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- W2156579612 abstract "While attempting to evaluate CD5+ and CD5- anti-DNA-secreting plaque-forming cells (PFC) in patients with systemic lupus erythematosus (SLE), significant numbers of PFC against control sheep erythrocytes (ShE) treated with poly-L-lysine (PLL) but not further conjugated with single-stranded (ss) or double-stranded (ds) DNA were noted. Numbers of PFC obtained using PLL-ShE, ssDNA-ShE and dsDNA-ShE were not significantly different, all reactivity to DNA apparently being accounted for by binding of antibodies to PLL-treated ShE. Nevertheless, anti-PLL-PFC could be inhibited by soluble dsDNA included in the plaque assay. These findings might be explained by cationic anti-DNA antibodies binding non-specifically to anionic PLL. Control healthy subjects gave few PFC against PLL-ShE, ssDNA-ShE or dsDNA-ShE. Anti-PLL-PFC appeared to be related to disease activity, with higher numbers of both CD5+ and CD5- PFC in patients with clinically active SLE." @default.
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- W2156579612 date "1994-01-01" @default.
- W2156579612 modified "2023-10-05" @default.
- W2156579612 title "Cd5-Positive and Cd5-Negative Plaque-Forming Cells Against Poly-L-Lysine-Treated Sheep Erythrocytes in Patients with Systemic Lupus Erythematosus" @default.
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- W2156579612 doi "https://doi.org/10.3109/08916939409007995" @default.
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