FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156805105> ?p ?o ?g. }

• W2156805105 endingPage "1156" @default.
• W2156805105 startingPage "1140" @default.
• W2156805105 abstract "Sepsis and acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are associated with high mortality rates despite recent therapeutic advances. Both disease states involve uncontrolled host defense responses that lead to inflammation, endothelial damage, enhanced coagulation, diminished fibrinolysis and fibroproliferation to produce microthrombi, and relative adrenal insufficiency. Corticosteroids inhibit the host defense response and may offer an inexpensive therapeutic option. Results of several randomized, double-blind studies demonstrated no survival benefit and higher secondary infection rates when supraphysiologic doses of corticosteroids were administered for less than 24 hours. Recently, the emphasis of research for corticosteroid therapy has involved adrenocortical replacement dosage regimens administered for several days to weeks, with doses corresponding to the stress level of the disease. Stress-dose therapy with hydrocortisone in patients with septic shock who require vasopressor support, especially if adrenal insufficiency is present, accelerates hemodynamic stability and reduces mortality. The frequency of gastrointestinal hemorrhage was higher with corticosteroid therapy than with placebo, but the occurrence of secondary infections was similar to that of placebo. The only randomized, double-blind study that evaluated stress-dose methylprednisolone therapy for ARDS was terminated early after only 24 patients were enrolled because therapy with methylprednisolone was associated with enhanced survival despite higher secondary infection rates. A multicenter study investigating stress-dose methylprednisolone for ARDS is under way and should provide valuable information. Sufficient data support stress-dose hydrocortisone therapy for vasopressor-dependent septic shock. Stress-dose methylprednisolone therapy for ALI-ARDS requires further study but may be warranted in cases of refractory infection-induced ARDS when impending mortality is likely." @default.
• W2156805105 created "2016-06-24" @default.
• W2156805105 creator A5032609283 @default.
• W2156805105 creator A5040757935 @default.
• W2156805105 date "2002-09-01" @default.
• W2156805105 modified "2023-10-17" @default.
• W2156805105 title "Stress-Dose Corticosteroid Therapy for Sepsis and Acute Lung Injury or Acute Respiratory Distress Syndrome in Critically Ill Adults" @default.
• W2156805105 cites W1514001940 @default.
• W2156805105 cites W1522773084 @default.
• W2156805105 cites W1553380369 @default.
• W2156805105 cites W1586640515 @default.
• W2156805105 cites W1600551951 @default.
• W2156805105 cites W1717444875 @default.
• W2156805105 cites W1966077517 @default.
• W2156805105 cites W1966311800 @default.
• W2156805105 cites W1972754399 @default.
• W2156805105 cites W1974035400 @default.
• W2156805105 cites W1975143605 @default.
• W2156805105 cites W1981130762 @default.
• W2156805105 cites W1982552653 @default.
• W2156805105 cites W1984592139 @default.
• W2156805105 cites W1988243363 @default.
• W2156805105 cites W1989224759 @default.
• W2156805105 cites W1991555946 @default.
• W2156805105 cites W1992311120 @default.
• W2156805105 cites W1992334957 @default.
• W2156805105 cites W1992338015 @default.
• W2156805105 cites W1992456193 @default.
• W2156805105 cites W1992919388 @default.
• W2156805105 cites W1993810303 @default.
• W2156805105 cites W1994563911 @default.
• W2156805105 cites W1996620001 @default.
• W2156805105 cites W1999319544 @default.
• W2156805105 cites W2000684094 @default.
• W2156805105 cites W2001102650 @default.
• W2156805105 cites W2004061569 @default.
• W2156805105 cites W2011011061 @default.
• W2156805105 cites W2012023153 @default.
• W2156805105 cites W2012730520 @default.
• W2156805105 cites W2013539187 @default.
• W2156805105 cites W2017724041 @default.
• W2156805105 cites W2018103985 @default.
• W2156805105 cites W2018940949 @default.
• W2156805105 cites W2021783766 @default.
• W2156805105 cites W2022651477 @default.
• W2156805105 cites W2025101606 @default.
• W2156805105 cites W2025514580 @default.
• W2156805105 cites W2027977470 @default.
• W2156805105 cites W2030750548 @default.
• W2156805105 cites W2033621702 @default.
• W2156805105 cites W2037516773 @default.
• W2156805105 cites W2037533969 @default.
• W2156805105 cites W2038850118 @default.
• W2156805105 cites W2039229728 @default.
• W2156805105 cites W2042268246 @default.
• W2156805105 cites W2042676296 @default.
• W2156805105 cites W2043232914 @default.
• W2156805105 cites W2045898149 @default.
• W2156805105 cites W2046234889 @default.
• W2156805105 cites W2047406342 @default.
• W2156805105 cites W2049671131 @default.
• W2156805105 cites W2049927822 @default.
• W2156805105 cites W2050583714 @default.
• W2156805105 cites W2052092509 @default.
• W2156805105 cites W2052375478 @default.
• W2156805105 cites W2053980980 @default.
• W2156805105 cites W2056813798 @default.
• W2156805105 cites W2057288297 @default.
• W2156805105 cites W2059078435 @default.
• W2156805105 cites W2059176159 @default.
• W2156805105 cites W2061462402 @default.
• W2156805105 cites W2063233459 @default.
• W2156805105 cites W2065322500 @default.
• W2156805105 cites W2065755424 @default.
• W2156805105 cites W2066597122 @default.
• W2156805105 cites W2068392981 @default.
• W2156805105 cites W2069960650 @default.
• W2156805105 cites W2073276747 @default.
• W2156805105 cites W2075055228 @default.
• W2156805105 cites W2080245361 @default.
• W2156805105 cites W2083380272 @default.
• W2156805105 cites W2084683053 @default.
• W2156805105 cites W2086949509 @default.
• W2156805105 cites W2087241120 @default.
• W2156805105 cites W2087301662 @default.
• W2156805105 cites W2090676463 @default.
• W2156805105 cites W2093084020 @default.
• W2156805105 cites W2093799856 @default.
• W2156805105 cites W2099803817 @default.
• W2156805105 cites W2104968736 @default.
• W2156805105 cites W2112989757 @default.
• W2156805105 cites W2113643554 @default.
• W2156805105 cites W2114418858 @default.
• W2156805105 cites W2118442033 @default.
• W2156805105 cites W2120094753 @default.
• W2156805105 cites W2120854849 @default.
• W2156805105 cites W2124034004 @default.
• W2156805105 cites W2130279262 @default.

• next