FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156681425> ?p ?o ?g. }

• W2156681425 endingPage "170" @default.
• W2156681425 startingPage "157" @default.
• W2156681425 abstract "An important step in megakaryocyte maturation is the appropriate assembly of at least two distinct subsets of α-granules. The mechanism that sorts the α-granule components into distinct structures and mediates their release in response to specific stimuli is now emerging. P-selectin and von Willebrand factor are two proteins present in the α-granules that recognize P-selectin glycoprotein ligand on neutrophils and collagen in the subendothelial matrix. These proteins may play an important role in determining the differential release of the α-granule contents in response to external stimuli. If P-selectin and von Willebrand factor are localized in the same or different α-granules is not known. To clarify this question, we analyzed by immunoelectron microscopy the localization of von Willebrand factor and P-selectin during the maturation of wild-type and Gata1low megakaryocytes induced in vivo by treating animals with thrombopoietin. Gata1low is a hypomorphic mutation that blocks megakaryocyte maturation, reduces the levels of von Willebrand factor expression and displaces P-selectin on the demarcation membrane system. The maturation block induced by this mutation is partially rescued by treatment in vivo with thrombopoietin. In immature megakaryocytes, both wild-type and Gata1low, the two receptors were co-localized in the same cytoplasmic structures. By contrast, the two proteins were segregated to separate α-granule subsets as the megakaryocytes matured. These observations support the hypothesis that P-selectin and von Willebrand factor may ensure differential release of the α-granule content in response to external stimuli." @default.
• W2156681425 created "2016-06-24" @default.
• W2156681425 creator A5007415246 @default.
• W2156681425 creator A5011897595 @default.
• W2156681425 creator A5046314965 @default.
• W2156681425 creator A5053717024 @default.
• W2156681425 creator A5060907157 @default.
• W2156681425 creator A5062235390 @default.
• W2156681425 creator A5072277062 @default.
• W2156681425 date "2010-01-01" @default.
• W2156681425 modified "2023-09-27" @default.
• W2156681425 title "Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation" @default.
• W2156681425 cites W112534252 @default.
• W2156681425 cites W1501307196 @default.
• W2156681425 cites W1585437324 @default.
• W2156681425 cites W189385581 @default.
• W2156681425 cites W1970890131 @default.
• W2156681425 cites W1983631422 @default.
• W2156681425 cites W1983760732 @default.
• W2156681425 cites W1995229467 @default.
• W2156681425 cites W1995601334 @default.
• W2156681425 cites W2001189096 @default.
• W2156681425 cites W2006545438 @default.
• W2156681425 cites W2019874022 @default.
• W2156681425 cites W2038818733 @default.
• W2156681425 cites W2080324043 @default.
• W2156681425 cites W2086646375 @default.
• W2156681425 cites W2104025073 @default.
• W2156681425 cites W2104680298 @default.
• W2156681425 cites W2105810068 @default.
• W2156681425 cites W2109042362 @default.
• W2156681425 cites W2122082665 @default.
• W2156681425 cites W2154848828 @default.
• W2156681425 cites W2156495603 @default.
• W2156681425 cites W2157988767 @default.
• W2156681425 cites W2210931878 @default.
• W2156681425 cites W226237940 @default.
• W2156681425 cites W2413533040 @default.
• W2156681425 cites W257391547 @default.
• W2156681425 cites W41707389 @default.
• W2156681425 cites W4241182814 @default.
• W2156681425 doi "https://doi.org/10.3109/10520290903149612" @default.
• W2156681425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3700322" @default.
• W2156681425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20426698" @default.
• W2156681425 hasPublicationYear "2010" @default.
• W2156681425 type Work @default.
• W2156681425 sameAs 2156681425 @default.
• W2156681425 citedByCount "9" @default.
• W2156681425 countsByYear W21566814252013 @default.
• W2156681425 countsByYear W21566814252015 @default.
• W2156681425 countsByYear W21566814252017 @default.
• W2156681425 countsByYear W21566814252018 @default.
• W2156681425 countsByYear W21566814252022 @default.
• W2156681425 crossrefType "journal-article" @default.
• W2156681425 hasAuthorship W2156681425A5007415246 @default.
• W2156681425 hasAuthorship W2156681425A5011897595 @default.
• W2156681425 hasAuthorship W2156681425A5046314965 @default.
• W2156681425 hasAuthorship W2156681425A5053717024 @default.
• W2156681425 hasAuthorship W2156681425A5060907157 @default.
• W2156681425 hasAuthorship W2156681425A5062235390 @default.
• W2156681425 hasAuthorship W2156681425A5072277062 @default.
• W2156681425 hasBestOaLocation W21566814252 @default.
• W2156681425 hasConcept C109159458 @default.
• W2156681425 hasConcept C151730666 @default.
• W2156681425 hasConcept C153911025 @default.
• W2156681425 hasConcept C159654299 @default.
• W2156681425 hasConcept C185592680 @default.
• W2156681425 hasConcept C203014093 @default.
• W2156681425 hasConcept C2777863708 @default.
• W2156681425 hasConcept C2779394231 @default.
• W2156681425 hasConcept C2779705218 @default.
• W2156681425 hasConcept C28328180 @default.
• W2156681425 hasConcept C2993140218 @default.
• W2156681425 hasConcept C3018697912 @default.
• W2156681425 hasConcept C49760210 @default.
• W2156681425 hasConcept C56701166 @default.
• W2156681425 hasConcept C86803240 @default.
• W2156681425 hasConcept C89560881 @default.
• W2156681425 hasConcept C95444343 @default.
• W2156681425 hasConceptScore W2156681425C109159458 @default.
• W2156681425 hasConceptScore W2156681425C151730666 @default.
• W2156681425 hasConceptScore W2156681425C153911025 @default.
• W2156681425 hasConceptScore W2156681425C159654299 @default.
• W2156681425 hasConceptScore W2156681425C185592680 @default.
• W2156681425 hasConceptScore W2156681425C203014093 @default.
• W2156681425 hasConceptScore W2156681425C2777863708 @default.
• W2156681425 hasConceptScore W2156681425C2779394231 @default.
• W2156681425 hasConceptScore W2156681425C2779705218 @default.
• W2156681425 hasConceptScore W2156681425C28328180 @default.
• W2156681425 hasConceptScore W2156681425C2993140218 @default.
• W2156681425 hasConceptScore W2156681425C3018697912 @default.
• W2156681425 hasConceptScore W2156681425C49760210 @default.
• W2156681425 hasConceptScore W2156681425C56701166 @default.
• W2156681425 hasConceptScore W2156681425C86803240 @default.
• W2156681425 hasConceptScore W2156681425C89560881 @default.
• W2156681425 hasConceptScore W2156681425C95444343 @default.
• W2156681425 hasIssue "3" @default.
• W2156681425 hasLocation W21566814251 @default.

• next