FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156673956> ?p ?o ?g. }

• W2156673956 endingPage "7109" @default.
• W2156673956 startingPage "7096" @default.
• W2156673956 abstract "Kinetoplastid RNA (kRNA) editing is a process that creates translatable mitochondrial mRNA transcripts from cryptogene encoded RNAs and is unique for kinetoplastids, such as Trypanosoma brucei. In addition to the catalytic 20S editosome, multiple accessory proteins are required for this conversion. Recently, the multiprotein mitochondrial RNA binding complex 1 (MRB1) has emerged as a key player in this process. MRB1 consists of six core proteins but makes dynamic interactions with additional accessory proteins. Here we describe the characterization of one such factor, the 72 kDa MRB1590 protein. In vivo experiments indicate a role for MRB1590 in editing mitochondrial mRNA transcripts, in particular the transcript encoding the ATP synthase subunit 6 (A6). Structural studies show that MRB1590 is dimeric and contains a central ABC-ATPase fold embedded between novel N- and C-terminal regions. The N-terminal domains combine to create a basic pore and biochemical studies indicate residues in this region participate in RNA binding. Structures capturing distinct MRB1590 conformations reveal that the RNA binding pore adopts closed and open states, with the latter able to accommodate RNA. Based on these findings, implications for MRB1590 function are discussed." @default.
• W2156673956 created "2016-06-24" @default.
• W2156673956 creator A5022667027 @default.
• W2156673956 creator A5030740360 @default.
• W2156673956 creator A5039844553 @default.
• W2156673956 creator A5058340687 @default.
• W2156673956 creator A5060132420 @default.
• W2156673956 creator A5081072747 @default.
• W2156673956 date "2015-06-27" @default.
• W2156673956 modified "2023-09-27" @default.
• W2156673956 title "Structures of the<i>T. brucei</i>kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold" @default.
• W2156673956 cites W1484664508 @default.
• W2156673956 cites W1508587432 @default.
• W2156673956 cites W1539796472 @default.
• W2156673956 cites W1587183889 @default.
• W2156673956 cites W1971247694 @default.
• W2156673956 cites W1981871034 @default.
• W2156673956 cites W1992773757 @default.
• W2156673956 cites W1992864884 @default.
• W2156673956 cites W1994772523 @default.
• W2156673956 cites W1994855421 @default.
• W2156673956 cites W2006563536 @default.
• W2156673956 cites W2030521870 @default.
• W2156673956 cites W2032133188 @default.
• W2156673956 cites W2035503835 @default.
• W2156673956 cites W2036842869 @default.
• W2156673956 cites W2039771729 @default.
• W2156673956 cites W2051075703 @default.
• W2156673956 cites W2052004935 @default.
• W2156673956 cites W2062885653 @default.
• W2156673956 cites W2072717059 @default.
• W2156673956 cites W2080653091 @default.
• W2156673956 cites W2085444198 @default.
• W2156673956 cites W2087344117 @default.
• W2156673956 cites W2087744052 @default.
• W2156673956 cites W2088834030 @default.
• W2156673956 cites W2091577013 @default.
• W2156673956 cites W2096993626 @default.
• W2156673956 cites W2100118637 @default.
• W2156673956 cites W2100969185 @default.
• W2156673956 cites W2101147288 @default.
• W2156673956 cites W2101926477 @default.
• W2156673956 cites W2121053020 @default.
• W2156673956 cites W2122232422 @default.
• W2156673956 cites W2124026197 @default.
• W2156673956 cites W2126114647 @default.
• W2156673956 cites W2141157874 @default.
• W2156673956 cites W2142128688 @default.
• W2156673956 cites W2142528445 @default.
• W2156673956 cites W2144929331 @default.
• W2156673956 cites W2146733597 @default.
• W2156673956 cites W2150265408 @default.
• W2156673956 cites W2160475848 @default.
• W2156673956 cites W2160942775 @default.
• W2156673956 cites W2161907726 @default.
• W2156673956 cites W2164191222 @default.
• W2156673956 cites W2165560454 @default.
• W2156673956 cites W2168881521 @default.
• W2156673956 cites W2169821755 @default.
• W2156673956 cites W2170082865 @default.
• W2156673956 cites W2171514321 @default.
• W2156673956 cites W2171895257 @default.
• W2156673956 cites W2180229411 @default.
• W2156673956 cites W2321082745 @default.
• W2156673956 cites W4235823073 @default.
• W2156673956 cites W69814808 @default.
• W2156673956 doi "https://doi.org/10.1093/nar/gkv647" @default.
• W2156673956 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4538832" @default.
• W2156673956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26117548" @default.
• W2156673956 hasPublicationYear "2015" @default.
• W2156673956 type Work @default.
• W2156673956 sameAs 2156673956 @default.
• W2156673956 citedByCount "12" @default.
• W2156673956 countsByYear W21566739562015 @default.
• W2156673956 countsByYear W21566739562016 @default.
• W2156673956 countsByYear W21566739562018 @default.
• W2156673956 countsByYear W21566739562019 @default.
• W2156673956 countsByYear W21566739562020 @default.
• W2156673956 countsByYear W21566739562021 @default.
• W2156673956 countsByYear W21566739562023 @default.
• W2156673956 crossrefType "journal-article" @default.
• W2156673956 hasAuthorship W2156673956A5022667027 @default.
• W2156673956 hasAuthorship W2156673956A5030740360 @default.
• W2156673956 hasAuthorship W2156673956A5039844553 @default.
• W2156673956 hasAuthorship W2156673956A5058340687 @default.
• W2156673956 hasAuthorship W2156673956A5060132420 @default.
• W2156673956 hasAuthorship W2156673956A5081072747 @default.
• W2156673956 hasBestOaLocation W21566739561 @default.
• W2156673956 hasConcept C100299639 @default.
• W2156673956 hasConcept C104292427 @default.
• W2156673956 hasConcept C104317684 @default.
• W2156673956 hasConcept C105580179 @default.
• W2156673956 hasConcept C141231307 @default.
• W2156673956 hasConcept C144501496 @default.
• W2156673956 hasConcept C153911025 @default.
• W2156673956 hasConcept C194993378 @default.
• W2156673956 hasConcept C21786251 @default.
• W2156673956 hasConcept C2779502636 @default.

• next