Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156792116> ?p ?o ?g. }
- W2156792116 endingPage "13531" @default.
- W2156792116 startingPage "13526" @default.
- W2156792116 abstract "The first fully synthetic glycopeptide vaccines against a fungal disease have been used to combat disseminated candidiasis in mice. Six T cell peptides found in Candida albicans cell wall proteins were selected by algorithm peptide epitope searches; each was synthesized and conjugated to the fungal cell wall beta-mannan trisaccharide [beta-(Man)(3)] by novel saccharide-peptide linker chemistry to create glycopeptide conjugates. The six proteins were selected because of expression during human candidiasis and cell wall association and included: fructose-bisphosphate aldolase (Fba); methyltetrahydropteroyltriglutamate (Met6); hyphal wall protein-1 (Hwp1); enolase (Enol); glyceraldehyde-3-phosphate dehydrogenase (Gap1); and phosphoglycerate kinase (Pgk1). By immunization protocols favoring production of protective antibody, the beta-(Man)(3)-Fba, beta-(Man)(3)-Met6 and beta-(Man)(3)-Hwp1 induced protection evidenced by survival and reduced kidney fungal burden, the beta-(Man)(3)-Eno1 and beta-(Man)(3)-Gap1 gave moderate protection, and the beta-(Man)(3)-Pgk1 slightly enhanced disease. For the beta-(Man)(3)-Fba conjugate, protection was uniquely acquired through immunity against the carbohydrate and the Fba peptide. This approach based on fully synthetic chemically defined immunogens should be generally useful in vaccine development." @default.
- W2156792116 created "2016-06-24" @default.
- W2156792116 creator A5009197907 @default.
- W2156792116 creator A5027177608 @default.
- W2156792116 creator A5073005007 @default.
- W2156792116 creator A5078747529 @default.
- W2156792116 date "2008-09-09" @default.
- W2156792116 modified "2023-10-18" @default.
- W2156792116 title "Synthetic glycopeptide vaccines combining β-mannan and peptide epitopes induce protection against candidiasis" @default.
- W2156792116 cites W1593193715 @default.
- W2156792116 cites W1603690031 @default.
- W2156792116 cites W1734385177 @default.
- W2156792116 cites W1968155668 @default.
- W2156792116 cites W1969718949 @default.
- W2156792116 cites W1973136622 @default.
- W2156792116 cites W1981400664 @default.
- W2156792116 cites W1991052155 @default.
- W2156792116 cites W1992987249 @default.
- W2156792116 cites W1994472849 @default.
- W2156792116 cites W1999992455 @default.
- W2156792116 cites W2006980380 @default.
- W2156792116 cites W2012793999 @default.
- W2156792116 cites W2013043292 @default.
- W2156792116 cites W2037466942 @default.
- W2156792116 cites W2056330259 @default.
- W2156792116 cites W2057389492 @default.
- W2156792116 cites W2071499523 @default.
- W2156792116 cites W2080584760 @default.
- W2156792116 cites W2090489710 @default.
- W2156792116 cites W2098507056 @default.
- W2156792116 cites W2104191600 @default.
- W2156792116 cites W2113744970 @default.
- W2156792116 cites W2114158362 @default.
- W2156792116 cites W2116630833 @default.
- W2156792116 cites W2118420662 @default.
- W2156792116 cites W2119400958 @default.
- W2156792116 cites W2132609988 @default.
- W2156792116 cites W2134941291 @default.
- W2156792116 cites W2135037409 @default.
- W2156792116 cites W2135508758 @default.
- W2156792116 cites W2142636897 @default.
- W2156792116 cites W2143873194 @default.
- W2156792116 cites W2147406619 @default.
- W2156792116 cites W2153631681 @default.
- W2156792116 cites W2154525396 @default.
- W2156792116 cites W2158176003 @default.
- W2156792116 cites W2165267755 @default.
- W2156792116 cites W2170814847 @default.
- W2156792116 cites W2171861423 @default.
- W2156792116 cites W2259986462 @default.
- W2156792116 doi "https://doi.org/10.1073/pnas.0803195105" @default.
- W2156792116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2533223" @default.
- W2156792116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18725625" @default.
- W2156792116 hasPublicationYear "2008" @default.
- W2156792116 type Work @default.
- W2156792116 sameAs 2156792116 @default.
- W2156792116 citedByCount "197" @default.
- W2156792116 countsByYear W21567921162012 @default.
- W2156792116 countsByYear W21567921162013 @default.
- W2156792116 countsByYear W21567921162014 @default.
- W2156792116 countsByYear W21567921162015 @default.
- W2156792116 countsByYear W21567921162016 @default.
- W2156792116 countsByYear W21567921162017 @default.
- W2156792116 countsByYear W21567921162018 @default.
- W2156792116 countsByYear W21567921162019 @default.
- W2156792116 countsByYear W21567921162020 @default.
- W2156792116 countsByYear W21567921162021 @default.
- W2156792116 countsByYear W21567921162022 @default.
- W2156792116 countsByYear W21567921162023 @default.
- W2156792116 crossrefType "journal-article" @default.
- W2156792116 hasAuthorship W2156792116A5009197907 @default.
- W2156792116 hasAuthorship W2156792116A5027177608 @default.
- W2156792116 hasAuthorship W2156792116A5073005007 @default.
- W2156792116 hasAuthorship W2156792116A5078747529 @default.
- W2156792116 hasBestOaLocation W21567921161 @default.
- W2156792116 hasConcept C137610392 @default.
- W2156792116 hasConcept C147483822 @default.
- W2156792116 hasConcept C185592680 @default.
- W2156792116 hasConcept C195616568 @default.
- W2156792116 hasConcept C203014093 @default.
- W2156792116 hasConcept C2776789287 @default.
- W2156792116 hasConcept C2779281246 @default.
- W2156792116 hasConcept C501593827 @default.
- W2156792116 hasConcept C55493867 @default.
- W2156792116 hasConcept C86803240 @default.
- W2156792116 hasConcept C89423630 @default.
- W2156792116 hasConceptScore W2156792116C137610392 @default.
- W2156792116 hasConceptScore W2156792116C147483822 @default.
- W2156792116 hasConceptScore W2156792116C185592680 @default.
- W2156792116 hasConceptScore W2156792116C195616568 @default.
- W2156792116 hasConceptScore W2156792116C203014093 @default.
- W2156792116 hasConceptScore W2156792116C2776789287 @default.
- W2156792116 hasConceptScore W2156792116C2779281246 @default.
- W2156792116 hasConceptScore W2156792116C501593827 @default.
- W2156792116 hasConceptScore W2156792116C55493867 @default.
- W2156792116 hasConceptScore W2156792116C86803240 @default.
- W2156792116 hasConceptScore W2156792116C89423630 @default.
- W2156792116 hasIssue "36" @default.