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- W2156571387 abstract "Abstract Protoberberine and benzophenanthridine alkaloids were screened for their inhibition of reverse transcriptase activity of RNA tumor viruses in the presence of poly rA. oligo dT, poly dA. oligo dT, poly rC. oligo dG, activated calf thymus DNA and 70S RNA template primers. The comparison of inhibition of reverse transcriptase and antileukemic activities revealed that most of the protoberberine and benzophenanthridine alkaloids tested compared well with their reported antileukemic activities. In general, it was observed that the higher T/C % value resulted in a stronger inhibition of reverse transcriptase activity. The inhibition of nucleic acid polymerases from calf thymus and bacteria and structure-activity relationships are also presented. The alkaloids with the benzophenanthridine ring system were found to display potent inhibition of reverse transcriptase and antileukemic activities." @default.
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- W2156571387 date "1985-01-01" @default.
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- W2156571387 title "Comparison of inhibition of reverse transcriptase and antileukemic activities exhibited by protoberberine and benzophenanthridine alkaloids and structure-activity relationships" @default.
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- W2156571387 doi "https://doi.org/10.1016/s0031-9422(00)80744-x" @default.
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