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• W2156739085 abstract "Background: An association between use of zidovudine and didanosine and a rare but life-threatening syndrome of hepatic steatosis, lactic acidosis, and myopathy has been reported. Objective: To describe the syndrome of hepatic steatosis, lactic acidosis, and myopathy in four patients taking stavudine. Design: Case series. Setting: A community hospital in Washington, D.C., and National Institutes of Health Clinical Center, Bethesda, Maryland. Patients: Two men and two women with HIV-1 infection who were taking stavudine presented with lactic acidosis and elevated levels of aminotransferases. All patients required intensive care. Measurements: Levels of lactic acid, alanine aminotransferase, aspartate aminotransferase, amylase, and lipase; computed tomography of the abdomen; liver biopsy (two patients); and muscle biopsy (two patients). Results: Histologic findings consistent with mitochondrial injury confirmed the diagnosis of hepatic or muscle abnormality. Conclusion: Because hepatic steatosis may be life-threatening, physicians should consider it as a possible cause of elevated hepatic aminotransferase levels among patients taking stavudine." @default.
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• W2156739085 date "2000-08-01" @default.
• W2156739085 modified "2023-10-16" @default.
• W2156739085 title "Lactic Acidosis and Hepatic Steatosis Associated with Use of Stavudine: Report of Four Cases" @default.
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• W2156739085 doi "https://doi.org/10.7326/0003-4819-133-3-200008010-00010" @default.
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