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- W2156742440 abstract "Hirsch R, Deng H, Laohachai MN. Azithromycin in periodontal treatment: more than an antibiotic. J Periodont Res 2012; 47: 137–148. © 2011 John Wiley & Sons A/S Azithromycin is a macrolide antibiotic used extensively in medicine for the treatment of a wide range of infections such as upper respiratory tract infections, middle ear infections, sexually transmitted infections and trachoma. It is also effective against the most common periodontopathogens. The versatility of the macrolides extends beyond their antibiotic properties as a result of their well-documented immune-modulating/anti-inflammatory effects. Macrolides, including azithromycin, are therefore used to treat diseases not associated with bacteria, such as severe asthma, chronic obstructive pulmonary diseases and, more recently, cystic fibrosis. Azithromycin is concentrated in neutrophils, macrophages and particularly fibroblasts; all of these cells are central players in the pathogenesis of most periodontal diseases. This paper reviews the diverse properties of azithromycin and the clinical periodontal studies of its effects in both the treatment of periodontitis and in resolving drug-related gingival overgrowth. Evidence exists to support the use of a single course of azithromycin in the treatment of advanced periodontal diseases. Azithromycin could have a triple role in the treatment and resolution of periodontal diseases: suppressing periodontopathogens, anti-inflammatory activity and healing through persistence at low levels in macrophages and fibroblasts in periodontal tissues, even after a single course of three tablets. If future periodontal research confirms these properties, it could become a valuable host-modulator in periodontal treatment." @default.
- W2156742440 created "2016-06-24" @default.
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- W2156742440 date "2011-11-04" @default.
- W2156742440 modified "2023-09-27" @default.
- W2156742440 title "Azithromycin in periodontal treatment: more than an antibiotic" @default.
- W2156742440 cites W126695153 @default.
- W2156742440 cites W1858894787 @default.
- W2156742440 cites W1949233923 @default.
- W2156742440 cites W1967101096 @default.
- W2156742440 cites W1967342327 @default.
- W2156742440 cites W1967389480 @default.
- W2156742440 cites W1967848728 @default.
- W2156742440 cites W1970762858 @default.
- W2156742440 cites W1977047743 @default.
- W2156742440 cites W1979160489 @default.
- W2156742440 cites W1979286787 @default.
- W2156742440 cites W1979944002 @default.
- W2156742440 cites W1980126263 @default.
- W2156742440 cites W1982518012 @default.
- W2156742440 cites W1991639866 @default.
- W2156742440 cites W1991805767 @default.
- W2156742440 cites W1993572702 @default.
- W2156742440 cites W2000344153 @default.
- W2156742440 cites W2001769115 @default.
- W2156742440 cites W2005334405 @default.
- W2156742440 cites W2005817152 @default.
- W2156742440 cites W2006148788 @default.
- W2156742440 cites W2024690313 @default.
- W2156742440 cites W2029923764 @default.
- W2156742440 cites W2030055167 @default.
- W2156742440 cites W2036657744 @default.
- W2156742440 cites W2040886425 @default.
- W2156742440 cites W2047758711 @default.
- W2156742440 cites W2049784078 @default.
- W2156742440 cites W2053014384 @default.
- W2156742440 cites W2053066743 @default.
- W2156742440 cites W2055073344 @default.
- W2156742440 cites W2058137202 @default.
- W2156742440 cites W2058977870 @default.
- W2156742440 cites W2066458167 @default.
- W2156742440 cites W2069975147 @default.
- W2156742440 cites W2071107349 @default.
- W2156742440 cites W2076941276 @default.
- W2156742440 cites W2081524758 @default.
- W2156742440 cites W2083409602 @default.
- W2156742440 cites W2088017501 @default.
- W2156742440 cites W2093337868 @default.
- W2156742440 cites W2096099936 @default.
- W2156742440 cites W2097553001 @default.
- W2156742440 cites W2099151165 @default.
- W2156742440 cites W2100849338 @default.
- W2156742440 cites W2101221272 @default.
- W2156742440 cites W2104853888 @default.
- W2156742440 cites W2106986282 @default.
- W2156742440 cites W2109736767 @default.
- W2156742440 cites W2111033886 @default.
- W2156742440 cites W2111992180 @default.
- W2156742440 cites W2113452209 @default.
- W2156742440 cites W2113882007 @default.
- W2156742440 cites W2116202147 @default.
- W2156742440 cites W2119396878 @default.
- W2156742440 cites W2119441508 @default.
- W2156742440 cites W2123000331 @default.
- W2156742440 cites W2123178771 @default.
- W2156742440 cites W2129265198 @default.
- W2156742440 cites W2133085705 @default.
- W2156742440 cites W2136960553 @default.
- W2156742440 cites W2137617675 @default.
- W2156742440 cites W2138491957 @default.
- W2156742440 cites W2138904885 @default.
- W2156742440 cites W2140926100 @default.
- W2156742440 cites W2144056311 @default.
- W2156742440 cites W2145891230 @default.
- W2156742440 cites W2146569193 @default.
- W2156742440 cites W2149579818 @default.
- W2156742440 cites W2149685466 @default.
- W2156742440 cites W2157133445 @default.
- W2156742440 cites W2158649901 @default.
- W2156742440 cites W2158685725 @default.
- W2156742440 cites W2159252023 @default.
- W2156742440 cites W2160083296 @default.
- W2156742440 cites W2160142630 @default.
- W2156742440 cites W2161306971 @default.
- W2156742440 cites W2165829657 @default.
- W2156742440 cites W2168853424 @default.
- W2156742440 cites W2316640143 @default.
- W2156742440 cites W2328728350 @default.
- W2156742440 cites W4246928517 @default.
- W2156742440 cites W4375905966 @default.
- W2156742440 doi "https://doi.org/10.1111/j.1600-0765.2011.01418.x" @default.
- W2156742440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22050485" @default.
- W2156742440 hasPublicationYear "2011" @default.
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