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• W2156589968 endingPage "7577" @default.
• W2156589968 startingPage "7567" @default.
• W2156589968 abstract "GLUT4 (glucose transporter 4) plays a pivotal role in insulin-induced glucose uptake to maintain normal blood glucose levels. Here, we report that a cell-permeable phosphoinositide-binding peptide induced GLUT4 translocation to the plasma membrane without inhibiting IRAP (insulin-responsive aminopeptidase) endocytosis. However, unlike insulin treatment, the peptide treatment did not increase glucose uptake in 3T3-L1 adipocytes, indicating that GLUT4 translocation and activation are separate events. GLUT4 activation can occur at the plasma membrane, since insulin was able to increase glucose uptake with a shorter time lag when inactive GLUT4 was first translocated to the plasma membrane by pretreating the cells with this peptide. Inhibition of phosphatidylinositol (PI) 3-kinase activity failed to inhibit GLUT4 translocation by the peptide but did inhibit glucose uptake when insulin was added following peptide treatment. Insulin, but not the peptide, stimulated GLUT1 translocation. Surprisingly, the peptide pretreatment inhibited insulin-induced GLUT1 translocation, suggesting that the peptide treatment has both a stimulatory effect on GLUT4 translocation and an inhibitory effect on insulin-induced GLUT1 translocation. These results suggest that GLUT4 requires translocation to the plasma membrane, as well as activation at the plasma membrane, to initiate glucose uptake, and both of these steps normally require PI 3-kinase activation." @default.
• W2156589968 created "2016-06-24" @default.
• W2156589968 creator A5028268542 @default.
• W2156589968 creator A5041321873 @default.
• W2156589968 creator A5066087614 @default.
• W2156589968 date "2004-09-01" @default.
• W2156589968 modified "2023-09-26" @default.
• W2156589968 title "Separation of Insulin Signaling into Distinct GLUT4 Translocation and Activation Steps" @default.
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• W2156589968 doi "https://doi.org/10.1128/mcb.24.17.7567-7577.2004" @default.
• W2156589968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/507006" @default.
• W2156589968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15314166" @default.
• W2156589968 hasPublicationYear "2004" @default.
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• W2156589968 hasAuthorship W2156589968A5066087614 @default.

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