FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156657712> ?p ?o ?g. }

• W2156657712 endingPage "1099" @default.
• W2156657712 startingPage "1087" @default.
• W2156657712 abstract "The Hippo pathway is a key signaling cascade in controlling organ size. The core components of this pathway are two kinases, Hippo (Hpo) and Warts (Wts), and a transcriptional coactivator, Yorkie (Yki). Yes-associated protein (YAP, a Yki homolog in mammals) promotes epithelial-mesenchymal transition and cell migration in vitro. Here, we use border cells in the Drosophila ovary as a model to study Hippo pathway functions in cell migration in vivo. During oogenesis, polar cells secrete Unpaired (Upd), which activates JAK/STAT signaling of neighboring cells and specifies them into outer border cells. The outer border cells form a cluster with polar cells and undergo migration. We find that hpo and wts are required for migration of the border cell cluster. In outer border cells, overexpression of hpo disrupts polarization of the actin cytoskeleton and attenuates migration. In polar cells, knockdown of hpo and wts or overexpression of yki impairs border cell induction and disrupts migration. These manipulations in polar cells reduce JAK/STAT activity in outer border cells. Expression of upd-lacZ is increased and decreased in yki and hpo mutant polar cells, respectively. Furthermore, forced expression of upd in polar cells rescues defects of border cell induction and migration caused by wts knockdown. These results suggest that Yki negatively regulates border cell induction by inhibiting JAK/STAT signaling. Together, our data elucidate two distinct mechanisms of the Hippo pathway in controlling border cell migration: (1) in outer border cells, it regulates polarized distribution of the actin cytoskeleton; (2) in polar cells, it regulates upd expression to control border cell induction and migration." @default.
• W2156657712 created "2016-06-24" @default.
• W2156657712 creator A5040928689 @default.
• W2156657712 creator A5066655506 @default.
• W2156657712 creator A5071129313 @default.
• W2156657712 creator A5079129261 @default.
• W2156657712 date "2014-08-26" @default.
• W2156657712 modified "2023-10-18" @default.
• W2156657712 title "The Hippo Pathway Controls Border Cell Migration Through Distinct Mechanisms in Outer Border Cells and Polar Cells of the <i>Drosophila</i> Ovary" @default.
• W2156657712 cites W1567765448 @default.
• W2156657712 cites W1782202106 @default.
• W2156657712 cites W1964081206 @default.
• W2156657712 cites W1964491152 @default.
• W2156657712 cites W1965066532 @default.
• W2156657712 cites W1968650783 @default.
• W2156657712 cites W1968814136 @default.
• W2156657712 cites W1969837969 @default.
• W2156657712 cites W1974673111 @default.
• W2156657712 cites W1975971309 @default.
• W2156657712 cites W1976425040 @default.
• W2156657712 cites W1978746441 @default.
• W2156657712 cites W1979351753 @default.
• W2156657712 cites W1983096415 @default.
• W2156657712 cites W1984282087 @default.
• W2156657712 cites W1984350114 @default.
• W2156657712 cites W1984488853 @default.
• W2156657712 cites W1985034953 @default.
• W2156657712 cites W1985972808 @default.
• W2156657712 cites W1987328891 @default.
• W2156657712 cites W1988549596 @default.
• W2156657712 cites W1989899025 @default.
• W2156657712 cites W1996420367 @default.
• W2156657712 cites W1998481526 @default.
• W2156657712 cites W1998563859 @default.
• W2156657712 cites W1999751317 @default.
• W2156657712 cites W2000269194 @default.
• W2156657712 cites W2002116477 @default.
• W2156657712 cites W2003111150 @default.
• W2156657712 cites W2006778392 @default.
• W2156657712 cites W2008223819 @default.
• W2156657712 cites W2010675523 @default.
• W2156657712 cites W2011121500 @default.
• W2156657712 cites W2018780447 @default.
• W2156657712 cites W2023267153 @default.
• W2156657712 cites W2023471348 @default.
• W2156657712 cites W2028088511 @default.
• W2156657712 cites W2028776361 @default.
• W2156657712 cites W2029856261 @default.
• W2156657712 cites W2029985957 @default.
• W2156657712 cites W2033500225 @default.
• W2156657712 cites W2034469841 @default.
• W2156657712 cites W2034751657 @default.
• W2156657712 cites W2037153689 @default.
• W2156657712 cites W2037598426 @default.
• W2156657712 cites W2038240599 @default.
• W2156657712 cites W2046985565 @default.
• W2156657712 cites W2047368505 @default.
• W2156657712 cites W2047531031 @default.
• W2156657712 cites W2050712486 @default.
• W2156657712 cites W2057708838 @default.
• W2156657712 cites W2059576320 @default.
• W2156657712 cites W2073568903 @default.
• W2156657712 cites W2074184810 @default.
• W2156657712 cites W2075932391 @default.
• W2156657712 cites W2078339435 @default.
• W2156657712 cites W2079259838 @default.
• W2156657712 cites W2081092282 @default.
• W2156657712 cites W2083106714 @default.
• W2156657712 cites W2083121410 @default.
• W2156657712 cites W2084047401 @default.
• W2156657712 cites W2085197940 @default.
• W2156657712 cites W2085250524 @default.
• W2156657712 cites W2087575288 @default.
• W2156657712 cites W2089731187 @default.
• W2156657712 cites W2090478056 @default.
• W2156657712 cites W2091621334 @default.
• W2156657712 cites W2091883691 @default.
• W2156657712 cites W2092128105 @default.
• W2156657712 cites W2093392157 @default.
• W2156657712 cites W2095065858 @default.
• W2156657712 cites W2097276658 @default.
• W2156657712 cites W2099072529 @default.
• W2156657712 cites W2100739474 @default.
• W2156657712 cites W2118671972 @default.
• W2156657712 cites W2125327183 @default.
• W2156657712 cites W2132605861 @default.
• W2156657712 cites W2141595533 @default.
• W2156657712 cites W2143076230 @default.
• W2156657712 cites W2147926680 @default.
• W2156657712 cites W2148745843 @default.
• W2156657712 cites W2159935247 @default.
• W2156657712 cites W2160300536 @default.
• W2156657712 cites W2160572702 @default.
• W2156657712 cites W2166315274 @default.
• W2156657712 cites W2167978765 @default.
• W2156657712 cites W2168047241 @default.
• W2156657712 doi "https://doi.org/10.1534/genetics.114.167346" @default.
• W2156657712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4224154" @default.

• next