FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156598346> ?p ?o ?g. }

• W2156598346 endingPage "13" @default.
• W2156598346 startingPage "1" @default.
• W2156598346 abstract "The immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains associated with the T cell receptor (TCR) are crucial for TCR signaling. To probe the role of the CD3gamma-ITAM in T cell development, we created knock-in mice in which the CD3gamma chain of the TCR complex is replaced by a mutant signaling-deficient CD3gamma chain, lacking the CD3gamma-ITAM. This mutation results in considerable impairment in positive selection in the polyclonal TCR repertoire. When CD3gamma-deltaITAM mice are crossed to mice expressing transgenic F5 TCRs, their thymocytes are completely unable to perform positive selection in vivo in response to intrathymic ligands. Also, the in vitro positive selection response of double-positive (DP) thymocytes with F5-CD3gamma-deltaITAM mutant receptors to their agonist ligand and many of its variants is severely impaired or abrogated. Yet, the binding and dissociation constants of agonist ligands for the F5 receptor are not affected by the CD3gamma-deltaITAM mutation. Furthermore, DP thymocytes with mutant receptors can respond to agonist ligand with normal antigen sensitivity and to normal levels, as shown by their ability to induce CD69 up-regulation, TCR down-regulation, negative selection, and ZAP70 and c-Jun NH2-terminal kinase activation. In sharp contrast, induction of extracellular signal-regulated kinase (ERK) activation and linker for activation of T cells (LAT) phosphorylation are severely impaired in these cells. Together, these findings underscore that intrinsic properties of the TCR-CD3 complex regulate selection at the DP checkpoint. More importantly, this analysis provides the first direct genetic evidence for a role of the CD3gamma-ITAM in TCR-driven thymocyte selection." @default.
• W2156598346 created "2016-06-24" @default.
• W2156598346 creator A5003429202 @default.
• W2156598346 creator A5005069677 @default.
• W2156598346 creator A5009363849 @default.
• W2156598346 creator A5024522246 @default.
• W2156598346 creator A5028481161 @default.
• W2156598346 creator A5038807612 @default.
• W2156598346 creator A5050791246 @default.
• W2156598346 creator A5091439544 @default.
• W2156598346 date "2002-06-24" @default.
• W2156598346 modified "2023-10-14" @default.
• W2156598346 title "Contributions of the T Cell Receptor–associated CD3γ–ITAM to Thymocyte Selection" @default.
• W2156598346 cites W1525267854 @default.
• W2156598346 cites W1544291870 @default.
• W2156598346 cites W1545434216 @default.
• W2156598346 cites W1586171131 @default.
• W2156598346 cites W1598201397 @default.
• W2156598346 cites W1618519163 @default.
• W2156598346 cites W1804861156 @default.
• W2156598346 cites W18630108 @default.
• W2156598346 cites W1954954383 @default.
• W2156598346 cites W1965157379 @default.
• W2156598346 cites W1967400782 @default.
• W2156598346 cites W1969958391 @default.
• W2156598346 cites W1975087118 @default.
• W2156598346 cites W1981375452 @default.
• W2156598346 cites W1982373973 @default.
• W2156598346 cites W1982726239 @default.
• W2156598346 cites W1995205975 @default.
• W2156598346 cites W1998730889 @default.
• W2156598346 cites W2001467625 @default.
• W2156598346 cites W2004668797 @default.
• W2156598346 cites W2005274005 @default.
• W2156598346 cites W2009335336 @default.
• W2156598346 cites W2009907090 @default.
• W2156598346 cites W2023601085 @default.
• W2156598346 cites W2028752761 @default.
• W2156598346 cites W2030668414 @default.
• W2156598346 cites W2035820068 @default.
• W2156598346 cites W2038173050 @default.
• W2156598346 cites W2048075567 @default.
• W2156598346 cites W2048359961 @default.
• W2156598346 cites W2058441584 @default.
• W2156598346 cites W2058588605 @default.
• W2156598346 cites W2062999278 @default.
• W2156598346 cites W2063197602 @default.
• W2156598346 cites W2076674503 @default.
• W2156598346 cites W2077648546 @default.
• W2156598346 cites W2087008658 @default.
• W2156598346 cites W2095745067 @default.
• W2156598346 cites W2114293083 @default.
• W2156598346 cites W2117343132 @default.
• W2156598346 cites W2123717669 @default.
• W2156598346 cites W2131894799 @default.
• W2156598346 cites W2135760279 @default.
• W2156598346 cites W2146573379 @default.
• W2156598346 cites W2147055245 @default.
• W2156598346 cites W2148562724 @default.
• W2156598346 cites W2151151593 @default.
• W2156598346 cites W2153032235 @default.
• W2156598346 cites W2164682544 @default.
• W2156598346 cites W2166864620 @default.
• W2156598346 cites W2168728330 @default.
• W2156598346 cites W4313379447 @default.
• W2156598346 cites W95054676 @default.
• W2156598346 doi "https://doi.org/10.1084/jem.20020268" @default.
• W2156598346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2194018" @default.
• W2156598346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12093866" @default.
• W2156598346 hasPublicationYear "2002" @default.
• W2156598346 type Work @default.
• W2156598346 sameAs 2156598346 @default.
• W2156598346 citedByCount "33" @default.
• W2156598346 countsByYear W21565983462013 @default.
• W2156598346 countsByYear W21565983462017 @default.
• W2156598346 countsByYear W21565983462018 @default.
• W2156598346 countsByYear W21565983462019 @default.
• W2156598346 countsByYear W21565983462021 @default.
• W2156598346 countsByYear W21565983462022 @default.
• W2156598346 crossrefType "journal-article" @default.
• W2156598346 hasAuthorship W2156598346A5003429202 @default.
• W2156598346 hasAuthorship W2156598346A5005069677 @default.
• W2156598346 hasAuthorship W2156598346A5009363849 @default.
• W2156598346 hasAuthorship W2156598346A5024522246 @default.
• W2156598346 hasAuthorship W2156598346A5028481161 @default.
• W2156598346 hasAuthorship W2156598346A5038807612 @default.
• W2156598346 hasAuthorship W2156598346A5050791246 @default.
• W2156598346 hasAuthorship W2156598346A5091439544 @default.
• W2156598346 hasBestOaLocation W21565983461 @default.
• W2156598346 hasConcept C104317684 @default.
• W2156598346 hasConcept C114684123 @default.
• W2156598346 hasConcept C120642132 @default.
• W2156598346 hasConcept C141231307 @default.
• W2156598346 hasConcept C147483822 @default.
• W2156598346 hasConcept C153911025 @default.
• W2156598346 hasConcept C167672396 @default.
• W2156598346 hasConcept C170493617 @default.
• W2156598346 hasConcept C19317047 @default.

• next