increased, paralleling the emergence of human immunodeficiency virus (HIV) infection [5], with a dramatic rise in some western countries such as the USA [6]. PCL is a recognized complication of the acquired immunodeficiency syndrome (AIDS) [7]. The Centers for Disease Control surveillance case definition for AIDS has classified the occurrence of PCL in HIV-infected patients as one of the ‘indicator’ diseases defining the presence of AIDS [8]. The development of AIDS-related PCL (AIDSPCL) often occurs late in the history of AIDS patients [9] and the results of therapy for AIDS-PCL remain unsatisfactory. The role of resection has been disputed [10,11]. Cranial irradiation and steroids remain the conventional treatment and have been used with both palliative and curative intent. For these treated AIDSPCL patients [12–34], the median survival of between 1 and 8 months has been disappointing when compared with the median survival of between 11 and 44 months for PCL in immunocompetent patients without AIDS [1,4,21,35–38]. More recently, chemotherapy has been combined with radiotherapy for the treatment of AIDS-PCL; however, the overall median survival of these patients remains poor. Even the effectiveness of palliation using radiotherapy in AIDS-PCL has been questioned by some investigators [9,23]. The treatment of AIDS-PCL patients has been coloured by their anticipated poor prognosis. As a" @default.
• W2156541443 created "2016-06-24" @default.
• W2156541443 creator A5074507502 @default.
• W2156541443 creator A5082409647 @default.
• W2156541443 date "1999-02-01" @default.
• W2156541443 modified "2023-09-27" @default.
• W2156541443 title "Acquired Immunodeficiency Syndrome-Related Primary Cerebral Lymphoma" @default.
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• W2156541443 doi "https://doi.org/10.1053/clon.1999.9003" @default.
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