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- W2156814170 abstract "The Ewing sarcoma protein (EWS) is a well-known player in cancer biology for the specific translocations occurring in sarcomas. The EWS-FLI1 gene fusion is the prototypical translocation that encodes the aberrant, chimeric transcription factor, which is a landmark of Ewing tumors. In all described Ewing sarcoma oncogenes, the EWS RNA binding domains are completely missing; thus RNA binding properties are not retained in the hybrid proteins. However, it is currently unknown whether the absence of EWS function in RNA metabolism plays a role in oncogenic transformation or if EWS plays a role by itself in cancer development besides its contribution to the translocation. In this regard, recent reports have highlighted an essential role for EWS in the regulation of DNA damage response (DDR), a process that counteracts genome stability and is often deregulated in cancer cells. The first part of this review will describe the structural features of EWS and its multiple roles in the regulation of gene expression, which are exerted by coordinating different steps in the synthesis and processing of pre-mRNAs. The second part will examine the role of EWS in the regulation of DDR- and cancer-related genes, with potential implications in cancer therapies. Finally, recent advances on the involvement of EWS in neuromuscular disorders will be discussed. Collectively, the information reviewed herein highlights the broad role of EWS in bridging different cellular processes and underlines the contribution of EWS to genome stability and proper cell-cycle progression in higher eukaryotic cells." @default.
- W2156814170 created "2016-06-24" @default.
- W2156814170 creator A5082875717 @default.
- W2156814170 date "2013-01-01" @default.
- W2156814170 modified "2023-09-23" @default.
- W2156814170 title "Ewing Sarcoma Protein: A Key Player in Human Cancer" @default.
- W2156814170 cites W115673842 @default.
- W2156814170 cites W1480741751 @default.
- W2156814170 cites W1492410820 @default.
- W2156814170 cites W1699609454 @default.
- W2156814170 cites W1965461792 @default.
- W2156814170 cites W1967554461 @default.
- W2156814170 cites W1969196565 @default.
- W2156814170 cites W1974293813 @default.
- W2156814170 cites W1976272896 @default.
- W2156814170 cites W1979877127 @default.
- W2156814170 cites W1981433220 @default.
- W2156814170 cites W1983409515 @default.
- W2156814170 cites W1984009890 @default.
- W2156814170 cites W1986596784 @default.
- W2156814170 cites W1987722299 @default.
- W2156814170 cites W2002435899 @default.
- W2156814170 cites W2002750338 @default.
- W2156814170 cites W2004850573 @default.
- W2156814170 cites W2005855776 @default.
- W2156814170 cites W2008510359 @default.
- W2156814170 cites W2010201645 @default.
- W2156814170 cites W2012116939 @default.
- W2156814170 cites W2018799668 @default.
- W2156814170 cites W2021466685 @default.
- W2156814170 cites W2023257749 @default.
- W2156814170 cites W2023566473 @default.
- W2156814170 cites W2024817377 @default.
- W2156814170 cites W2026726511 @default.
- W2156814170 cites W2036907121 @default.
- W2156814170 cites W2037502768 @default.
- W2156814170 cites W2040870350 @default.
- W2156814170 cites W2041757531 @default.
- W2156814170 cites W2042499074 @default.
- W2156814170 cites W2045402423 @default.
- W2156814170 cites W2047282635 @default.
- W2156814170 cites W2054077521 @default.
- W2156814170 cites W2056181171 @default.
- W2156814170 cites W2057034125 @default.
- W2156814170 cites W2059707627 @default.
- W2156814170 cites W2060123591 @default.
- W2156814170 cites W2063602321 @default.
- W2156814170 cites W2066280610 @default.
- W2156814170 cites W2067427176 @default.
- W2156814170 cites W2069351898 @default.
- W2156814170 cites W2071514329 @default.
- W2156814170 cites W2071837083 @default.
- W2156814170 cites W2072545392 @default.
- W2156814170 cites W2073204556 @default.
- W2156814170 cites W2074726646 @default.
- W2156814170 cites W2079321730 @default.
- W2156814170 cites W2080964315 @default.
- W2156814170 cites W2086824056 @default.
- W2156814170 cites W2088017477 @default.
- W2156814170 cites W2091002544 @default.
- W2156814170 cites W2092156970 @default.
- W2156814170 cites W2092648708 @default.
- W2156814170 cites W2105542427 @default.
- W2156814170 cites W2108191354 @default.
- W2156814170 cites W2111211899 @default.
- W2156814170 cites W2113124851 @default.
- W2156814170 cites W2117506397 @default.
- W2156814170 cites W2117936052 @default.
- W2156814170 cites W2118169789 @default.
- W2156814170 cites W2119060020 @default.
- W2156814170 cites W2119651404 @default.
- W2156814170 cites W2121488192 @default.
- W2156814170 cites W2122579813 @default.
- W2156814170 cites W2126812050 @default.
- W2156814170 cites W2126944841 @default.
- W2156814170 cites W2129602427 @default.
- W2156814170 cites W2135607950 @default.
- W2156814170 cites W2139326294 @default.
- W2156814170 cites W2139995230 @default.
- W2156814170 cites W2141231623 @default.
- W2156814170 cites W2146546145 @default.
- W2156814170 cites W2146642335 @default.
- W2156814170 cites W2148901907 @default.
- W2156814170 cites W2151371344 @default.
- W2156814170 cites W2151788284 @default.
- W2156814170 cites W2153553059 @default.
- W2156814170 cites W2157580663 @default.
- W2156814170 cites W2158263698 @default.
- W2156814170 cites W2159503940 @default.
- W2156814170 cites W2160299305 @default.
- W2156814170 cites W2162396524 @default.
- W2156814170 cites W2163731275 @default.
- W2156814170 cites W2168189152 @default.
- W2156814170 cites W2172466148 @default.
- W2156814170 cites W2313537120 @default.
- W2156814170 cites W2316715032 @default.
- W2156814170 cites W2325613032 @default.
- W2156814170 cites W4256069758 @default.