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• W2156768991 abstract "ABSTRACT CC chemokine receptor 4 (CCR4) and its two ligands, CCL17 and CCL22, are critically involved in different immune processes. In models of lipopolysaccharide-induced shock, CCR4-deficient (CCR4 −/− ) mice showed improved survival rates associated with attenuated proinflammatory cytokine release. Using CCR4 −/− mice with a C57BL/6 background, this study describes for the first time the role of CCR4 in a murine model of polymicrobial abdominal sepsis, the colon ascendens stent peritonitis (CASP). CASP-induced sepsis led to a massive downregulation of CCR4 in lymphoid and nonlymphoid tissues, whereas the expression of CCL17 and CCL22 was independent of the presence of CCR4. After CASP, CCR4 −/− animals showed a strongly enhanced bacterial clearance in several organs but not in the peritoneal lavage fluid and the blood. In addition, significantly reduced levels of proinflammatory cytokines/chemokines were measured in organ supernatants as well as in the sera of CCR4 −/− mice. CCR4 deficiency consequently resulted in an attenuated severity of systemic sepsis and a strongly improved survival rate after CASP or CASP with intervention. Thus, our data provide clear evidence that CCR4 plays a strictly detrimental role in the course of polymicrobial sepsis." @default.
• W2156768991 created "2016-06-24" @default.
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• W2156768991 date "2008-11-01" @default.
• W2156768991 modified "2023-09-23" @default.
• W2156768991 title "Detrimental Role of CC Chemokine Receptor 4 in Murine Polymicrobial Sepsis" @default.
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• W2156768991 doi "https://doi.org/10.1128/iai.00310-08" @default.
• W2156768991 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2573314" @default.
• W2156768991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18765730" @default.
• W2156768991 hasPublicationYear "2008" @default.
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